Abstract: Systems and methods for providing a wireless supplemental mouse interface for interacting with a wireless supplemental mouse are disclosed. The wireless supplemental mouse operates in addition to a primary mouse. In one aspect, the wireless supplemental mouse interface is physically integrated within a computer system such as a personal computer, server, or workstation. In another aspect, the wireless supplemental mouse interface is not physically integrated with a computer system, but instead is a remote interface that is coupled with a plurality of computer systems via a network. The remote wireless supplemental mouse interface receives signals from one or more wireless supplemental mice and determines which system to send the signals to for further processing.