Abstract: Disclosed are compositions and methods for inhibiting aldehyde dehydrogenases. In further aspects, treatment of cancers by inhibiting aldehyde dehydrogenases with the disclosed compositions are also disclosed.

Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for using one or more schweinfurthin compounds and one or more immune-checkpoint inhibitors to treat a mammal having cancer are provided.

Abstract: Techniques allow runtime extensions to a whitelist that locks down a computational system. For example, executable code is not only subject to whitelist checks that allow (or deny) its execution, but is also subject to checks that determine whether a whitelisted executable is itself trusted to introduce further executable code into the computational system in which it is allowed to run. In general, deletion and/or modification of instances of code that are already covered by the whitelist are also disallowed in accordance with a security policy. Accordingly, an executable that is trusted may be allowed to delete and/or modify code instances covered by the whitelist. In general, trust may be coded for a given code instance that seeks to introduce, remove or modify code.

Abstract: Techniques have been developed to allow runtime extensions to a whitelist that locks down a computational system. For example, executable code (including e.g., objects such as a script or active content that may be treated as an executable) is not only subject to whitelist checks that allow (or deny) its execution, but is also subject to checks that determine whether a whitelisted executable is itself trusted to introduce further executable code into the computational system in which it is allowed to run. In general, deletion and/or modification of instances of code that are already covered by the whitelist are also disallowed in accordance with a security policy. Accordingly, an executable that is trusted may be allowed to delete and/or modify code instances covered by the whitelist. In general, trust may be coded for a given code instance that seeks to introduce, remove or modify code (e.g., in the whitelist itself).

Abstract: A processor programmed to write to a memory location a first weighted value corresponding to the processor to overwrite a second weighted value stored in the memory location and associated with another processor. The processor is also programmed to compare the first weighted value of the processor with the second weighted value associated with the other processor and to select the processor if the first weighted value of the processor is better than the second weighted value.

Abstract: System and method are disclosed for securing and managing individual end-user platforms as part of an enterprise network. The method/system of the invention has three main components: a security module, a manager appliance, and a console appliance. The security module enforces the enterprise licenses and security policies for the end-user platforms while the manager appliance provides secure, centralized communication with, and oversight of, the security module. The console appliance allows an administrator to access the manager appliance for purposes of monitoring and changing the licenses. Security is established and maintained through an innovative use of data encryption and authentication procedures. The use of these procedures allows the appliances to be uniquely identified to one another, which in turn provides a way to dynamically create unique identifiers for the security modules.