Patents by Inventor Tokuyuki YOSHIDA

Tokuyuki YOSHIDA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME
    Publication number: 20230340008
    Abstract: Disclosed are a bridged nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The bridged nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The bridged nucleoside also has excellent industrial productivity.
    Type: Application
    Filed: February 18, 2021
    Publication date: October 26, 2023
    Inventors: Satoshi OBIKA, Takao YAMAGUCHI, Hibiki KOMINE, Takaya SUGIURA, Takao INOUE, Tokuyuki YOSHIDA
  • CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME
    Publication number: 20230124641
    Abstract: A cross-linked nucleoside of the present invention is a compound represented by the formula (I) below. The cross-linked nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The cross-linked nucleoside also has excellent industrial productivity.
    Type: Application
    Filed: February 17, 2021
    Publication date: April 20, 2023
    Inventors: Satoshi OBIKA, Takao YAMAGUCHI, Yota SAKURAI, Chika YAMAMOTO, Kei SUGITA, Takao INOUE, Tokuyuki YOSHIDA
  • 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME
    Publication number: 20220372060
    Abstract: Disclosed are a 5?-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5?-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5?-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.
    Type: Application
    Filed: January 31, 2020
    Publication date: November 24, 2022
    Inventors: Satoshi OBIKA, Takao YAMAGUCHI, Takaki HABUCHI, Go KATO, Takao INOUE, Tokuyuki YOSHIDA, Takaya SUGIURA
  • ANTISENSE OLIGONUCLEIC ACID
    Publication number: 20220170020
    Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2?,4?-bridged nucleic acids, 2?,4?-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2?,4?-non-bridged nucleic acid residue(s) is/are modified.
    Type: Application
    Filed: February 7, 2022
    Publication date: June 2, 2022
    Applicant: Osaka University
    Inventors: Satoshi OBIKA, Reiko WAKI, Takao INOUE, Tokuyuki YOSHIDA, Kunihiko MORIHIRO, Yuya KASAHARA, Atsushi MIKAMI
  • 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME
    Publication number: 20220127300
    Abstract: Disclosed are a 5?-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5?-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5?-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.
    Type: Application
    Filed: February 10, 2020
    Publication date: April 28, 2022
    Inventors: Satoshi OBIKA, Takao YAMAGUCHI, Takaki HABUCHI, Go KATO, Takao INOUE, Tokuyuki YOSHIDA, Md Ariful ISLAM
  • Antisense oligonucleic acid
    Patent number: 11261440
    Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2?,4?-bridged nucleic acids, 2?,4?-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2?,4?-non-bridged nucleic acid residue(s) is/are modified.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 1, 2022
    Assignee: Osaka University
    Inventors: Satoshi Obika, Reiko Waki, Takao Inoue, Tokuyuki Yoshida, Kunihiko Morihiro, Yuya Kasahara, Atsushi Mikami
  • ANTISENSE OLIGONUCLEIC ACID
    Publication number: 20200056178
    Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2?,4?-bridged nucleic acids, 2?,4?-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2?,4?-non-bridged nucleic acid residue(s) is/are modified.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 20, 2020
    Applicant: Osaka University
    Inventors: Satoshi OBIKA, Reiko WAKI, Takao INOUE, Tokuyuki YOSHIDA, Kunihiko MORIHIRO, Yuya KASAHARA, Atsushi MIKAMI