Patents by Inventor Togapur Pavan Kumar
Togapur Pavan Kumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932654Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: February 9, 2021Date of Patent: March 19, 2024Assignee: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 11306100Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.Type: GrantFiled: March 9, 2018Date of Patent: April 19, 2022Inventors: Prathama S. Mainkar, Mohammad Abdul Sattar, Pitchakuntla Mallesham, Togapur Pavan Kumar, Divya Duscharla, Ummanni Ramesh, Srivari Chandrasekhar
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Publication number: 20210284650Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.Type: ApplicationFiled: March 9, 2018Publication date: September 16, 2021Inventors: Prathama S. MAINKAR, Mohammad Abdul SATTAR, Pitchakuntla MALLESHAM, Togapur Pavan KUMAR, Divya DUSCHARLA, Ummanni RAMESH, Srivari CHANDRASEKHAR
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Publication number: 20210171538Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: February 9, 2021Publication date: June 10, 2021Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 10947249Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: October 26, 2018Date of Patent: March 16, 2021Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 10421739Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclization and methylation.Type: GrantFiled: January 6, 2017Date of Patent: September 24, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar
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Publication number: 20190211027Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: October 26, 2018Publication date: July 11, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20190016699Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclisation and methylation.Type: ApplicationFiled: January 6, 2017Publication date: January 17, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar
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Patent number: 9963476Abstract: The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE?/? mice along with the endothelial cell age-delaying effects of Mito-Esc.Type: GrantFiled: February 27, 2017Date of Patent: May 8, 2018Assignee: Council of Scientific and Industrial ResearchInventors: Kotamraju Srigiridhar, Karnewar Santosh, Vasamsetti Sathish Babu, Togapur Pavan Kumar, Basi Venkata Subba Reddy, Jerald Mahesh Kumar
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Publication number: 20170240577Abstract: The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE?/? mice along with the endothelial cell age-delaying effects of Mito-Esc.Type: ApplicationFiled: February 27, 2017Publication date: August 24, 2017Inventors: Kotamraju Srigiridhar, Karnewar Santosh, Vasamsetti Sathish Babu, Togapur Pavan Kumar, Basi Venkata Subba Reddy, Jerald Mahesh Kumar
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Patent number: 9580452Abstract: The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE?/?) mice along with the endothelial cell age-delaying effects of Mito-Esc.Type: GrantFiled: February 19, 2016Date of Patent: February 28, 2017Assignee: Council of Scientific and Industrial ResearchInventors: Kotamraju Srigiridhar, Karnewar Santosh, Vasamsetti Sathish Babu, Togapur Pavan Kumar, Basi Venkata Subba Reddy, Jerald Mahesh Kumar
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Publication number: 20160244470Abstract: The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE?/?) mice along with the endothelial cell age-delaying effects of Mito-Esc.Type: ApplicationFiled: February 19, 2016Publication date: August 25, 2016Inventors: Kotamraju Srigiridhar, Karnewar Santosh, Vasamsetti Sathish Babu, Togapur Pavan Kumar, Basi Venkata Subba Reddy, Jerald Mahesh Kumar