Patents by Inventor Tom Boone

Tom Boone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-18 variants and methods of use
    Patent number: 11850276
    Abstract: The present disclosure provides compositions and methods comprising stabilized IL-18 polypeptides for use in therapeutic and non-therapeutic applications. In some cases, the stabilized IL-18 proteins provide IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP. Also provide are methods of administration and methods for making active polypeptides.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: December 26, 2023
    Assignees: Simcha IL-18, Inc., Yale University
    Inventors: Aaron Ring, Tom Boone
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 9006408
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: April 14, 2015
    Assignee: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES
    Publication number: 20140287479
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 25, 2014
    Applicant: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 8703926
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: April 22, 2014
    Assignee: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 8168416
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: May 1, 2012
    Assignee: Amgen Inc.
    Inventors: Tom Boone, David Park Meininger, Margrit Schwarz, Bei Shan, Wenyan Shen, Mingyue Zhou
  • Pin tumbler key lock assembly
    Publication number: 20080314105
    Abstract: A headed pin for use in pin tumbler locks is provided with a release diameter cylindrical body having an enlarged diameter axially short head at one end, the reduced diameter body being received internally of a biasing spring which bottoms against an underside of the head, the spring extending beyond the end of the cylindrical body opposite the head, and the headed pin and spring being received in one or more of the pinholes as the upper pin in a pin tumbler lock.
    Type: Application
    Filed: June 20, 2007
    Publication date: December 25, 2008
    Inventors: Kermit Lawson, T. Michael Phillips, Tom Boone, Douglas G. Davis