Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the device.

Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.

Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the probe.

Abstract: Ultrasound mediated delivery (USMD), real-time quantitative feedback derived (S264) therefrom, and proceeding by the system based on the feedback all are, in some embodiments, operable automatically and without need for user intervention. USMD may occur in a clinical setting accompanied by assays (S276) or real-time feedback, or by means of a wearable device that, based on feedback, regulates USMD in real time. Optionally, the user is provided an indication (S281) as to progress or success, of a treatment. Electrodes (128) may be attached across tissue in which transient pores are produced via sonoporation in the USMD procedure, and in vivo measurement is taken of an electrical parameter responsive to permeability. Therapeutic agent (S202) may be administered after particles activated for sonoporation are cleared from the circulation, to avoid, when it might exist, adverse interaction between the particles and agent.

Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.