Abstract: This disclosure provides multimeric binding molecules that specifically and agonistically bind to programmed cell death protein 1 (PD-1). This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating autoimmune disorders and preventing transplantation rejection.

Abstract: A rescue tool is for use with emergency extrications from a structure. The tool includes a shaft and a pair of arms coupled to the shaft. The shaft has an axis of symmetry, and the pair of opposing arms include a first arm and a second arm. At least one of the first arm and the second arm is slidably coupled to the shaft and is configured to move along the shaft in a direction that is substantially parallel to the shaft axis of symmetry. Each of the arms includes an inner face and an outer face. At least one of the arm inner and outer faces includes a plurality of teeth configured to contact the structure. At least one of the first arm and the second arm extends substantially perpendicularly to the shaft.

Abstract: A rescue tool is for use with emergency extrications from a structure. The tool includes a shaft and a pair of arms coupled to the shaft. The shaft has an axis of symmetry, and the pair of opposing arms include a first arm and a second arm. At least one of the first arm and the second arm is slidably coupled to the shaft and is configured to move along the shaft in a direction that is substantially parallel to the shaft axis of symmetry. Each of the arms includes an inner face and an outer face. At least one of the arm inner and outer faces includes a plurality of teeth configured to contact the structure. At least one of the first arm and the second arm extends substantially perpendicularly to the shaft.