Patents by Inventor Tokiyoshi Matsushita

Tokiyoshi Matsushita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190106748
    Abstract: Provided is a method for measuring an Alu RNA level in blood by (1) carrying out a reverse transcription reaction on RNA extracted from a blood sample collected from a subject as a template, using a reverse transcription primer having a poly dT sequence and a universal tag sequence at the 5? side of the poly dT sequence, to synthesize cDNA, and (2) carrying out PCR amplification on the cDNA synthesized in step (1) as a template, using a forward primer consisting of a nucleotide sequence comprising at least 15 contiguous nucleotides from a nucleotide sequence consisting of nucleotides at positions 1 to 117 in the nucleotide sequence as set forth in SEQ ID NO: 1 and a reverse primer consisting of a complementary sequence to the universal tag sequence or a partial sequence thereof, and measuring an Alu RNA level based on an amount of the amplification product.
    Type: Application
    Filed: March 24, 2017
    Publication date: April 11, 2019
    Applicant: Santen Pharmaceutical Co., Ltd
    Inventor: Tokiyoshi Matsushita
  • Publication number: 20120101046
    Abstract: Intravitreal administration of a JNK-inhibitory peptide less than 150 amino acids in length, containing at least one D-amino acid, and having (a) a JNK-inhibitory sequence of at least any of SEQ ID NO: 1 and SEQ ID NO: 2, and (b) a transport sequence of at least any of SEQ ID NO: 3 and SEQ ID NO: 4 suppressed spermidine-induced retinal pigment epithelial damage, tunicamycin-induced photoreceptor cell damage, and laser-induced choroidal neovascularization. Thus, the JNK-inhibitory peptide of the present invention is useful for prophylaxis or therapy of a retinal disease. By the use of this JNK-inhibitory peptide, a drug and a method are provided which are capable of preventing or treating a retinal disease even by topical administration to the eye, and use of the JKN-inhibitory peptide for manufacturing the drug is also provided.
    Type: Application
    Filed: March 25, 2010
    Publication date: April 26, 2012
    Inventors: Shin-ichiro Hirai, Tokiyoshi Matsushita, Yukie Fujita, Hiroaki Kurashima, Kouji Oohashi