Patents by Inventor Tom A. Pfeifer

Tom A. Pfeifer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insect expression vectors
    Patent number: 7135337
    Abstract: The invention provides insect shuttle vectors, and methods of using such vectors, for stably transforming disparate insect cell lines to express heterologous proteins. The invention provides a transformed insect cell selection system based on resistance to the bleomycin/phleomycin family of antibiotics, including the antibiotic Zeocin. Efficient promoters derived from baculovirus immediate early promoters are disclosed for use in directing expression of heterologous proteins, including selectable markers, in transformed insect cells of the invention. Transposon-based vectors are disclosed that provide inducible transposition to optimize heterologous protein expression and unobtrusive markers to facilitate selection of desired transformants.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: November 14, 2006
    Inventors: Tom A. Grigliatti, Tom A. Pfeifer, David A. Theilmann, Dwayne D. Hegedus
  • Insect expression vectors
    Publication number: 20020116723
    Abstract: The invention provides insect shuttle vectors, and methods of using such vectors, for stably transforming disparate insect cell lines to express heterologous proteins. The invention provides a transformed insect cell selection system based on resistance to the bleomycin/phleomycin family of antibiotics, including the antibiotic Zeocin. Efficient promoters derived from baculovirus immediate early promoters are disclosed for use in directing expression of heterologous proteins, including selectable markers, in transformed insect cells of the invention. Transposon-based vectors are disclosed that provide inducible transposition to optimize heterologous protein expression and unobtrusive markers to facilitate selection of desired transformants.
    Type: Application
    Filed: June 29, 2001
    Publication date: August 22, 2002
    Inventors: Tom A. Grigliatti, Tom A. Pfeifer, David A. Theilmann, Dwayne D. Hegedus