Abstract: The present technology provides an approach to designing libraries of peptide sequences for discovery and testing of significantly more motifs than would be otherwise available in a given fixed library format. The technology includes a plurality of x-mers embedded in N-mer peptides sequences, where N and x are integers and where N is greater than x. This approach provides for the representation of multiple unique x-mer peptides in a single N-mer peptide feature.

Abstract: An aspiration device to be used with an irrigation-aspiration handpiece may comprise a curved body having a radius of curvature based on a human equatorial lens diameter, an interface adapted to attach the curved body to a first end of an aspiration lumen in the irrigation-aspiration handpiece, and multiple aspiration ports formed in the curved body. The multiple aspiration ports may be adapted to draw material into the aspiration lumen when a suction source is used to apply vacuum pressure at a second of the aspiration lumen while the aspiration lumen is attached to the aspiration device. The multiple aspiration ports may be arranged to distribute the vacuum pressure over an aggregate surface area of the multiple aspiration ports while the suction source applies the vacuum pressure.

Abstract: The present invention is a door barricade having a pivoting locking arm which drops into a floor hole to lock a barricade in place.

Abstract: A surgical tool assembly is disclosed. The surgical tool assembly includes a forceps instrument including a proximal handle portion with an actuator, and a distal forceps portion including jaws. The actuator selectively moves the jaws. The surgical tool assembly includes an infusion assembly including a tube configured to be connected to a fluid source at a primary tube end and connected to a fitting at a paracentesis tube end. The fitting defines a passage configured to receive the distal forceps portion of the forceps instrument. An infusion sleeve extends away from the fitting. The infusion sleeve is arranged concentric around an outer surface of the distal forceps portion to define a fluid pathway. The jaws extend beyond a terminal end of the infusion sleeve such that the jaws are arranged outside of the infusion sleeve.

Abstract: The present invention is a door barricade having a pivoting locking arm which drops into a floor hole to lock a barricade in place.

Abstract: The present invention is a door barricade having a pivoting locking arm which drops into a floor hole to lock a barricade in place.

Abstract: A microsurgical instrument for illuminating an interior site includes an optical fiber having a length between opposed proximal and distal ends, wherein the proximal end of the optical fiber is configured for operative engagement with an illumination light source, the distal end of the optical fiber including a light emitting portion, a preformed curved portion of the optical fiber proximate to the distal end, wherein the curved portion has a predetermined bend or curve, a flexible tubular sleeve enclosing at least a portion of the optical fiber, wherein the tubular sleeve has a preformed curved portion corresponding to the curved portion of the optical fiber.

Abstract: The present invention is a door barricade having a pivoting locking arm which drops into a floor hole to lock a barricade in place.

Abstract: A microsurgical instrument including a handpiece defining a handpiece bore is provided. The instrument includes a first needle arranged at least partially within the handpiece bore, and an optical fiber extending through the handpiece bore and fixed to an interior of the first needle. The handpiece is rotatable relative to the optical fiber and the first needle.

Abstract: An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm2.

Abstract: A microsurgical instrument for illuminating an interior site includes an optical fiber having a length between opposed proximal and distal ends, wherein the proximal end of the optical fiber is configured for operative engagement with an illumination light source, the distal end of the optical fiber including a light emitting portion, a preformed curved portion of the optical fiber proximate to the distal end, wherein the curved portion has a predetermined bend or curve, a flexible tubular sleeve enclosing at least a portion of the optical fiber, wherein the tubular sleeve has a preformed curved portion corresponding to the curved portion of the optical fiber.

Abstract: The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, at least 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000, at least about 10,000, at least about 15,000, at least about 20,000, or at least about 25,000 proteins expressed in a species.

Abstract: Systems, kits and methods are disclosed for assessing epigenetic regulation of genome function via deoxyribonucleic acid (DNA) methylation status. The systems, kits and methods rely on a covert then capture concept in which unmethylated cytosine residues in a nucleic acid sequence are first converted to uracil residues and then captured for subsequent analysis. The systems, kits and method use a solution-phase capture probe pool having a mixture of at least three (3) types of capture probes. One type is “wobble” probes, in which some cytosine residues in a nucleic acid sequence are randomly assumed to be unmethylated and thus converted to uracil residues, while other cytosine residues are assumed to be methylated and thus conserved as cytosine residues. Moreover, each type of probe can include a mixture of probes that bind/hybridize to one or the other strand of a nucleic acid sequence of interest, thereby improving sequencing depth and reliability.

Abstract: The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.

Abstract: The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.

Abstract: The present invention is directed to a fence stake including a lateral rod side connected to a vertical rod at spaced intervals. An alternative embodiment includes bending the vertical stake in a complete reversal to also connect the end of the vertical rod to the lateral rod to provide a second connection location and directly transfer hammer blow to the lateral rod. A further alternative embodiment includes adding an angled rod that is connected to the lateral rod, connected to the vertical rod, or connected to both the lateral rod and the vertical rod.

Abstract: The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.

Abstract: The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.

Abstract: The invention is directed to a promoter isolated from maize. The promoter of the invention have particular utility in driving root preferred expression, specifically root-cap expression, of heterologous genes that impart increased agronomic, horticultural and/or pesticidal characteristics to a given transgenic plant. The invention is also drawn to DNA molecules comprising the promoter of the invention and transformed plant tissues containing DNA molecules comprising a promoter of the invention operably linked to a heterologous gene or genes, and seeds thereof.