Patents by Inventor Todd Zankel

Todd Zankel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
    Patent number: 10716862
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering front a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 21, 2020
    Assignee: BiOasis Advanced Technologies Inc.
    Inventors: Christopher M. Starr, Todd Zankel
  • USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES
    Publication number: 20200188522
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either side of the blood brain barrier.
    Type: Application
    Filed: October 18, 2019
    Publication date: June 18, 2020
    Inventors: Christopher M. Starr, Todd Zankel
  • USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES
    Publication number: 20180021445
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering front a lysosomal storage disease a P97 conjugated with art enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Application
    Filed: February 28, 2017
    Publication date: January 25, 2018
    Inventors: Christopher M. Starr, Todd Zankel
  • USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES
    Publication number: 20140105880
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain harrier.
    Type: Application
    Filed: August 16, 2013
    Publication date: April 17, 2014
    Inventors: Christopher M. Starr, Todd Zankel
  • Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
    Patent number: 8546319
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: October 1, 2013
    Assignee: biOasis Advanced Technologies Inc.
    Inventors: Christopher M. Starr, Todd Zankel
  • Megalin-Based Delivery of Therapeutic Compounds to the Brain and Other Tissues
    Publication number: 20110142763
    Abstract: The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
    Type: Application
    Filed: November 8, 2010
    Publication date: June 16, 2011
    Applicant: Raptor Pharmaceuticals Inc.
    Inventors: TODD ZANKEL, CHRISTOPHER M. STARR
  • Use of p97 As An Enzyme Delivery System For The Delivery of Therapeutic Lysosomal Enzymes
    Publication number: 20100303797
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Application
    Filed: March 23, 2010
    Publication date: December 2, 2010
    Applicant: BIOASIS TECHNOLOGIES INC.
    Inventors: Christopher M. Starr, Todd Zankel
  • MEGALIN-BASED DELIVERY OF THERAPEUTIC COMPOUNDS TO THE BRAIN AND OTHER TISSUES
    Publication number: 20100028370
    Abstract: The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
    Type: Application
    Filed: July 24, 2009
    Publication date: February 4, 2010
    Applicant: RAPTOR PHARMACEUTICAL INC.
    Inventors: TODD ZANKEL, Christopher M. Starr
  • Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents
    Patent number: 7569544
    Abstract: The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: August 4, 2009
    Assignee: Raptor Pharmaceutical Inc.
    Inventors: Todd Zankel, Christopher M. Starr
  • Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents
    Patent number: 7560431
    Abstract: This invention provides compounds of conjugates of therapeutic or active agents with RAP or a RAP polypeptide, their pharmaceutical compositions and methods for using the such compounds and compositions in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly diseases of the central nervous system or lysosomal storage diseases.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: July 14, 2009
    Assignee: Raptor Pharmaceutical Inc.
    Inventors: Todd Zankel, Christopher M. Starr, Reinhard Gabathuler
  • Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
    Publication number: 20060029609
    Abstract: This invention provides compounds of conjugates of therapeutic or active agents with RAP or a RAP polypeptide, their pharmaceutical compositions and methods for using the such compounds and compositions in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly diseases of the central nervous system or lysosomal storage diseases.
    Type: Application
    Filed: August 12, 2005
    Publication date: February 9, 2006
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Todd Zankel, Christopher Starr, Reinhard Gabathuler
  • Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
    Publication number: 20050158296
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Application
    Filed: January 10, 2003
    Publication date: July 21, 2005
    Inventors: Christopher Starr, Todd Zankel
  • Megalin-based delivery of therapeutic compounds to the brain and other tissues
    Publication number: 20050042227
    Abstract: The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
    Type: Application
    Filed: March 30, 2004
    Publication date: February 24, 2005
    Inventors: Todd Zankel, Christopher Starr
  • Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
    Publication number: 20050026823
    Abstract: This invention provides compounds of conjugates of therapeutic or active agents with RAP or a RAP polypeptide, their pharmaceutical compositions and methods for using the such compounds and compositions in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly diseases of the central nervous system or lysosomal storage diseases.
    Type: Application
    Filed: June 20, 2003
    Publication date: February 3, 2005
    Applicant: BioMarin Pharmaceutical Inc.
    Inventors: Todd Zankel, Christopher Starr, Reinhard Gabathuler