Patents by Inventor Todd Milne

Todd Milne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of CRTH2 activity
    Patent number: 7205329
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: April 17, 2007
    Assignee: Microbia, Inc.
    Inventors: Yueh-Tyng Chien, G. Todd Milne, Mark G. Currie, John Jeffrey Talley, Brian M. Cali, Barbara Chen, Craig Zimmerman, Jing Jing Yang
  • love variant regulator molecules
    Patent number: 7196189
    Abstract: The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: March 27, 2007
    Assignee: Microbia, Inc.
    Inventors: Shannon Roberts, Amir Sherman, Joshua Trueheart, G. Todd Milne, John C. Royer
  • lovE variant regulator molecules
    Patent number: 7026460
    Abstract: The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: April 11, 2006
    Assignee: Microbia, Inc.
    Inventors: Shannon Roberts, Amir Sherman, Joshua Trueheart, G. Todd Milne
  • Methods for improving secondary metabolite production in fungi
    Patent number: 6949356
    Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: September 27, 2005
    Assignee: Microbia, Inc.
    Inventors: Robert Busby, Brian Cali, Peter Hecht, Doug Holtzman, Kevin Madden, Mary Maxon, Todd Milne, Thea Norman, John Royer, Sofie Salama, Amir Sherman, Jeff Silva, Eric Summers
  • Isolated nucleic acid molecule encoding a regulator of fungal gene expression
    Patent number: 6806082
    Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
    Type: Grant
    Filed: December 22, 2001
    Date of Patent: October 19, 2004
    Assignee: Microbia, Inc.
    Inventors: Brian M. Cali, Douglas Holtzman, Kevin T. Madden, G. Todd Milne, Amir Sherman, Jeffrey C. Silva, Joshua Trueheart, Lixin Zhang
  • lovE variant regulator molecules
    Publication number: 20040191877
    Abstract: The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
    Type: Application
    Filed: March 28, 2003
    Publication date: September 30, 2004
    Inventors: Shannon Roberts, Amir Sherman, Joshua Trueheart, G. Todd Milne, John C. Royer
  • Use of sublethal concentrations of anti-invasin compounds to therapeutically or prophylactically treat fungal infections
    Publication number: 20030176367
    Abstract: The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.
    Type: Application
    Filed: October 21, 2002
    Publication date: September 18, 2003
    Applicant: Microbia, Inc. a Delaware Corportion
    Inventors: Brian Cali, Etchell Cordero, Peter Hecht, G. Todd Milne, Sofie Salama, Eric Summers, Joshua Trueheart
  • IovE variant regulator molecules
    Publication number: 20030143705
    Abstract: The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
    Type: Application
    Filed: October 9, 2001
    Publication date: July 31, 2003
    Inventors: Shannon Roberts, Amir Sherman, Joshua Trueheart, G. Todd Milne
  • Cross-species bioactive peptides
    Publication number: 20030134329
    Abstract: The invention relates to the modulation of fungal signaling pathways. More particularly, the invention relates to compounds that modulate such pathways and to methods for identifying such compounds. The invention provides novel modulators of fungal gene expression that can be used to regulate or modulate activities of specific signaling pathways and to identify and validate potential targets in drug discovery efforts.
    Type: Application
    Filed: October 9, 2002
    Publication date: July 17, 2003
    Inventors: Thea Norman, Sofie R. Salama, Joshua Trueheart, G. Todd Milne, Peter Hecht
  • Novel regulators of fungal gene expression
    Publication number: 20020182708
    Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
    Type: Application
    Filed: December 22, 2001
    Publication date: December 5, 2002
    Inventors: Brian M. Cali, Douglas Holtzman, Kevin T. Madden, G. Todd Milne, Amir Sherman, Jeffrey C. Silva, Joshua Trueheart, Lixin Zhang
  • Methods for improving secondary metabolite production in fungi
    Publication number: 20020128250
    Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 12, 2002
    Inventors: Robert Busby, Brian Cali, Peter Hecht, Doug Holtzman, Kevin Madden, Mary Maxon, Todd Milne, Thea Norman, John Royer, Sofie Salama, Amir Sherman, Jeff Silva, Eric Summers
  • Method for efficient and highly selective control of microorganisms
    Patent number: 6440409
    Abstract: The invention features a method of selectively killing a first microorganism. The method includes: (i) contacting the first microorganism with a second microorganism that has a microcidal compound; and (ii) allowing the first microorganism and the second microorganism to undergo fusion, whereby the microcidal compound is delivered into and kills the microorganism that forms following the fusion.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: August 27, 2002
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: G. Todd Milne, Gerald R. Fink