Patents by Inventor Todd P. Michael

Todd P. Michael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED NUCLEIC ACIDS FOR NANOPORE ANALYSIS
    Publication number: 20180164280
    Abstract: Provided herein is technology relating to nanopore analysis of nucleic acids and particularly, but not exclusively, to compositions, methods, systems, and kits for analysis of nucleic acids or other assays comprising nucleic acid components.
    Type: Application
    Filed: November 6, 2017
    Publication date: June 14, 2018
    Inventors: David J. Ecker, Stanley T. Motley, James C. Hannis, Lara G. Krieg, Todd P. Michael, David D. Duncan, Shane G. Poplawski, Thomas N. Chiesl
  • MALAT-1, A NON-CODING RNA, IS A TARGET FOR THE REGULATION OF LEARNING AND MEMORY
    Publication number: 20170335321
    Abstract: Provided herein are methods for improving memory or cognitive function in a subject by administering a composition to the brain of the subject, where the composition comprises: i) a compound that increases expression of MALAT-1 long non-coding RNA, ii) a MALAT-1 long-coding RNA nucleic acid sequence, or iii) at least one MALAT-1 derived piRNA nucleic acid sequence. Also provided herein are methods of screening candidate compounds for their ability to modulate the expression of MALAT-1 long non-coding RNA in brain cells. In certain embodiments, such identified modulators that increase expression are further administered to the brain of a lab animal to determine the impact of such modulators on learning and memory.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 23, 2017
    Inventors: Todd P. Michael, Stanley T. Motley
  • ALTERATION OF NEURONAL GENE EXPRESSION BY SYNTHETIC piRNAs AND BY ALTERATION OF piRNA FUNCTION
    Publication number: 20170275622
    Abstract: Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 28, 2017
    Inventors: David J. Ecker, Todd P. Michael, Lendell L. Cummins, Mark W. Eshoo, Stanley T. Motley, Danny M. Chou
  • Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function
    Patent number: 9605260
    Abstract: Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 28, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Todd P. Michael, Lendell L. Cummins, Mark W. Eshoo, Stanley T. Motley, Danny M. Chou
  • ALTERATION OF NEURONAL GENE EXPRESSION BY SYNTHETIC piRNAs AND BY ALTERATION OF piRNA FUNCTION
    Publication number: 20140275216
    Abstract: Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: IBIS Biosciences, Inc.
    Inventors: David J. Ecker, Todd P. Michael, Lendell L. Cummins, Mark W. Eshoo, Stanley T. Motley, Danny M. Chou
  • ZINC KNUCKLE PROTEINS
    Publication number: 20120017335
    Abstract: TZP proteins and method of their use for improving plant characteristics are disclosed.
    Type: Application
    Filed: October 9, 2009
    Publication date: January 19, 2012
    Applicant: The Salk Institute for Biological Studies
    Inventors: Olivier Loudet, Todd P. Michael, Detlef Weigel, Joanne Chory