Abstract: The present invention provides anti-LRP5/6 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for treating diseases and disorders associated with Wnt pathway signaling.

Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: A method of wireless communication by a user equipment (UE) supporting multiple subscriptions, includes camping on a first cell of a first radio access technology (RAT) with a first data subscription, and camping on a second cell of a second RAT with a second data subscription. The method also includes triggering a transition to the first cell of the first RAT for the second data subscription. The method further includes performing, with the first data subscription, activities on behalf of the second data subscription.

Abstract: There is provided a computer-implemented method for updating a search distribution of an evolutionary strategies optimizer using an optimizer neural network comprising one or more attention blocks. The method comprises receiving a plurality of candidate solutions, one or more parameters defining the search distribution that the plurality of candidate solutions are sampled from, and fitness score data indicating a fitness of each respective candidate solution of the plurality of candidate solutions. The method further comprises processing, by the one or more attention neural network blocks, the fitness score data using an attention mechanism to generate respective recombination weights corresponding to each respective candidate solution. The method further comprises updating the one or more parameters defining the search distribution based upon the recombination weights applied to the plurality of candidate solutions.

Abstract: A system and method which compensates for phase mixer circuit non-linearities within a clock and data recovery (CDR) system during active operation. The CDR system includes compensation circuitry and phase accumulation circuitry. The compensation circuitry generates a first compensation signal based on a first compensation value. The phase accumulation circuitry receives the first compensation signal and a phase accumulator input update signal. The phase accumulation circuitry combines the first compensation signal with the phase accumulator input update signal to compensate for a first non-linearity within phase mixer (PMI) circuitry.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may determine, via a first subscription of the UE, a trigger event for a conditional handover of the UE from a source network entity to a target network entity. The UE may determine, based at least in part on the trigger event, that a target band associated with the target network entity is not compatible with a serving band associated with a second subscription of the UE. The UE may store the trigger event for the conditional handover in a buffer of the UE. The UE may perform an action related to the conditional handover based at least in part on a condition being satisfied. Numerous other aspects are described.

Abstract: Future data connection quality may be predicted based on historical data connection quality, and future requests for data may be predicted based on past requests. These predictions may be used to help decide whether, when, and/or how to deliver the data in a proactive manner. For example, according to some aspects described herein, a future data connection quality may be predicted based at least on historical data connection quality. It may be determined whether to pre-deliver at least a portion of an item of content based at least on the predicted future data connection quality. The pre-delivered portion may include any portion of the content including a latter portion of the content. If so, then the at least the portion of the item of content may be pre-delivered to the device and/or to another destination.

Abstract: Provided herein are anti-EGFRvII antibodies and binding fragments thereof. The anti-EGFRvIII antibodies of the disclosure are useful for the treatment of cancers through, e.g., antibody-dependent cell cytotoxicity (ADCC). Also provided herein are methods of making and using the anti-EGFRvIII antibodies for the treatment of cancer, and polynucleotides that encode the same.

Abstract: A head-mounted display (HMD) determines whether a set of criteria is satisfied based on eye-related readings collected by a camera of the HMD and wirelessly transmits a set of messages in response to a determination that the set of criteria is satisfied. An attachment includes a set of light-emitting diodes (LEDs) and activates the set of LEDs to emit the light at the bleaching intensity in response to receiving the set of messages.

Abstract: Methods and apparatus for providing delivery of content to client devices of a network via both multicast and unicast mechanisms. In one embodiment, a system for use in a managed content delivery network is described to bridge multicast to unicast, so that the total network bandwidth consumption is significantly lower than a corresponding unicast-only delivery solution, yet which still provides improved quality of service and user viewing experience as compared to a multicast-only delivery solution. In addition, various exemplary aspects of the present disclosure are readily adapted for real-time multicast to unicast streaming of audio and data to, among other things, minimize network bandwidth usage, while maintaining the guaranteed delivery of unicast streams with little or no modification to the existing client device logic.

Abstract: An avatar carrier generating system for metaverse and method thereof are disclosed. Before a living body enters a metaverse, a sensing element senses the living body to generate a physiological feature, and after a real-name identity message is received, the real-name identity message and the physiological feature are converted into metadata compliant with a non-fungible token standard; the non-fungible token, which is owned by the living body, is generated on the blockchain based on the metadata. When the living body enters the metaverse, an avatar carrier for entering the metaverse is generated based on the metadata of the non-fungible token, and when the avatar carrier receives an identification request, the avatar carrier is permitted to provide at least one of the physiological feature and the real-name identity message, so as to achieve the effect of improving identifiability and authentication of the avatar carrier of the metaverse.

Abstract: Aspects directed towards Quality of Service (QoS) flow remapping are disclosed. In an example, upon detecting a mapping reconfiguration of a first QoS flow from a first data radio bearer (DRB) to another DRB, a Service Data Adaptation Protocol (SDAP) control protocol data unit (PDU) is generated indicating that a final SDAP data PDU associated with the first QoS flow has been transmitted on the first DRB. The SDAP control PDU is then transmitted via the first DRB. In another example, upon detecting a mapping reconfiguration of a first QoS flow from a first DRB to another DRB, an end marker parameter is set in an SDAP header of a first SDAP data PDU received from an upper layer after the mapping reconfiguration indicating that the first SDAP data PDU is a final SDAP data PDU associated with the first QoS flow transmitted on the first DRB.

Abstract: System and method for enabling capturing of multiple images from a display device in which one or more image capturing devices disposed, at least partially, in the display device are controllably oriented to capture one or more views of a subject for combining (e.g., via optical tiling of captured image data) into a composite view.

Abstract: System and method for enabling capturing of multiple images from a display device in which one or more image capturing devices disposed, at least partially, in the display device are controllably oriented to capture one or more views of a subject for combining (e.g., via optical tiling of captured image data) into a composite view.

Abstract: System and method for enabling capturing of multiple images from a display device in which multiple image capturing devices disposed, at least partially, in the display device are controllably oriented to capture opposing offset views of a subject for combining (e.g., via optical tiling of captured image data) into a composite view.

Abstract: System and method for enabling capturing of multiple images from a display device in which multiple image capturing devices disposed, at least partially, in the display device are controllably oriented to capture opposing offset views of a subject for combining (e.g., via optical tiling of captured image data) into a composite view.

Abstract: A friction reducing treatment solution that includes water, from 100 to 500,000 ppm of total dissolved solids, and from 0.5 to 3 gallons per thousand gallons of a water-in-oil emulsion containing a water soluble polymer. The total dissolved solids include at least 10 weight percent of a multivalent cation. The water-in-oil emulsion includes an oil phase and an aqueous phase, where the oil phase is a continuous phase containing an inert hydrophobic liquid and the aqueous phase is present as dispersed distinct particles in the oil phase and contains water, the water soluble polymer, and surfactants and an inverting surfactant. The water soluble polymer is made up of 20 to 80 weight percent of a non-ionic monomer, 0.5 to 30 weight percent of a carboxylic acid containing monomer, and 5 to 70 weight percent of a cationic monomer and makes up from 10 to 35 weight percent of the water-in-oil emulsion.

Abstract: A aqueous solution that includes water, from 100,000 to 300,000 ppm of dissolved solids, from 0.5 to 3 gallons per thousand gallons of a water-in-oil emulsion, and an inverting surfactant. The water-in oil emulsion includes an oil phase and an aqueous phase where the oil phase is a continuous phase comprising an inert hydrophobic liquid and the aqueous phase is present as dispersed distinct particles in the oil phase. The aqueous phase contains water, a water soluble polymer, and surfactants. The water soluble polymer includes 30 to 50 weight percent of a non-ionic monomer, 5 to 15 weight percent of a sulfonic acid containing monomer, and 40 to 60 weight percent of a cationic monomer. The water soluble polymer makes up from 10 to 35 weight percent of the water-in-oil emulsion.

Abstract: Ampholyte polymeric compound that comprises at least one nonionic monomer, at least one sulfonic acid-containing monomer, and at least one cationic monomer may be useful in viscosifying treatment fluids for use in subterranean operations at a concentration of about 0.5 v/v % to about 30 v/v % of the treatment fluid. Such operations may involve introducing the treatment fluid into a wellbore penetrating a subterranean formation optionally at a pressure sufficient to create or extend at least one fracture in the subterranean formation.