Abstract: A method of imaging a subject, the method comprising the steps: administering a radiotracer to the subject such that the radiotracer enters the bloodstream of the subject; allowing the radiotracer to accumulate in a kidney of the subject; and imaging said kidney using positron emission tomography (PET); wherein the radiotracer comprises a protein labelled with a 6-[18F]fluoropyridin-3-ylcarboxy group. The disclosure also relates to radiotracers and compositions suitable for use in said method, as well as to processes, kits and cassettes for preparing said radiotracers.

Abstract: The invention is in the field of papermaking. It provides methods for improving the compressive strength of paper and board by improving the moisture resistance of paper and board. The invention also provides paper and board with an improved compressive strength as well as a composition for improving the compressive strength of paper and board. More in particular, the invention relates to a process for the manufacture of paper wherein the process comprises a wet phase and a dry phase, wherein an enzymatically oxidized lignin is added in the wet phase.

Abstract: An optical probe, instrument, and method for measuring a tissue sample. The optical probe comprises a needle having a needle tip formed to penetrate a tissue surface and an optical waveguide arranged to transmit light through the needle; and a probe housing for holding the needle and comprising at least one of an actuator or a sensor configured to receive or generate a depth signal to determine a depth position of the needle tip relative to the tissue surface.

Abstract: An optical probe, instrument, and method for measuring a tissue sample. The optical probe comprises a needle having a needle tip formed to penetrate a tissue surface and an optical waveguide arranged to transmit light through the needle; and a probe housing for holding the needle and comprising at least one of an actuator or a sensor configured to receive or generate a depth signal to determine a depth position of the needle tip relative to the tissue surface.

Abstract: Method and instrument for analysing a tissue sample. Localized concentrations of an analyte are measured at a plurality of spaced apart locations around a controlled depth. Spatial variance of the analyte is calculated based on the measured analyte concentrations. The procedure is repeated while varying the controlled depth to obtain the spatial variance as a function of depth. Tissue at a particular depth may be evaluated as tumour tissue when the spatial variance is below the threshold. For example, a section distance is calculated between the tissue surface and a depth where the measured spatial variance crosses a predetermined threshold variance. Feedback can be provided based on a comparison between a calculated section distance and a pre-set minimum section margin.

Abstract: Method and instrument for analysing a tissue sample. Localized concentrations of an analyte are measured at a plurality of spaced apart locations around a controlled depth. Spatial variance of the analyte is calculated based on the measured analyte concentrations. The procedure is repeated while varying the controlled depth to obtain the spatial variance as a function of depth. Tissue at a particular depth may be evaluated as tumour tissue when the spatial variance is below the threshold. For example, a section distance is calculated between the tissue surface and a depth where the measured spatial variance crosses a predetermined threshold variance. Feedback can be provided based on a comparison between a calculated section distance and a pre-set minimum section margin.

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.

Abstract: The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity.

Abstract: A watercraft has a hull with a first end and a second end and is equipped at its second end with a propulsion arrangement that includes at least three propulsion devices each provided with a propeller. A majority of the propulsion devices are rudder propeller devices, and the propeller of at least one of the propulsion devices is at a first distance from the second end of the hull and the propeller of at least another one of the propulsion devices is at a second distance, greater than the first distance, from the second end of the hull. In ice conditions the watercraft is operated with the second end ahead, so that at least one propeller at the first distance from the second end of the hull breaks ice and at least one propeller at the second distance from the second end of the hull moves disintegrated ice or ice chunks away from the ice build-up.

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3- fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.

Abstract: The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity.

Abstract: A method of providing a watercraft, especially an icebreaker or a cargo ship, tanker or similar transport vessel, with improved ice penetration characteristics and a watercraft manufactured according to the method, which watercraft has a hull (1) with a first end (2) and a second end (3) and which is equipped at said second end with a propulsion arrangement, which provides the main propulsive thrust of the watercraft, while the watercraft moves with either end ahead, and the steering of the watercraft, whereby said second end (3) of the watercraft is shaped and designed so that it, as such, has efficient ice penetration characteristics.

Abstract: The invention relates to a method for the production of pyruvic acid, in particular pyruvic acid that is 13C-enriched at the C1-atom, i.e. 13C1-pyruvic acid.

Abstract: The invention relates to a method for the production of pyruvic acid, in particular pyruvic acid that is 13C-enriched at the C1-atom, i.e. 13C1-pyruvic acid.

Abstract: A combined-hardware-and-software secure-platform interface to which operating systems and customized control programs interface within a computer system. The combined-hardware-and-software secure-platform interface employs a hardware platform that provides at least four privilege levels, non-privileged instructions, non-privileged registers, privileged instructions, privileged registers, and firmware interfaces. The combined-hardware-and-software secure-platform interface conceals all privileged instructions, privileged registers, and firmware interfaces and privileged registers from direct access by operating systems and custom control programs, providing to the operating systems and custom control programs the non-privileged instructions and non-privileged registers provided by the hardware platform as well as a set of callable software services.

Abstract: A combined-hardware-and-software secure-platform interface to which operating systems and customized control programs interface within a computer system. The combined-hardware-and-software secure-platform interface employs a hardware platform that provides at least four privilege levels, non-privileged instructions, non-privileged registers, privileged instructions, privileged registers, and firmware interfaces. The combined-hardware-and-software secure-platform interface conceals all privileged instructions, privileged registers, and firmware interfaces and privileged registers from direct access by operating systems and custom control programs, providing to the operating systems and custom control programs the non-privileged instructions and non-privileged registers provided by the hardware platform as well as a set of callable software services.

Abstract: A method for manufacturing a dried or semi-dried meat product, such as casingless sausage, especially such a sausage popularly known as "meat sticks," though not limited thereto. A pre-formed meat emulsion with a moisture content in excess of 30% by weight, and a fat content in the range from about 5% to 50% by weight, is formed into the desired cross sectional shape and then frozen; thereafter, the sausage is optionally smoked, but, whether smoked or not, it is then dried at temperatures in excess of about 40.degree. F until the moisture content is in the range from about 10% to 30% by weight.