Patents by Inventor Todd Zachary DESANTIS

Todd Zachary DESANTIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115625
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacteria Rosburia hominis and Eubacterium eligens and their uses in treating metabolic-related diseases or disorders.
    Type: Application
    Filed: February 21, 2023
    Publication date: April 11, 2024
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Mitsuko Lynn Yamamoto, Todd Zachary DeSantis, Karim Dabbagh
  • Publication number: 20240076323
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: July 18, 2023
    Publication date: March 7, 2024
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Publication number: 20240066095
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: April 24, 2023
    Publication date: February 29, 2024
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh, Toshihiko Takeuchi, Ye Jin, Michi Izumi Willcoxon, Stefanie Banas
  • Publication number: 20240043477
    Abstract: The disclosure related to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: December 9, 2022
    Publication date: February 8, 2024
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Patent number: 11666627
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: June 6, 2023
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Tarunmeet Gujral, Todd Zachary Desantis, Karim Dabbagh, Toshihiko Takeuchi, Ye Jin, Michi Izumi Willcoxon, Stefanie Banas
  • Publication number: 20230031818
    Abstract: Methods and compositions are provided herein for treating colorectal cancer in a subject, using one or more bacterial strains such as Bacteroides eggerthii 1 2 48FAA, Bacteroides eggerthii CCUG 9559, Bacteroides goldsteinii ATCC BAA 1180, Bacteroides pectinophilus N3, Bacteroides plebeius M12, Bacteroides vulgatus 8482, Barnesiella intestinihominis DSM 21032, Bifidobacterium stercoris EG1, Clostridium sp. 40, Clostridium spiroforme CCM 6168, Eubacterium eligens DSM 3376, Eubacterium hallii DSM 3353, Megamonas funiformis DSM 19343, Megasphaera elsdenii LC1, Parabacteroides johnsonii M-165, Butyricimonas virosa MT12, Clostridium citroniae DSM 19261, Lactobacillus ruminis RF3, Methanosphaera stadtmanae MCB-3, Ruminococcus sp. 18P13, Slackia piriformis DSM 22477, or Streptococcus hongkongensis HKU30.
    Type: Application
    Filed: January 15, 2021
    Publication date: February 2, 2023
    Inventors: Jayamary Divya Ravichandar, Todd Zachary DeSantis
  • Publication number: 20230030056
    Abstract: Methods and compositions are provided herein for treating and/or diagnosing ulcerative colitis in a subject, using one or more bacterial strains such as Bacillus sp. BT1B_CT2, Bacteroides coprocola M16, Bacteroides eggerthii CCUG 9559, Bacteroides vulgatus 8482, Butyricimonas virosa MT12, Coprococcus eutactus ATCC 27759, Desulfovibrio piger DSM 749, Dolosigranulum pigrum IFO 15550, Eubacterium biforme DSM 3989, Eubacterium eligens DSM 3376, Fusobacterium prausnitzii ATCC 27768, Howardella ureilytica GPC 589, Megasphaera elsdenii LC1, Parabacteroides johnsonii M-165, Phascolarctobacterium sp. YIT 12067, Roseburia hominus A2-183, or Ruminococcus callidus VPI 57-31.
    Type: Application
    Filed: January 15, 2021
    Publication date: February 2, 2023
    Inventors: Jayamary Divya Ravichandar, Andrew Wonhee Han, Todd Zachary DeSantis, Cheryl-Emiliane T. Chow
  • Publication number: 20220257703
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: March 10, 2022
    Publication date: August 18, 2022
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Patent number: 11389487
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacterium Streptococcus australis and their uses in treating metabolic-related diseases or disorder.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: July 19, 2022
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Bernat Baeza Raja, Shoko Kawana, Mitsuko Lynn Yamamoto, Karim Dabbagh, Todd Zachary DeSantis
  • Publication number: 20220185849
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 16, 2022
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Patent number: 11344584
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacterium Gemella sanguinis and their uses in treating metabolic-related diseases or disorder.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: May 31, 2022
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Bernat Baeza Raja, Shoko Kawana, Mitsuko Lynn Yamamoto, Karim Dabbagh, Todd Zachary DeSantis
  • Publication number: 20220106365
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: November 15, 2021
    Publication date: April 7, 2022
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Patent number: 11273198
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: March 15, 2022
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Patent number: 11207376
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: December 28, 2021
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Tarunmeet Gujral, Todd Zachary Desantis, Karim Dabbagh, Toshihiko Takeuchi, Ye Jin, Michi Izumi Willcoxon, Stefanie Banas
  • Patent number: 11174293
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: November 16, 2021
    Assignee: Second Genome, Inc.
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Publication number: 20200376044
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacteria Rosburia hominis and Eubacterium eligens and their uses in treating metabolic-related diseases or disorders.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 3, 2020
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Mitsuko Lynn Yamamoto, Todd Zachary DeSantis, Karim Dabbagh
  • Publication number: 20200237829
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacterium Streptococcus australis and their uses in treating metabolic-related diseases or disorder.
    Type: Application
    Filed: August 6, 2018
    Publication date: July 30, 2020
    Inventors: Andrew Wonhee Han, Bernat Baeza Raja, Shoko Kawana, Mitsuko Lynn Yamamoto, Karim Dabbagh, Todd Zachary DeSantis
  • Publication number: 20200237830
    Abstract: The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacterium Gemella sanguinis and their uses in treating metabolic-related diseases or disorder.
    Type: Application
    Filed: August 6, 2018
    Publication date: July 30, 2020
    Inventors: Andrew Wonhee Han, Bernat Baeza Raja, Shoko Kawana, Mitsuko Lynn Yamamoto, Karim Dabbagh, Todd Zachary DeSantis
  • Publication number: 20200181206
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: June 1, 2018
    Publication date: June 11, 2020
    Inventors: Andrew Wonhee Han, Andrew Whitman Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
  • Publication number: 20200171125
    Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: January 28, 2019
    Publication date: June 4, 2020
    Inventors: Andrew Wonhee HAN, Andrew Whitman GOODYEAR, Tarunmeet GUJRAL, Todd Zachary DESANTIS, Karim DABBAGH, Toshihiko TAKEUCHI, Ye JIN, Michi Izumi WILLCOXON, Stefanie BANAS