Patents by Inventor Todd M. Greco

Todd M. Greco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sirtuin 4 (SIRT4) lipoamidase activity and uses thereof
    Patent number: 11726088
    Abstract: The present application provides a method of assaying pyruvate dehydrogenase complex (PDHC) activity in a mammalian cell that expresses human sirtuin 4 (SIRT4) comprising measuring a level of a dihydrolipoyllysine acetyltransferase (DLAT) lipoamide peptide comprising the amino acid sequence TDK[lipoyl]AT in the cell. The present application also demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 15, 2023
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas Shenk, Todd M. Greco, Ileana M. Cristea, Rommel A. Mathias, Adam Oberstein
  • SIRT4 Lipoamidase Activity and Uses Thereof
    Publication number: 20210318312
    Abstract: The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
    Type: Application
    Filed: August 12, 2020
    Publication date: October 14, 2021
    Inventors: Thomas Shenk, Todd M. Greco, Ileana M. Cristea, Rommel A. Mathias, Adam Oberstein
  • Method to increase the infectivity of virus particles
    Patent number: 11008551
    Abstract: A method for enhancing infectivity of HCMV virus particles is provided.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: May 18, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas Shenk, Nicole Gudleski O'Regan, Todd M. Greco, Ileana M. Cristea
  • SIRT4 lipoamidase activity and uses thereof
    Patent number: 10788492
    Abstract: The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: September 29, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas Shenk, Todd M. Greco, Ileana M. Cristea, Rommel A. Mathias, Adam Oberstein
  • SIRT4 LIPOAMIDASE ACTIVITY AND USES THEREOF
    Publication number: 20190094225
    Abstract: The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
    Type: Application
    Filed: January 15, 2015
    Publication date: March 28, 2019
    Inventors: Thomas Shenk, Todd M. Greco, IIeana M. Cristea, Rommel A. Mathias, Adam Oberstein
  • Method to increase the infectivity of virus particles
    Patent number: 10174290
    Abstract: A method for enhancing infectivity of HCMV virus particles is provided.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: January 8, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas Shenk, Nicole Gudleski O'Regan, Todd M. Greco, Ileana M. Cristea
  • Method to Increase the Infectivity of Virus Particles
    Publication number: 20180346885
    Abstract: A method for enhancing infectivity of HCMV virus particles is provided.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Inventors: Thomas Shenk, Nicole Gudleski O'Regan, Todd M. Greco, Ileana M. Cristea
  • METHOD TO INCREASE THE INFECTIVITY OF VIRUS PARTICLES
    Publication number: 20140212950
    Abstract: A method for enhancing infectivity of HCMV virus particles is provided.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 31, 2014
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas Shenk, Nicole Gudleski, Todd M. Greco