Patents by Inventor Todd W. Chappell

Todd W. Chappell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20230190696
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: February 8, 2023
    Publication date: June 22, 2023
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical formulation for histone deacetylase inhibitors
    Patent number: 11607399
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: March 21, 2023
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20210038555
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: July 9, 2020
    Publication date: February 11, 2021
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20190175539
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 13, 2019
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical formulation for histone deacetylase inhibitors
    Patent number: 10258595
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: April 16, 2019
    Assignee: Medivir AB
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20170360741
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: June 29, 2017
    Publication date: December 21, 2017
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20160106700
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: December 30, 2015
    Publication date: April 21, 2016
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical formulation for histone deacetylase inhibitors
    Patent number: 9255066
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: February 9, 2016
    Assignee: TetraLogic Shape UK Ltd
    Inventors: Todd W. Chappell, Keith A. Johnson
  • Pharmaceutical Formulation for Histone Deacetylase Inhibitors
    Publication number: 20130203847
    Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.
    Type: Application
    Filed: October 13, 2011
    Publication date: August 8, 2013
    Applicant: SHAPE PHARMACEUTICALS, INC.
    Inventors: Todd W. Chappell, Keith A. Johnson
  • METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF OPHTHALMIC DISORDERS
    Publication number: 20120322746
    Abstract: The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 20, 2012
    Applicant: Zalicus, Inc.
    Inventors: Todd W. Chappell, M. James Nichols, Daniel S. Grau
  • Methods, compositions, and kits for the treatment of ophthalmic disorders
    Patent number: 8258153
    Abstract: The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 4, 2012
    Assignee: Zalicus, Inc.
    Inventors: Todd W. Chappell, M. James Nichols, Daniel S. Grau
  • METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF OPHTHALMIC DISORDERS
    Publication number: 20120077756
    Abstract: The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant.
    Type: Application
    Filed: November 28, 2011
    Publication date: March 29, 2012
    Applicant: Zalicus Inc.
    Inventors: Todd W. Chappell, M. James Nichols, Daniel S. Grau
  • Methods, compositions, and kits for the treatment of ophthalmic disorders
    Patent number: 8067433
    Abstract: The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: November 29, 2011
    Assignee: Zalicus Inc.
    Inventors: Todd W. Chappell, M. James Nichols, Daniel S. Grau
  • COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
    Publication number: 20100009970
    Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 14, 2010
    Applicant: Combinatorx (Singapore) Pte. Ltd.
    Inventors: Lisa M. Johansen, Christopher M. Owens, Christina Mawhinney, Todd W. Chappell, Alexander T. Brown, Michael G. Frank, Michael A. Foley, Ralf Altmeyer, Yu Chen
  • Compositions and methods for treatment of viral diseases
    Publication number: 20080161324
    Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
    Type: Application
    Filed: September 13, 2007
    Publication date: July 3, 2008
    Inventors: Lisa M. Johansen, Christopher M. Owens, Christina Mawhinney, Todd W. Chappell, Alexander T. Brown, Michael G. Frank, Ralf Altmeyer
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040229849
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 18, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell
  • Combination therapy for the treatment of immunoinflammatory disorders
    Publication number: 20040224876
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and an NsIDI enhancer (NsIDIE) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and NsIDIE or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 11, 2004
    Inventors: Edward Roydon Jost-Price, Bradley B. Brasher, Todd W. Chappell, Palaniyandi Manivasakam, Noah Sachs, Brendan Smith, Benjamin A. Auspitz
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040220153
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 24, 2003
    Publication date: November 4, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell
  • Combinations for the treatment of fungal infections
    Publication number: 20040157837
    Abstract: The invention features methods and compositions for treating a patient diagnosed with, or at risk for developing, a fungal infection.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 12, 2004
    Inventors: George N. Serbedzija, Lisa M. Johansen, Todd W. Chappell, Curtis Keith, Grant R. Zimmermann, M. James Nichols, Benjamin A. Auspitz