Abstract: The present invention is a device and method for assuring “chain of custody” (CoC) in connection with a home sleep study (HST). An HST CoC device according to the invention includes a camera and a circuit board operatively connected to the camera. During the HST the circuit board signals the camera to periodically take images of the patient, to optimally assure CoC. The images are preferably still shots, but can alternatively be relatively short video clips. Further, the images are preferably taken randomly to discourage the patient from attempting to game the system and defeat CoC safeguards. Another embodiment includes a shipping container for a HST device, wherein a CoC device is operatively connected to the shipping container, whereby the CoC device is automatically returned to the lab along with the HST device following the HST.