Abstract: A strain sensor utilizes an ohmic-based contact switch to detect strain. The sensor can be incorporated into other structures, such as an artificial flapping wing, to detect strain and other parameters, including air flow disturbances. The sensors are fabricated using an additive manufacturing process, with a layer of gold or other conductive material applied for electrical conductivity and UV laser ablation for electrical isolation. The sensor design incorporates mechanical amplification, converting small strains into larger displacements that close contact pads, resulting in an ohmic switch activated at a specific strain threshold. Unlike traditional sensors, the switch provides a high or low state output directly without the need for additional amplification or post-processing. The device can detect disturbances in flapping wing cycles and obtain yaw rotation information, with potential applications in other aircraft for disturbance detection.

Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Abstract: An adhesive label is provided. The adhesive label includes an adhesive patch that covers at least 50% but less than 85% of a backside surface of the adhesive label and that is at least partially horizontally and vertically centered on the backside surface.

Abstract: The invention provides a method of producing an alcohol-free beer, said method comprising: providing a vessel containing wort; inoculating the wort with yeast and allowing the yeast to form a settled layer on the bottom of the vessel or a floating layer below the surface of the wort; fermenting the inoculated wort at a temperature of ?3 to 5° C. for a period of at least 8 hours to produce a fermented wort; separating the fermented wort from the yeast to produce alcohol-free beer; wherein: one or more pitchings of additional yeast into the inoculated wort are applied during the fermentation; or one or more disruptions of the layer of yeast are applied during the fermentation; or at the beginning of the fermentation the wort is inoculated with at least 3×106 yeast cells per mL of wort. The present method offers the advantage that it yields an alcohol-free beer in which undesirable ‘worty’ flavour notes are substantially reduced.

Abstract: A suspension system including hydraulic circuits that extend between dampers located at opposite corners of the vehicle and at least one load distribution unit that is connected in fluid communication with at least two hydraulic circuits. The load distribution unit includes a manifold block with a cylinder bore, a pair of pressure tubes, a piston rod assembly, and a pair of reserve tubes. The pressure tubes are partially received in the cylinder bore to define a pair of opposed cylinders. The piston rod assembly includes a piston rod and a pair of opposed pistons that are slidingly received within the opposed cylinders. The reserve tubes are at least partially received in the cylinder bore and are arranged annularly about the pressure tubes to define a first pair of reservoir chambers between the pressure tubes and the reserve tubes.

Abstract: A suspension system including hydraulic circuits that extend between dampers located at opposite corners of the vehicle and at least one load distribution unit that is connected in fluid communication with at least two hydraulic circuits. The load distribution unit includes a manifold block with a cylinder bore, a pair of pressure tubes, a piston rod assembly, and an integral rod guide and pressure tube coupler. The pressure tubes are partially received in the cylinder bore to define a pair of opposed cylinders and mate with the integral rod guide and pressure tube coupler. The piston rod assembly includes a piston rod and a pair of opposed pistons that are slidingly received within the opposed cylinders. In addition to retaining the pressure tubes, the integral rod guide and pressure tube coupler supports and permits the piston rod to slide longitudinally relative to the manifold block.

Abstract: Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein provide barrier and prevent the migration of a bioactive agent from the wound. Thus, the tissue grafts enhance wound healing while preventing the undesirable migration of a bioactive agent from the wound. Methods for making and using the cross-linked grafts are also described herein.

Abstract: An outdoor unit for a heat pump includes a refrigerant circuit, the outdoor unit including a compressor, a discharge pipe of the refrigerant circuit connected to a discharge side of the compressor, a bottom plate, the bottom plate having a base and an outer flange protruding upward from an outer edge of the base, a heat source heat exchanger supported on the bottom plate, a liquid refrigerant pipe of the refrigerant circuit connected to the heat source heat exchanger, and a defrosting bypass pipe connected at one end to the discharge pipe and at the opposite end to the liquid refrigerant pipe, the defrosting bypass pipe being arranged between an inner side of the flange and an outer side of the heat source heat exchanger.

Abstract: A method of assembling an accumulator for a suspension damper where the method includes the steps of forming an outer shell of an accumulator, assembling a bellows assembly by connecting distal and proximal plates to opposite ends of an annular bellows wall, and inserting the bellows assembly into the outer shell. The outer shell is formed such that it includes a distal end with an end wall and an open end opposite the distal end. The bellows assembly is inserted into the open end of the outer shell with the distal plate facing the end wall of the outer shell. The method proceeds with coupling the distal plate of the bellows assembly to a stem of a gas charging port on the end wall of the outer shell at a fixed axial position using a fixation component that engages the stem of the gas charging port.

Abstract: An accumulator for a vehicle suspension damper, which includes an outer shell with an open end that connects to an accumulator port on the damper and a distal end, opposite the open end, which includes an end wall that extends radially inward to a gas charging port. A bellows assembly, which includes an annular bellows wall extending between proximal and distal plates, is positioned inside the outer shell to define a pressurized gas chamber inside the accumulator that is arranged in fluid communication with the gas charging port. The gas charging port includes a stem that extends inwardly from the end wall of the outer shell and the distal plate of the bellows assembly has an inner diameter that is received on the stem. The inner diameter of the distal plate is coupled to the stem of the gas charging port by a fixation component.

Abstract: The invention relates to a method of preparing a beer having an ethanol content of 0-3.0% ABV, in situ fermentative production of gluconate component selected from gluconic acid, gluconate, glucono delta-lactone and combinations thereof by: (a) subjecting the boiled wort to two successive fermentation steps, starting with a fermentation step that generates the gluconate component, followed by the yeast fermentation; or (b) subjecting a first boiled wort to yeast fermentation to produce the yeast fermented wort; subjecting a second boiled wort to another fermentation step to generate the gluconate component and to produce a second fermented wort; and combining the yeast fermented wort and the second fermented wort. Also disclosed is a beer having an ethanol content of 0-3.0% ABV, and produced by the method.

Abstract: The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.

Abstract: The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.

Abstract: The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.

Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK.

Abstract: An electronic device includes a processor, a memory, an embedded element storing information, and a short-range radio controller. The embedded element is readable by an external reader. The short-range radio controller is configured to receive a radio communication. If the short-range radio controller is being powered by a primary battery that powers the processor, the short-range radio controller is configured to route the radio communication to the embedded element if the radio communication is for accessing the embedded element, or route the radio communication to a component of the electronic device different from the embedded element if the radio communication is not for accessing the embedded element. If the short-range radio controller is not being powered by the primary battery, the short-range radio controller is configured to route the radio communication to the embedded element.

Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK.

Abstract: The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.

Abstract: The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.

Abstract: A device for and method to provide pet rewards. The device includes a sound apparatus to alert a pet that a reward is about to be dispensed and a video camera wirelessly coupled to a remote user device to view the pet and the dispensing of a reward. Remote control of sounds, treat delivery, and pet viewing over a wireless connection can be provided with and through a user device. The method include connecting to a wireless network, a remote use device connection to the device, and the user device sending commands for sending video data, outputting sounds, and dispensing pet-rewards.