Patents by Inventor Tokuji Ikenaka

Tokuji Ikenaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for measuring analyte in sample
    Patent number: 5545530
    Abstract: The amount of an analyte in a sample derived from a living sample is measured by reacting the analyte with an excess of a substance having affinity for the analyte, followed by separation of complex by high pressure liquid chromatography and measurement using a linear calibration curve representing the peak area values associated with known concentrations of analyte.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: August 13, 1996
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Shinji Satomura, Kenji Nakamura, Tokuji Ikenaka, Kaoru Omichi
  • Method of differential assay for .alpha.-amylase isozymes and a kit for the same
    Patent number: 5350678
    Abstract: Differential assay of human pancreatic .alpha.-amylase and human salivary .alpha.-amylase can be made extremely easily with good accuracy using a reducing-end modified maltooligosaccharide derivative as a substrate, by acting coupled enzymes having different substrate specificities on the degradation products formed by the hydrolytic action of .alpha.-amylases and measuring the resulting reaction products.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: September 27, 1994
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi
  • .alpha.-amylase assay using modified oligosaccharide and process for producing said modified oligosaccharide
    Patent number: 5319078
    Abstract: .alpha.-Amylase activity can be determined rapidly and precisely by using as a substrate a modified oligo-saccharide wherein a benzylozymethyl group or a halo-methyl group is bonded to the C.sub.6 position of non-reducing-end glucose residue and the reducing-end glucose residue is bonded to a group which exhibits an optically measurable change upon cleavage. Processes for producing such a compound are also disclosed.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: June 7, 1994
    Assignee: Wako Pure Chemical Industries, Inc.
    Inventors: Tokuji Ikenaka, Kaoru Omichi, Shinji Satomura, Yuko Nagamine
  • .alpha.-amylase assay using modified oligosaccharide and process for producing said modified oligosaccharide
    Patent number: 5192666
    Abstract: .alpha.-Amylase activity can be determined rapidly and precisely by using as a substrate a modified oligosaccharide wherein a benzyloxymethyl group or a halomethyl group is bonded to the C.sub.6 position of non-reducing-end glucose residue and the reducing-end glucose residue is bonded to a group which exhibits an optically measurable change upon cleavage. Processes for producing such a compound are also disclosed.
    Type: Grant
    Filed: December 29, 1989
    Date of Patent: March 9, 1993
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi, Shinji Satomura, Yuko Nagamine
  • Peptide derivatives and activity measuring method of physiologically active substances using the same as substrates
    Patent number: 5120644
    Abstract: Activities of physiologically active substances such as endopeptidases, proteases, transferases, phosphatases, protein kinase and the like enzymes can be measured specifically with high sensitivity by using as a substrate a peptide derivative having 2 to 15 amino acid units and a group which can emit fluoresence and/or absorb ultraviolet light as at least one terminal group.
    Type: Grant
    Filed: October 6, 1988
    Date of Patent: June 9, 1992
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Tomohiro Mega, Yasuki Hamazume
  • Oligosaccharide derivatives and their use as substrate for measuring .alpha .
    Patent number: 4762917
    Abstract: An oligosaccharide derivative having 4 to 7 glucose units wherein a primary alcohol moiety positioned at the 6-position of the non-reducing end glucose unit is replaced by ##STR1## --CH.sub.2 OCH.sub.2 COOH, or the like group and the 1-position of the reducing end glucose unit is replaced by a phenoxy or substituted phenoxy group or an umbelliferyl group or an indoxyl group is particularly suitable as a substrate for measuring .alpha.-amylase activity.
    Type: Grant
    Filed: August 13, 1985
    Date of Patent: August 9, 1988
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi
  • Modified oligosaccharides used as substrate for measuring .alpha.-amylase activity
    Patent number: 4697006
    Abstract: A modified oligosaccharide having at most 7 glucose units and having a substituent selected from the group consisting of 2-aminopyridyl, 3-aminopyridyl, anilino, methylanilino, hydroxyanilino, carboxyphenylamino and hydroxyl groups at at least one end moiety of said oligosaccharide is suitable as substrate for measuring .alpha.-amylase activity or for measuring .alpha.-amylase isozymes.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: September 29, 1987
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi
  • Modified oligosaccharides used as substrate for measuring .alpha.-amylase activity
    Patent number: 4622295
    Abstract: A modified oligosaccharide having at most 7 glucose units and having a substituent selected from the group consisting of 2-aminopyridyl, 3-aminopyridyl, anilino, methylanilino, hydroxyanilino, carboxyphenylamino and hydroxyl groups at at least one end moiety of said oligosaccharide is suitable as substrate for measuring .alpha.-amylase activity or for measuring .alpha.-amylase isozymes.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: November 11, 1986
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tokuji Ikenaka, Kaoru Omichi