Abstract: A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . that is helpful for example with testing new drugs. A method for manufacturing the closed flow-through microplate is also described herein.

Abstract: A fluid handling system for transferring fluids is disclosed. The fluid handling system incorporates a plurality of transfer units for dispensing and/or collecting fluids as part of a closed analytical system. The plurality of transfer units are capable of functioning independently and/or collectively when assembled in a unitary array format. Methods of making and using the fluid handling system are also disclosed. The fluid handling system allows a sub-array of transfer units to shift in a vertical direction independent from a position of another sub-array of transfer units that are assembled within the same fluid head. Therefore, the fluid handling system facilitates multi-port fluid delivery and collection in an array format. Further, the fluid handling system aligned with a sensing surface enables label-free detection assays to be performed in an analytical system.

Abstract: A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . . that is helpful for example with testing new drugs. A method for manufacturing the closed flow-through microplate is also described herein.