Abstract: Syringes are provided that include a syringe body defining a syringe cavity, a syringe port, and an indicator window, a medication plunger disposed within the syringe cavity and defining a medication chamber in the syringe cavity, a priming indicator comprising a first indicator portion and a second indicator portion, the priming indicator coupled to a plunger shaft of the medication plunger, wherein the priming indicator presents the first indicator portion through the indicator window in an unprimed position and presents the second indicator portion through the indicator window in a primed position, and a saline plunger disposed on the plunger shaft, the saline plunger disposed within the syringe cavity and defining a saline chamber in the syringe cavity. Medication delivery systems and methods to deliver medication via medication delivery systems are also provided.

Abstract: Various intraoral gastrointestinal access devices, systems, and methods are disclosed herein to deliver substance directly to a target gastrointestinal tract site of a user while bypassing other portions of the gastrointestinal tract. The intraoral gastrointestinal access devices can be anchored within a mouth of a user and are generally concealed when not in use. The intraoral gastrointestinal access devices can include a port that is docked in the mouth when not in use and positioned outside the mouth to receive substance from a delivery device with a reservoir of the substance.

Abstract: A medical connector may include a body having an outer surface and an inner surface defining a lumen of the body, an inlet port defined at a proximal end of the body, and an outlet port defined at a distal end of the body. The medical connector may further include a compressible valve member comprising a normally closed slit and disposed in the lumen and extending through the inner surface and outer surface of the body to an exterior of the medical connector. The compressible valve member may be configured to compress radially inward to open the slit upon insertion of the body into a medical access device, and expand radially outward to close the slit upon disconnection of the body from the medical access device.

Abstract: Syringes are described herein. A syringe includes a syringe body, a first plunger, a biasing member, and a priming indicator. The syringe body defines a syringe cavity, a syringe port, and an indicator window, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger comprises a first plunger shaft extending from the first plunger, the first plunger disposed within the syringe cavity and defining a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The biasing member couples to the first plunger shaft, wherein the biasing member urges the first plunger from an unprimed position to a primed position toward the syringe port. The priming indicator presents the first indicator portion through the indicator window in the unprimed position and presents the second indicator portion through the indicator window in the primed position.

Abstract: Valves and medication delivery systems including valves are described herein. A valve includes a valve body and a valve element. The valve body defines a first flow path, a second flow path, and a catheter flow path. The valve element is disposed within the valve body, wherein the valve element is configured to permit fluid communication between the first flow path and the second flow path in a priming position, and is configured to permit fluid communication between the first flow path and the catheter flow path in a dispensing position.

Abstract: An archform configured to move a patient's teeth using non-sliding mechanics. The archform can include a loop between two bracket connectors that spans a blocked-out tooth between two teeth. One or more of the bracket connectors can include a reinforced shoulder to provides increased structural integrity to the connection between the bracket connector and the loop. The archform can include a second loop between the two connectors that is gingivally or occlusally positioned relative to other loop.

Abstract: Syringe control assemblies are described herein. A syringe control assembly includes an assembly body, a first syringe, a second syringe, and a pump assembly. The first and second syringes are releasably coupled to a syringe mounting rack of the assembly body. The pump assembly includes a first pump unit and a second pump unit. Each pump unit is in fluid communication with each respective syringe. In a priming configuration, the first pump unit is configured to draw fluid flow from the first syringe cavity and the second pump unit is configured to pump fluid flow into the second syringe cavity.

Abstract: Various intraoral gastrointestinal access devices, systems, and methods are disclosed herein to deliver substance directly to a target gastrointestinal tract site of a user while bypassing other portions of the gastrointestinal tract. The intraoral gastrointestinal access devices can be anchored within a mouth of a user and are generally concealed when not in use. The intraoral gastrointestinal access devices can include a port that is docked in the mouth when not in use and positioned outside the mouth to receive substance from a delivery device with a reservoir of the substance.

Abstract: Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a dry disconnect shuttle valve comprising a male portion and a female portion, the dry disconnect shuttle valve configured for needleless use and maintaining a leak-free seal at disconnection with the at least one diluent port comprising the female portion of the dry disconnect shuttle valve.

Abstract: Syringe control assemblies are described herein. A syringe control assembly includes an assembly body, a first syringe, a second syringe, and a pump assembly. The first and second syringes are releasably coupled to a syringe mounting rack of the assembly body. The pump assembly includes a first pump unit and a second pump unit. Each pump unit is in fluid communication with each respective syringe. In a priming configuration, the first pump unit is configured to draw fluid flow from the first syringe cavity and the second pump unit is configured to pump fluid flow into the second syringe cavity.

Abstract: A syringe includes a syringe body, a first plunger, a second plunger, and an inner tube. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger is disposed within the syringe cavity and defines a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The second plunger is disposed within the syringe cavity, the first plunger and the second plunger cooperatively defining a second chamber in the syringe cavity. The inner tube comprises an inner tube lumen, wherein the inner tube and the first plunger shaft lumen of a first plunger shaft define an annulus therebetween, the annulus in fluid communication with a first plunger channel of the first plunger and the annulus permits fluid communication between the syringe port and the first plunger channel.

Abstract: Syringes are described herein. A syringe includes a syringe body, a first plunger, a biasing member, and a retention member. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger comprises a first plunger shaft extending from the first plunger, the first plunger disposed within the syringe cavity and defining a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The biasing member is coupled to the first plunger shaft, wherein the biasing member urges the first plunger to advance toward the syringe port. The retention mechanism prevents the biasing member from advancing the first plunger in an engaged position and permits the biasing member to advance the first plunger in a released position.

Abstract: Methods of directly bonding a non-sliding archform to a patient's teeth are disclosed herein. An IDB tray with wells sized and shaped to form orthodontic brackets can be filled with a fluid, such as an adhesive or bonding agent. The IDB tray with the fluid-filled wells can be placed over the teeth of the patient. The fluid in the wells can contact the surfaces of the teeth. The fluid can be cured by way of exposure to UV light, forming orthodontic brackets and bonding the orthodontic brackets to the patient's teeth.

Abstract: A syringe includes a syringe body, a first plunger, a second plunger, and an inner tube. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger is disposed within the syringe cavity and defines a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The second plunger is disposed within the syringe cavity, the first plunger and the second plunger cooperatively defining a second chamber in the syringe cavity. The inner tube comprises an inner tube lumen, wherein the inner tube and a first plunger shaft lumen of a first plunger shaft define an annulus therebetween, the annulus in fluid communication with a first plunger channel of the first plunger and the annulus permits fluid communication between the syringe port and the first plunger channel.

Abstract: An indirect orthodontic bonding (IDB) tray preloaded with one or more orthodontic brackets with uncured pre-pasted adhesive. The loaded IDB tray can be produced by an IDB tray manufacturer and distributed to an orthodontist in a container that prevents the adhesive from curing. The loaded IDB tray can be removed from the container when the patient is ready for treatment. The loaded IDB tray can be placed over the dental arch of the patient such that the one or more orthodontic brackets can bond, via curing of the adhesive, to the teeth of the patient.

Abstract: Syringe assemblies are described herein. A syringe assembly includes an assembly housing, a first syringe, a second syringe, and a connecting gear. The first syringe is disposed within the assembly housing. Each plunger is movable within the respective syringe cavity and defines a respective chamber in the respective syringe cavity, wherein the respective chamber is in fluid communication with the respective syringe port, the respective plunger comprising a respective gear rack extending longitudinally along the respective plunger. The connecting gear is rotatably coupled to the assembly housing. The connecting gear is configured to be in meshed engagement with at least one of the first gear rack and the second gear rack of the syringes.

Abstract: A needleless connector includes a housing having a central longitudinal axis, a body portion, and a base portion. The body portion includes an inner surface forming an internal cavity, and a first port forming a first fluid passage to the housing cavity. The base portion includes a top end section and a bottom end section. The top end section has a protrusion, and the bottom end portion has a second port forming a second fluid passage to the housing cavity. The needleless connector further includes a valve having a wall with an inner surface forming a valve cavity. The valve is coupled with the housing such that the protrusion is positioned in the valve cavity, and a proximal end of the protrusion is spaced apart from a proximal end of the valve cavity.

Abstract: Syringes are described herein. A syringe includes a syringe body, a first plunger, a biasing member, and a retention member. The syringe body defines a syringe cavity and a syringe port, wherein the syringe port is in fluid communication with the syringe cavity. The first plunger comprises a first plunger shaft extending from the first plunger, the first plunger disposed within the syringe cavity and defining a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The biasing member is coupled to the first plunger shaft, wherein the biasing member urges the first plunger to advance toward the syringe port. The retention mechanism prevents the biasing member from advancing the first plunger in an engaged position and permits the biasing member to advance the first plunger in a released position.

Abstract: An orthodontic bracket and archform system that uses friction-free mechanics are disclosed. The archform can have a male fastener that can be retained within an orthodontic bracket. The orthodontic bracket can have varying locking mechanism, such as deflectable tabs, springs, locking pins, and others, that can cooperate with features of the male fastener to prevent sliding between the archform and the bracket.