Patents by Inventor Tom Chih-Chuang HU

Tom Chih-Chuang HU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for measuring and modeling in vivo manganese ion transport in a subject
    Patent number: 8738114
    Abstract: Described herein are systems and methods for quantitatively measuring manganese ion efflux in a subject. In general, the systems and methods compare imaging data from a subject taken over specific periods of time to pharmacokinetic models in order to measure manganese ion efflux rates from an organ in a subject. By understanding the specific location and rate of manganese ion efflux and influx from the organ, it is possible to more accurately correlate calcium ion activity. Calcium ion efflux is associated with a number of biological mechanisms in the subject, and the methods and systems described herein can be used as a diagnostic tool not only for monitoring calcium efflux in the subject but also aid in the treatment of diseases associated with changes in calcium ion efflux.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: May 27, 2014
    Assignee: Celtrast LLC
    Inventors: Tom Chih-Chuang Hu, Benjamin J. Waghorn, Nathan E. Yanasak
  • System and method for indirectly measuring calcium ion efflux
    Patent number: 8728439
    Abstract: A system and method for indirectly measuring calcium ion efflux from a cell of a subject by using manganese ions as a surrogate marker for calcium is disclosed. Manganese ion efflux is measured with a MEMRI T1-mapping method while the calcium-sodium exchanger is inhibited.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: May 20, 2014
    Assignee: Celtrast LLC
    Inventors: Tom Chih-Chuang Hu, Benjamin J. Waghorn
  • Systems And Methods For Measuring And Modeling In Vivo Manganese Ion Transport In A Subject
    Publication number: 20120123247
    Abstract: Described herein are systems and methods for quantitatively measuring manganese ion efflux in a subject. In general, the systems and methods compare imaging data from a subject taken over specific periods of time to pharmacokinetic models in order to measure manganese ion efflux rates from an organ in a subject. By understanding the specific location and rate of manganese ion efflux and influx from the organ, it is possible to more accurately correlate calcium ion activity. Calcium ion efflux is associated with a number of biological mechanisms in the subject, and the methods and systems described herein can be used as a diagnostic tool not only for monitoring calcium efflux in the subject but also aid in the treatment of diseases associated with changes in calcium ion efflux.
    Type: Application
    Filed: February 9, 2010
    Publication date: May 17, 2012
    Applicant: Cel-Trast, LLC
    Inventors: Tom Chih-Chuang Hu, Benjamin J. Waghom, Nathan E. Yanasak
  • SYSTEM AND METHOD FOR INDIRECTLY MEASURING CALCIUM ION EFFLUX
    Publication number: 20090246144
    Abstract: A system and method for indirectly measuring calcium ion efflux from a cell of a subject by using manganese ions as a surrogate marker for calcium is disclosed. Manganese ion efflux is measured with a MEMRI T1-mapping method while the calcium-sodium exchanger is inhibited.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 1, 2009
    Applicant: CELTRAST LLC
    Inventors: Tom Chih-Chuang HU, Benjamin J. WAGHORN