Abstract: An embodiment includes a method of computer software update in a managed network that includes endpoints having heterogenous operating systems. The method includes receiving a first update configured modify a first application on a first endpoint implementing a first non-Linux-based operating system (OS) and first metadata associated therewith. The method includes generating a first update package based on the first metadata and distributing the first update and the first update package to the first endpoint. The method includes accessing a product update list identifying a second application in an unpatched state on the second endpoint implementing a Linux-based OS and repository information of a repository device. Based on the repository information, the method includes accessing the second update and second metadata associated therewith. The method includes generating a second update package and distributing it and the second update such that the second endpoint locally implements the second update.

Abstract: Disclosed are compositions and methods for inhibiting aldehyde dehydrogenases. In further aspects, treatment of cancers by inhibiting aldehyde dehydrogenases with the disclosed compositions are also disclosed.

Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for using one or more schweinfurthin compounds and one or more immune-checkpoint inhibitors to treat a mammal having cancer are provided.

Abstract: Techniques allow runtime extensions to a whitelist that locks down a computational system. For example, executable code is not only subject to whitelist checks that allow (or deny) its execution, but is also subject to checks that determine whether a whitelisted executable is itself trusted to introduce further executable code into the computational system in which it is allowed to run. In general, deletion and/or modification of instances of code that are already covered by the whitelist are also disallowed in accordance with a security policy. Accordingly, an executable that is trusted may be allowed to delete and/or modify code instances covered by the whitelist. In general, trust may be coded for a given code instance that seeks to introduce, remove or modify code.

Abstract: Techniques have been developed to allow runtime extensions to a whitelist that locks down a computational system. For example, executable code (including e.g., objects such as a script or active content that may be treated as an executable) is not only subject to whitelist checks that allow (or deny) its execution, but is also subject to checks that determine whether a whitelisted executable is itself trusted to introduce further executable code into the computational system in which it is allowed to run. In general, deletion and/or modification of instances of code that are already covered by the whitelist are also disallowed in accordance with a security policy. Accordingly, an executable that is trusted may be allowed to delete and/or modify code instances covered by the whitelist. In general, trust may be coded for a given code instance that seeks to introduce, remove or modify code (e.g., in the whitelist itself).

Abstract: System and method are disclosed for securing and managing individual end-user platforms as part of an enterprise network. The method/system of the invention has three main components: a security module, a manager appliance, and a console appliance. The security module enforces the enterprise licenses and security policies for the end-user platforms while the manager appliance provides secure, centralized communication with, and oversight of, the security module. The console appliance allows an administrator to access the manager appliance for purposes of monitoring and changing the licenses. Security is established and maintained through an innovative use of data encryption and authentication procedures. The use of these procedures allows the appliances to be uniquely identified to one another, which in turn provides a way to dynamically create unique identifiers for the security modules.

Abstract: System and method are disclosed for securing and managing individual end-user platforms as part of an enterprise network. The method/system of the invention has three main components: a security module, a manager appliance, and a console appliance. The security module enforces the enterprise licenses and security policies for the end-user platforms while the manager appliance provides secure, centralized communication with, and oversight of, the security module. The console appliance allows an administrator to access the manager appliance for purposes of monitoring and changing the licenses. Security is established and maintained through an innovative use of data encryption and authentication procedures. The use of these procedures allows the appliances to be uniquely identified to one another, which in turn provides a way to dynamically create unique identifiers for the security modules.

Abstract: System and method are disclosed for securing and managing individual end-user platforms as part of an enterprise network. The method/system of the invention has three main components: a security module, a manager appliance, and a console appliance. The security module enforces the enterprise licenses and security policies for the end-user platforms while the manager appliance provides secure, centralized communication with, and oversight of, the security module. The console appliance allows an administrator to access the manager appliance for purposes of monitoring and changing the licenses. Security is established and maintained through an innovative use of data encryption and authentication procedures. The use of these procedures allows the appliances to be uniquely identified to one another, which in turn provides a way to dynamically create unique identifiers for the security modules.