Patents by Inventor Tokuyuki Shinohara

Tokuyuki Shinohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING T CELLS
    Publication number: 20220411752
    Abstract: Provided is an excellent method for producing an IL-4 non-secreting and IFN-? secreting (Th1-type) or IFN-? non-secreting and IL-4 secreting (Th2-type) CD4 single-positive T cell (CD4SP T cell). The method for producing the Th1-type or Th2-type CD4SP T cell of the present invention comprises a step of inducing a CD4 single-positive T cell from a hematopoietic stem cell (HSC) and/or a hematopoietic progenitor cell (HPC) substantially defective in a factor involved in IL-4 secretion or a factor involved in IFN-? secretion.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 29, 2022
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Shin KANEKO, Hisashi YANO, Tokuyuki SHINOHARA
  • IL-13 production inhibitor
    Patent number: 7951548
    Abstract: The present invention provides a screening method/screening kit for an IL-13 production inhibitor, which comprises using (a) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a salt thereof; and (b) a ligand capable of specifically binding to the protein; an IL-13 production inhibitor which is obtainable by said screening, and the like. The IL-13 production inhibitor which can be obtained by the screening of the present invention is useful as a prophylactic/therapeutic agent for, e.g., respiratory disease, etc.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: May 31, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Kazuhiro Ogi, Yusuke Kikukawa, Tsukasa Sugo, Tokuyuki Shinohara
  • IL-13 Production Inhibitor
    Publication number: 20090170116
    Abstract: The present invention provides a screening method/screening kit for an IL-13 production inhibitor, which comprises using (a) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a salt thereof; and (b) a ligand capable of specifically binding to the protein; an IL-13 production inhibitor which is obtainable by said screening, and the like. The IL-13 production inhibitor which can be obtained by the screening of the present invention is useful as a prophylactic/therapeutic agent for, e.g., respiratory disease, etc.
    Type: Application
    Filed: February 15, 2006
    Publication date: July 2, 2009
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Kazuhiro Ogi, Yusuke Kikukawa, Tsukasa Sugo, Tokuyuki Shinohara
  • Novel screening method
    Publication number: 20060073516
    Abstract: Using a novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 2 or its salt together with ?-alanine or L-carnosine, an agonist or an antagonist to the receptor protein or its salt can be efficiently screened.
    Type: Application
    Filed: March 27, 2003
    Publication date: April 6, 2006
    Inventors: Yasuaki Ito, Tokuyuki Shinohara, Masaki Hosoya, Shuji Hinuma, Yuko Noguchi