Patents by Inventor Tokuhiro Okada

Tokuhiro Okada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5684584
    Abstract: The present invention relates to an apparatus for automatically analyzing cells in urine using flow cytometry. The present invention includes means for converting scattered-light signals indicative of individual cells in a urine specimen into corresponding pulse signals, means for converting the pulse width of each pulse signal resulting from the aforementioned conversion into cell-diameter data in accordance with known cell diameters, and means for classifying and enumerating various cells in the urine in correlation with each item of cell-diameter data resulting from the conversion.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 4, 1997
    Assignee: TOA Medical Electronics Co., Ltd.
    Inventors: Hiroyuki Nakamoto, Tokuhiro Okada
  • Patent number: 5325169
    Abstract: A method and apparatus are provided for analyzing cells in urine. A constricted zone through which various cells contained in a urine specimen flow in single file is irradiated with light having a light beam width in the direction of cell flow of between 1 .mu.m to 20 .mu.m. Scattered light and fluorescent light emitted by the cells is converted into scattered-light intensity data and fluorescent light intensity data. Preferably, the individual cells have been stained with a stain such that DNA will specifically emit fluorescence. Cell diameter data and peak-count data are also generated from the detected scattered light. Cell judgement values are stored in a memory device, and the cells in the urine specimen are classified based upon the cell judgement values.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: June 28, 1994
    Assignee: TOA Medical Electronics Co., Ltd.
    Inventors: Hiroyuki Nakamoto, Tokuhiro Okada
  • Patent number: 5325168
    Abstract: A method and apparatus are provided for analyzing cells in urine. A constricted zone through which various cells contained in a urine specimen flow in single file is irradiated with light having a light beam width in the direction of cell flow of between 1 .mu.m to 20 .mu.m. Scattered light and fluorescent light emitted by the cells is converted into scattered-light intensity data and fluorescent light intensity data. Preferably, the individual cells have been stained with a stain such that DNA will specifically emit fluorescence. Cell diameter data is also generated from the detected scattered light. Cell judgment values are stored in a memory device, and the cells in the urine specimen are classified based upon the cell judgment values.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: June 28, 1994
    Assignee: TOA Medical Electronics Co., Ltd.
    Inventors: Hiroyuki Nakamoto, Tokuhiro Okada
  • Patent number: 5059395
    Abstract: In particle analysis applied to blood cells, use is made of a distinguishing parameter which is the ratio of pulse height to pulse width derived from individual pulses generated in response to detection of corresponding individual particles. The distribution of the distinguishing parameter is plotted on a distribution of pulse height and pulse width, and a three-dimensional display of pulse height, pulse width and the distinguishing parameter is used in analyzing the particles.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: October 22, 1991
    Assignee: Toa Medical Electronics Co., Ltd.
    Inventors: Gary M. Brittenham, Christopher J. Allen, Tokuhiro Okada, Keiji Fujimoto
  • Patent number: 4491926
    Abstract: A particle size distribution analyzer includes a detector adapted to detect particles by electrical or optical differences from a medium containing the particles in dispersion and generate signals proportionally to the sizes of the detected particles, a threshold circuit adapted to remove noises or fragmental signals from the detected signals so as to obtain pulse widths at a constant position, a gate circuit adapted to decide the passage or non-passage of the particles through the threshold circuit, a counter circuit adapted to count the number of the particles fed from the gate circuit, a memory connected to the counter circuit, an arithmetic circuit connected to the memory and the detector, a controller circuit connected to the gate circuit, the memory and the counter circuit, and means for displaying or recording the data stored in the memory.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: January 1, 1985
    Assignee: Toa Medical Electronics Co. Ltd.
    Inventors: Tokuhiro Okada, Masayoshi Hayashi
  • Patent number: 4488248
    Abstract: A particle size distribution analyzer comprising a particle detector adapted to produce signals in response to the sizes of particles by electrical or optical differences between a liquid and the particles dispersed therein, a plurality of comparators connected in parallel to said particle detector for producing pulses in correspondence with said signals, counters connected to each of said comparators for counting said pulses, a data input/output unit connected to each individual counter, whereby said input/output circuit receives signals sent in parallel from said counters, a keyboard unit connected to said input/output circuit operative to enable various conditions to be input from the outside, a central processing unit circuit, a read only memory and, a random access memory connected to said later input/output unit for statistically processing the pulse received, and a data output unit connected to said data input/output unit, said data output unit including at least a recorder.
    Type: Grant
    Filed: December 10, 1982
    Date of Patent: December 11, 1984
    Assignee: Toa Medical Electronics Co., Ltd.
    Inventors: Tokuhiro Okada, Masayoshi Hayashi, Hideaki Matsumoto