Abstract: Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.

Abstract: Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.

Abstract: Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.

Abstract: A shaped lens for use with an LED device to produce a rectangular light pattern on a surface; wherein the LED device comprises a square extended area LED emitting surface (an emitter greater than 1 mm square). A refracting surface of the lens extends upward from a horizontal x-y plane having the square emitter extending horizontally and centered at the x-y-z origin, wherein the lens surface exhibits both two-axis orthogonal symmetry and 180 degree rotational symmetry about the central z-axis; and wherein the lens surface profile around the periphery of any horizontal section is generally rectangular with obtuse corner angles and is generally convex between corner angles; and further wherein the lens surface profile in any vertical section passing through the origin is generally convex upward and inward from the base plane through an apex and continuing convex downward and inward to an intermediate height end point at the z-axis.

Abstract: An illumination system, such as might be used for illuminating a projection system, includes at least a first source of incoherent light capable of generating light in a first wavelength range. The system includes at least one active chromophore layer, sandwiched by transparent materials into a multi-layer body. They active chromophore layer emits light in a second wavelength range, different from the first wavelength range, when illuminated by light in the first wavelength range. The multi-layer body has an extraction area and at least some of the light at the second wavelength is internally reflected within the body to the extraction area.

Abstract: An optical system has projector optics aligned on a projection axis that is orthogonal to an offset axis. A first laser is positioned in a first plane orthogonal to the projection axis. First folding optics are positioned in the first plane to fold a first beam from the first laser to a first portion of the projector optics. A second laser is in a second plane parallel to, and offset along the offset axis from, the first plane. Second folding optics is positioned in the second plane to fold a second beam from the second laser to a second portion of the projector optics to synthesize the first and second beam.

Abstract: An LED lighting apparatus and method provide efficient illumination in a downward and forward direction toward a preferential side, by mounting a plurality of LED devices to the apparatus in at least one horizontal row oriented perpendicularly to the downward and forward direction; mounting a vertical reflector behind and parallel to the horizontal row; and orienting the LED apparatus such that the vertical reflector extends substantially straight downward. A two axis orthogonally symmetric secondary lens is associated with each LED and the vertical reflector has a specular reflective front surface facing the LEDs. The vertical reflector may be curved around ends of the row of LEDs. Also it may be continued further downward, on the outside of a cover lens, by a backlight shield with a straight linear outer edge that extends horizontally across an uplight ring shield. The backlight shield may have a specular or diffuse reflecting front surface.

Abstract: Color sequential imaging involves illuminating, for each of two or more time-separated color fields, two or more light sources. Each of the two or more light sources emits at different wavelengths, and at least one of the first or second light sources is activated at different, non-zero current amplitudes during each of the first and second color fields. The color fields are projected via a spatial light modulator in synchronization with the activation of the at least one of the first or second light sources.

Abstract: An LED lighting apparatus and method provide efficient illumination in a downward and forward direction toward a preferential side, by mounting a plurality of LED devices to the apparatus in at least one horizontal row oriented perpendicularly to the downward and forward direction; mounting a vertical reflector behind and parallel to the horizontal row; and orienting the LED apparatus such that the vertical reflector extends substantially straight downward. A two axis orthogonally symmetric secondary lens is associated with each LED and the vertical reflector has a specular reflective front surface facing the LEDs. The vertical reflector may be curved around ends of the row of LEDs. Also it may be continued further downward, on the outside of a cover lens, by a backlight shield with a straight linear outer edge that extends horizontally across an uplight ring shield. The backlight shield may have a specular or diffuse reflecting front surface.

Abstract: An LED apparatus and method of operating the apparatus is provided for illumination toward a preferential side in a downward and forward direction. The LED apparatus includes a printed circuit board; a plurality of LED devices arranged in one or more horizontal rows and mounted to the printed circuit board; a secondary lens associated with each of the LED devices and being disposed on the printed circuit board; and a diffuse horizontal reflector disposed between the printed circuit board and the secondary lenses. The horizontal reflector may be made a diffuse reflector by providing a roughened bottom surface of the secondary lenses including flanges, thereby enabling the use of a specularly reflective material on the printed circuit board surface while still obtaining diffuse reflection.

Abstract: A projection system contains an illumination system having at least a first source of incoherent light capable of generating light in a first wavelength range. The illumination system also includes a body containing a fluorescent material that emits light in a second wavelength range, different from the first wavelength range, when illuminated by light in the first wavelength range. The system further includes at least a second fluorescent material that absorbs light in at least one of the first and second wavelength ranges, and emits light in a third wavelength range. The body has an extraction area, and at least some of the light in either the second or third wavelength ranges is internally reflected within the body to the extraction area. Light from the extraction area illuminates at least one image-forming device. Image light from the image-forming device is projected by a projection lens unit onto a screen.

Abstract: An illumination system, such as might be used for illuminating a projection system, includes at least a first source of incoherent light capable of generating light in a first wavelength range. The system includes at least one active chromophore layer, sandwiched by transparent materials into a multi-layer body. They active chromphore layer emits light in a second wavelength range, different from the first wavelength range, when illuminated by light in the first wavelength range. The multi-layer body has an extraction area and at least some of the light at the second wavelength is internally reflected within the body to the extraction area.

Abstract: Multi-directional optical elements are disclosed that include a body having a first side having a first curvature, a second side having a second curvature, a third side having a third curvature, and a fourth side having a fourth curvature. The second side is disposed generally opposite the first side along a first direction and a fourth side is disposed generally opposite the third side along a second direction, the second direction being different from the first direction. Also disclosed are optical systems utilizing such multi-directional optical elements.

Abstract: A projection system contains an illumination system having at least a first source of incoherent light capable of generating light in a first wavelength range. The illumination system also includes a body containing a fluorescent material that emits light in a second wavelength range, different from the first wavelength range, when illuminated by light in the first wavelength range. The system further includes at least a second fluorescent material that absorbs light in at least one of the first and second wavelength ranges, and emits light in a third wavelength range. The body has an extraction area, and at least some of the light in either the second or third wavelength ranges is internally reflected within the body to the extraction area. Light from the extraction area illuminates at least one image-forming device. Image light from the image-forming device is projected by a projection lens unit onto a screen.

Abstract: An illumination system, such as might be used for illuminating a projection system, includes at least a first source of incoherent light capable of generating light in a first wavelength range. The system also includes a body containing a fluorescent material that emits light in a second wavelength range, different from the first wavelength range, when illuminated by light in the first wavelength range. The body has an extraction area and at least some of the light at the second wavelength is internally reflected within the body to the extraction area.

Abstract: An embodiment of the invention is an illumination system including a source of incoherent light capable of generating light in a first wavelength range and an elongate body that emits light in a second wavelength range when illuminated by light in the first wavelength range. The body further includes an extraction surface. A first non-extraction surface extends along at least a portion of the length of the body and is disposed so as to share a common edge with the extraction surface. At least some of the light at the second wavelength is totally internally reflected at the non-extraction surface. At least one external reflector is disposed proximate to the non-extraction surface so as to create a gap of less than 100 microns between the external reflector and the non-extraction surface.

Abstract: An embodiment of the invention is an illumination system including a source of incoherent light capable of generating light in a first wavelength range and an elongate body that emits light in a second wavelength range when illuminated by light in the first wavelength range. The body has a length dimension, a width dimension and a height dimension. At least a portion of the body is tapered so as to increase in width and/or height along the length dimension. The body further includes an extraction surface. A first non-extraction surface extends along at least a portion of the length of the body and is disposed so as to share a common edge with the extraction surface. At least some of the light at the second wavelength is totally internally reflected at the non-extraction surface. At least one external reflector is disposed proximate to the non-extraction surface so as to create a gap between the external reflector and the non-extraction surface.

Abstract: A light guide and a projection system incorporating same are disclosed. The light guide includes a material that is capable of emitting light of a second wavelength when illuminated with light of a first wavelength where the first wavelength is different from the second wavelength. The light guide further includes an exit face that has a first portion that is reflective at the second wavelength and a second portion that is transmissive at the second wavelength. When the light guide is illuminated with light of the first wavelength, the material converts at least a portion of the light of the first wavelength into light of the second wavelength. The majority of the light of the second wavelength that exits the second portion of the exit face is totally internally reflected by the light guide.

Abstract: Illumination systems are disclosed, which include illumination channels of different colors and at least one image-forming device. Each illumination channel, in turn, includes a bank of light sources, and the image-forming device is disposed to receive illumination from at least one of the illumination channels. At least one of the illumination channels includes an optical element, such as an optical element having optical power or a homogenizing optical element, that is not shared with any other illumination channel and is preferentially constructed or preferentially positioned for the color of its illumination channel.

Abstract: Methods are provided for optimizing the spectrum of a light source used in a projection display system in order to reduce the light loss associated with color splitting/recombination in the system. Projection systems designed in accordance with such methods are also disclosed.