Abstract: A handle for an oral-care implement for safe and hygienic use by multiple users includes an electrical motor and a detachable head. The handle has a display for displaying instructions to control functional operation of the handle, a microcontroller for controlling the motor and the display, and at least one switch to allow a user to control the functional operation of the handle, including causing the output element to vibrate in at least one oral-hygiene mode having an oral-hygiene frequency and causing the output element to vibrate in a disinfection mode when the handle is being disinfected before or after being used for the oral-hygiene routine. The disinfection mode has a modulated frequency, different from the oral-hygiene frequency, and alternating up and down between a low modulated frequency and a high modulated frequency, wherein the high modulated frequency is at least 50 percent greater than the low modulated frequency.

Abstract: Methods, apparatuses, devices, and optical components are described. One or more materials used in an optical system may be bonded together using a pulsed laser beam. The bonding process may include transmitting a pulsed laser to irradiate an interface between two components, which may include two optical components or an optical component and a mounting component. The pulsed laser may generate one or more bonding locations where the components are in relatively close contact with each other, which may secure the components together via at least partial melting of material at one or more surfaces of the components. In some examples, the pulsed laser may be scanned over the bonding locations some quantity of times and/or using a pattern to achieve the bond. In some aspects, one or more absorbing layers may be added to the components.

Abstract: Provided are systems and methods for managing a processing load of a processing module and thermal energy produced by the processing load. In one example, a method includes identifying a hot water profile that contains usage information of hot water from a hot water tank that serves as a heat sink for the thermal energy. A determination may be made as to whether it is economically desirable to increase or decrease the processing load based on factors such as an economic value generated by the processing load, a cost of energy needed to support the processing load, and an economic value of the thermal energy transferred to the hot water tank based on the hot water profile. The processing load may be dynamically modulated by a local or remote controller in response to the economic desirability of increasing or decreasing the processing load as well as other possible parameters.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A seabased resupply system includes a fuel containment structure containing fuel and extending fore and aft along a longitudinal axis, a pump on the fuel containment structure operable to pump the fuel, containers located on an exterior of opposite lateral sides of the fuel containment structure, and an operating system located inside one or more of the containers, the operating system comprising at least one selected from a power supply, a communication system, and a control processor.

Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: The disclosure relates to natural oil-based petrolatum compositions and a method of making the same. The natural oil-based petrolatum composition includes the esterification product of: about 0.1 wt % to about 35 wt % a fatty acid dimer, about 5 wt % to about 30 wt % a C8 to C22 fatty acid, and about 65 wt % to about 95 wt % hydrogenated natural oil, wherein the natural based petrolatum product has an acid value of less than 25. Natural oil-based petrolatum compositions can be used in personal care products.

Abstract: The disclosure relates to natural oil-based petrolatum compositions and a method of making the same. The natural oil-based petrolatum composition includes the esterification product of a pre-esterification mixture of: about 15 wt % to about 25 wt % a fatty acid dimer, about 15 wt % to about 25 wt % glycerin, and about 55 wt % to about 70 wt % hydrogenated natural oil, wherein the natural oil-based petrolatum product has an acid value of less than 5.0. Natural oil-based petrolatum compositions can be used in personal care products.

Abstract: The disclosure relates to natural oil-based petrolatum compositions and a method of making the same. The natural oil-based petrolatum composition includes the esterification product of: about 0.1 wt % to about 40 wt % a fatty acid dimer, about 99.9 wt % to about 60 wt % of one or more components selected from the group consisting of C1-C6 polyols, natural oils, fatty acids, and acyls glycerols, wherein the natural based petrolatum product has a cone penetration value of greater than 10 and a polydispersity index greater than 1.3. Natural oil-based petrolatum compositions can be used in personal care products.

Abstract: While a vehicle is in a minimal power state, a first sensor is activated based on a location of the vehicle within a monitored area. The vehicle is transitioned to an on state based on detecting an object via data from the first sensor. Then the vehicle is operated to block an exit from the monitored area based on identifying the object as an unauthorized object.

Abstract: Vehicle advanced driver-assistance system (ADAS) techniques include, during an ADAS event where a controller at least partially takes control of the vehicle from a driver, detecting, using at least a driver monitoring system, a driver attentiveness level and a control urgency level indicative of how important it is for the driver to potentially retake control of the vehicle, determining, based on the detected driver attentiveness level and the detected control urgency level, a desired driver alert level for attempting to regain the driver's attention for the driver to potentially retake control of the vehicle from a plurality of predetermined driver alert levels each including at least one of an audio/visual/haptic (AVH) alert and a degree of a braking event, and commanding, according to the desired driver alert level, at least one of an AVH alert system and an anti-lock braking system (ABS).

Abstract: A process for the oxidative coupling of methane to one or more C2+ hydrocarbons which includes subjecting a gas stream comprising methane, ethylene, optionally ethane and optionally nitrogen, resulting from subjecting methane and oxygen or air to methane oxidative coupling conditions, to two consecutive sorption steps which comprise contacting said gas stream comprising methane, ethylene, optionally ethane and optionally nitrogen with a selective sorption agent, resulting in sorption of part of said gas stream, comprising ethylene and optionally ethane, by the sorption agent and in a gas stream comprising the remainder of said gas stream, comprising methane, optionally ethane and optionally nitrogen, which latter gas stream is subjected to a second sorption step resulting in a further separation, finally resulting in a gas stream comprising methane, wherein each sorption step is followed by a desorption step which comprises desorbing the sorbed components originating from the gas stream in question.

Abstract: Processing of a reaction product mixture of cellulosic biomass material containing at least one volatile organic compound at least one of lignin, a lignin-derived compound, unextracted cellulose, unextracted hemicellulose, a caramelan, and any combination thereof by vaporizing the at least one volatile organic compound using at least thermal energy generated by combusting at least a portion of the reaction product mixture. In a particular embodiment, the reaction product mixture comes from reactions involving deconstruction (or digestion) of cellulosic biomass which contains various polysaccharides (e.g., carbohydrates) and lignin.

Abstract: A bottom fraction of a product of a hydrocatalytic reaction is gasified to generate hydrogen for use in further hydrocatalytic reactions. In one embodiment, one or more volatile organic compounds is also vaporized using heat generated in the gasification process. In one embodiment, an overhead fraction of the hydrocatalytic reaction is further processed to generate higher molecular weight compounds. In another embodiment, a product of the further processing is separated into a bottom fraction and an overhead fraction, where the bottom fraction is also gasified to generate hydrogen for use in further hydrocatalytic reactions.

Abstract: Systems and methods of end-to-end continuous integration and verification of software are described. A system comprises, for example, a provisioning service module configure to automatically retrieve source code from a source code management system. The provisioning service module further generates one or more environments. A propagation management module is configured to package the retrieved source code into a deliverable and to automatically propagate the deliverable through a pipeline comprising the one or more environments.

Abstract: Processing of a reaction product mixture of cellulosic biomass material containing at least one volatile organic compound at least one of lignin, a lignin-derived compound, unextracted cellulose, unextracted hemicellulose, a caramelan, and any combination thereof by vaporizing the at least one volatile organic compound using at least thermal energy generated by combusting at least a portion of the reaction product mixture. In a particular embodiment, the reaction product mixture comes from reactions involving deconstruction (or digestion) of cellulosic biomass which contains various polysaccharides (e.g., carbohydrates) and lignin.

Abstract: A bottom fraction of a product of a hydrocatalytic reaction is gasified to generate hydrogen for use in further hydrocatalytic reactions. In one embodiment, one or more volatile organic compounds is also vaporized using heat generated in the gasification process. In one embodiment, an overhead fraction of the hydrocatalytic reaction is further processed to generate higher molecular weight compounds. In another embodiment, a product of the further processing is separated into a bottom fraction and an overhead fraction, where the bottom fraction is also gasified to generate hydrogen for use in further hydrocatalytic reactions.

Abstract: Systems and methods of end-to-end continuous integration and verification of software are described. A system comprises, for example, a provisioning service module configure to automatically retrieve source code from a source code management system. The provisioning service module further generates one or more environments. A propagation management module is configured to package the retrieved source code into a deliverable and to automatically propagate the deliverable through a pipeline comprising the one or more environments.

Abstract: Aspects of the invention provide methods and architectures for enhancing the reliability of computer appliances and reducing the possibilities that human intervention is necessary in the event of a system failure or failure condition. The provided architecture is extensible and provides a generalized framework that is adaptable to many different types of computer appliances. One aspect of the invention provides a boot up redundancy component to ensure that a computer appliance can be appropriately booted. In the described embodiment the appliance hard drive is configured with multiple partitions that can be utilized to boot the appliance thereby reducing the chances that the appliance will not boot. In addition, an architecture is disclosed that comprises one or more resource monitoring components that monitor an associated appliance resource for a failure condition. The resource monitoring components are programmed to attempt to remedy certain failure conditions that they detect.