Abstract: Methods for making semiconductor devices are disclosed herein. A method configured in accordance with a particular embodiment includes forming a spacer material on an encapsulant such that the encapsulant separates the spacer material from an active surface of a semiconductor device and at least one interconnect projecting away from the active surface. The method further includes molding the encapsulant such that at least a portion of the interconnect extends through the encapsulant and into the spacer material. The interconnect can include a contact surface that is substantially co-planar with the active surface of the semiconductor device for providing an electrical connection with the semiconductor device.

Abstract: An apparatus includes a plurality of front-end nonlinear optical crystals and a plurality of back-end nonlinear optical crystals. The front-end nonlinear optical crystals are arranged in a chain and are configured to amplify a received signal. The back-end nonlinear optical crystals are arranged in the chain after the front-end nonlinear optical crystals and are configured to further amplify the received signal and generate an amplified signal. The back-end nonlinear optical crystals are made from a different nonlinear optical crystal than the front-end nonlinear optical crystals.

Abstract: A catheter system for atraumatic placement along a guidewire includes: a catheter including a cylindrical catheter body that defines a longitudinally extending interior lumen; and a guide device. The guide device includes: a conduit member for insertion into the interior lumen of the catheter body; a leading structure connected to a forward end of the conduit member, the leading structure including a cone and a sleeve extending forward from the cone; and an inner guide hole extending longitudinally through the leading structure and conduit member. In use, the guide device and catheter body are coaxially arranged, the cone is forward of the catheter, and the sleeve extends forward from the cone. The cone includes a shoulder, and a tapered exterior that increases diametrically from the sleeve to the shoulder. The shoulder abuts a distal end of the catheter to register insertion of the guide device in the catheter.

Abstract: The present invention provides for a protein cage polypeptide (or scaffolding protein) useful or capable of forming a hollow tetrahedral pyramid structure, and a “self-assembling protein nanoparticle decorated with antibodies” (SAPNA) which is a chimeric protein assembly comprising: (a) one or more antibodies and (b) the protein cage polypeptide that provides a scaffold upon which to array the antibodies. In some embodiments, the antibody is capable of binding specifically to a pathogenic biological agent, or part thereof.

Abstract: A multilayer film for use in adhesive tape or adhesive label applications comprising a core layer and skin layers on each side of the core layer. The core layer comprises a polypropylene mini-random homopolymer, wherein the mini-random homopolymer comprises polypropylene, up to 2 wt % ethylene components, and a acid neutralizer in a concentration up to 5000 ppm calcium. The skin layers each comprise a) at least about 95 wt % of a polypropylene mini-random homopolymer comprising polypropylene, up to 2 wt % ethylene components, and an acid neutralizer in a concentration up to about 5000 ppm, and b) an anti-block agent in a concentration up to about 1 wt %, wherein the anti-block agent comprises at least 95 wt % homopolymer of polypropylene and 1 to 5 wt % of silica having a particle size between about 1 to 3 ?m.

Abstract: Systems, Methods and Devices to apply concomitant cold and vibratory stimulus immediately prior to injection to reduce pain, in a simple and mechanically advantaged device actuatable by a user's non-dominant hand or a third party.

Abstract: A multilayer film for use in adhesive tape or adhesive label applications comprising a core layer and skin layers on each side of the core layer. The core layer comprises a polypropylene mini-random homopolymer, wherein the mini-random homopolymer comprises polypropylene, up to 2 wt % ethylene components, and a acid neutralizer in a concentration up to 5000 ppm calcium. The skin layers each comprise a) at least about 95 wt % of a polypropylene mini-random homopolymer comprising polypropylene, up to 2 wt % ethylene components, and an acid neutralizer in a concentration up to about 5000 ppm, and b) an anti-block agent in a concentration up to about 1 wt %, wherein the anti-block agent comprises at least 95 wt % homopolymer of polypropylene and 1 to 5 wt % of silica having a particle size between about 1 to 3 ?m.

Abstract: Example embodiments are described that relate to the analysis of tissue damage in an injured patient. Example embodiments are methods and systems for collecting medical imaging data, identifying tissue damage in the medical imaging data, analyzing the tissue damage shown in the medical imaging data, and/or quantifying the tissue damage shown in the medical imaging data. The disclosed methods allow for determining a risk for multiple organ failure and systemic inflammation in a multiply injured patient.

Abstract: Provided is a process that includes: obtaining, with an artificial intelligence (AI) application executed by a computer system, information about a current patient condition related to heart failure; inputting, with the computer system, at least some of the obtained information about the patient condition into respective pharmaceutical-specific models to obtain candidate classes of pharmaceuticals and their respective priority scores; inputting, with the computer system, into an expert system of the AI application, the candidate classes of pharmaceuticals and their respective priority scores and, in response, determining an updated prescription.

Abstract: A customizable router manages traffic between application programming interfaces (APIs) of microservice applications (apps) that make up various features of a website. Various datastores may also be used to store information, such as information related to certain products, pricing, users, etc. In order for the website to function properly, the microservice apps communicate with one another and with the datastores. The customizable router is used to manage and route traffic between the microservice apps and/or datastores. The customizable router may, for example, route a universal resource indicator (URI) request for a webpage of a website to particular versions or revisions of a microservice app based on rules established for the customizable router. For example, a certain percentage of traffic may be routed to a first version of a microservice app, while a different percentage of traffic may be routed to a second version of the microservice app.

Abstract: Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.

Abstract: A customizable router manages traffic between application programming interfaces (APIs) of microservice applications (apps) that make up various features of a website. Various datastores may also be used to store information, such as information related to certain products, pricing, users, etc. In order for the website to function properly, the microservice apps communicate with one another and with the datastores. The customizable router is used to manage and route traffic between the microservice apps and/or datastores. The customizable router may, for example, route a universal resource indicator (URI) request for a webpage of a website to particular versions or revisions of a microservice app based on rules established for the customizable router. For example, a certain percentage of traffic may be routed to a first version of a microservice app, while a different percentage of traffic may be routed to a second version of the microservice app.

Abstract: Provided is a process, including: obtaining test data that quantifies a patient's cardiovascular status, the test data specifying patient attributes in a plurality of cardiovascular dimensions of the patient; determining a plurality of normalized differences between the test data and target criteria in each of the cardiovascular dimensions; determining predicted-effect vectors of each of a plurality of different classes of pharmaceuticals; determining an aggregate score for each respective class of pharmaceuticals among the different classes of pharmaceuticals based on values of the corresponding predicted-effect vectors; ranking the different classes of pharmaceuticals based on the aggregate scores; and outputting a recommended sequence of pharmaceuticals to administer.

Abstract: This disclosure relates to methods of treating cancer (e.g., melanoma) with (MI-181).

Abstract: Spectral beam combining systems including a multi-element transform optic. In certain examples the multi-element transform optic includes a first cylindrical optical element having positive optical power in a first axis, a second optical element having negative optical power in the first axis, and a third toroidal optical element having positive optical power in the first axis and either positive or negative optical power in a second axis that is orthogonal to the first axis. The first and third optical elements are positioned on opposite sides of the second optical element and equidistant from the second optical element. The multi-element transform optic has an optical path length extending between a front focal plane and a back focal plane that is shorter than an effective focal length of the multi-element transform optic.

Abstract: Apparatus and methods are described herein for multiple single level security (MSLS) domains including, but not limited to, a secure kernel hypervisor (SKH). The SKH configures a single multi-tenant cloud to host the MSLS domains. A cloud orchestration system (COS) configures the single multi-tenant cloud to set up a plurality of separate virtual work packages (VWPs) for the MSLS domains. A key management system (KMS) is configured to manage security objects associated with the MSLS domains.

Abstract: A customizable router manages traffic between application programming interfaces (APIs) of microservice applications (apps) that make up various features of a website. Various datastores may also be used to store information, such as information related to certain products, pricing, users, etc. In order for the website to function properly, the microservice apps communicate with one another and with the datastores. The customizable router is used to manage and route traffic between the microservice apps and/or datastores. The customizable router may, for example, route a universal resource indicator (URI) request for a webpage of a website to particular versions or revisions of a microservice app based on rules established for the customizable router. For example, a certain percentage of traffic may be routed to a first version of a microservice app, while a different percentage of traffic may be routed to a second version of the microservice app.

Abstract: A molded article formed from a polymer composition, the polymer composition consisting essentially of: an ethylene homopolymer or ethylene/alpha-olefin copolymer; greater than 20 ppm of a fluoropolymer; and optionally, up to 5 wt. % of one or more of processing aids, acid neutralizers, stabilizers, phosphites, antioxidants, metal de-activators, pigments or colorants, or fillers; wherein the molded article exhibits an oxygen transmission rate [OTR, (cc*mm)/(m2*day*atm)]??3181 (cc2*mm)/g*m2*day*atm)×[Density, g/cc]+3077, (cc*mm)/(m2*day*atm).

Abstract: Methods for making semiconductor devices are disclosed herein. A method configured in accordance with a particular embodiment includes forming a spacer material on an encapsulant such that the encapsulant separates the spacer material from an active surface of a semiconductor device and at least one interconnect projecting away from the active surface. The method further includes molding the encapsulant such that at least a portion of the interconnect extends through the encapsulant and into the spacer material. The interconnect can include a contact surface that is substantially co-planar with the active surface of the semiconductor device for providing an electrical connection with the semiconductor device.

Abstract: Apparatus and methods are described herein for multiple single level security (MSLS) domains including, but not limited to, a secure kernel hypervisor (SKH). The SKH configures a single multi-tenant cloud to host the MSLS domains. A cloud orchestration system (COS) configures the single multi-tenant cloud to set up a plurality of separate virtual work packages (VWPs) for the MSLS domains. A key management system (KMS) is configured to manage security objects associated with the MSLS domains.