Abstract: A medical device system configured to occlude an opening in a heart, the medical device system including a delivery system and an implant. The delivery system including a handle and a catheter, the implant removably coupled to the catheter. The implant includes a frame work and a tissue growth member. The tissue growth member includes an inner sheet, an outer sheet, and a reinforcement textile. The inner sheet is positioned along an inner side of the framework and the outer sheet is positioned along an outer side of the framework. The reinforcement textile is positioned between the inner and outer sheets to define a texture along an outer surface of the tissue growth member.

Abstract: A medical device configured to be percutaneously delivered to a heart with a catheter of a medical device delivery system. The medical device including a framework and tissue growth member. The framework includes a hub with frame segments extending radially from the hub. The tissue growth member is attached to the framework and extends radially along the framework such that the tissue growth member extends to define an outer layer portion and an inner layer portion where the framework is coupled to the inner layer portion. Further, the tissue growth member extends with multiple voids defined therein such that a filler material is configured to temporarily fill the multiple voids of the tissue growth member.

Abstract: A durability testing fixture, system and method for testing a medical device. The testing fixture include a stabilizing member, an inflatable member and a pressure controller. The inflatable member is positioned adjacent the stabilizing member and defines a bore therein, the bore sized to hold the medical device. The inflatable member is configured to receive and release a fluid so that the inflatable member is respectively inflatable and deflatable to radially displace an inner surface of the bore. The pressure controller is coupled to the inflatable member and is configured to control inflation and deflation of the inflatable member to radially displace the inner surface of the bore and to apply a force directly along an outer radially extending surface of the medical device.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart are provided. In one embodiment, the medical device includes an occluder portion and an anchor portion that are pivotably coupled to each other with hinge components. The hinge components each include a base with arms extending from the base such that the arms of each one of the hinge components extend through and capture a first eyelet of the occluder portion and a second eyelet of the anchor portion to facilitate pivotably coupling the anchor portion to the occluder portion.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart are provided. In one embodiment, the medical device includes an occluder portion and an anchor portion that are pivotably coupled to each other with hinge components. The hinge components each include a base with arms extending from the base such that the arms of each one of the hinge components extend through and capture a first eyelet of the occluder portion and a second eyelet of the anchor portion to facilitate pivotably coupling the anchor portion to the occluder portion.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart with an implantable medical device and three-dimensional imaging. In one embodiment, the imaging is facilitated with a controller coupled to one or more magnetic field generators and a display, the one or more magnetic field generators configured to generate a magnetic field within the anatomy of a patient and the display provides the imaging and display information thereon. The medical system also includes a medical device delivery system for delivering the implantable medical device. The medical device includes one or more magnetic field location sensors therewith that are operatively coupled to the controller. With this arrangement, the sensors are sized and configured to facilitate providing the three-dimensional imaging within the heart that is viewable on the display to assist a physician to safely and effectively implant the medical device.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart with an implant are provided. In one embodiment, a medical device system includes a sheath for delivering the implant. The sheath includes, at a distal portion of the sheath, first and second deflectable portions that are each independently deflectable relative to first and second pivot locations, respectively. With this arrangement, at least one of the first and second pivot locations are adjustable along a longitudinal length of the distal portion of the sheath.

Abstract: Medical devices, systems and methods for forming an occlusive material for occluding a left atrial appendage of a heart are provided. In one embodiment, the occlusive material includes a foam portion that extends as a single piece, seamless monolithic structure that is sized to couple to an external side of a framework of a medical device. In another embodiment, the occlusive material may include a polymeric laminate. Such polymeric laminate may be adhered to an outer side of the foam portion. Further, various embodiments for forming a polymer laminate are provided.

Abstract: Medical devices, systems and methods for occluding a left atrial appendage of a heart are provided. In one embodiment, the medical device includes an occluder portion and an anchor portion that are pivotably coupled to each other with hinge components. The hinge components each include a base with arms extending from the base such that the arms of each one of the hinge components extend through and capture a first eyelet of the occluder portion and a second eyelet of the anchor portion to facilitate pivotably coupling the anchor portion to the occluder portion.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A catheter includes an elongated body, a distal assembly with a shape-memory member defining a generally helical form, and a control handle. The control handle may be adapted to actuate a deflection puller wire for deflecting a portion of the elongated body and a contraction wire for contracting the generally helical form. The generally helical form carries irrigated ablation ring electrodes. A nitinol support member with shape memory extends through the distal assembly and into the elongated body to provide the helical form. The support member may have a varying stiffness along its length, for example, a decreasing stiffness toward a distal end of the support member. The support member can also be hollow so that it can receive a mandrel whose stiffness is greater than that of the support member.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

Abstract: A catheter includes an elongated body, a distal assembly with a shape-memory member defining a generally helical form, and a control handle. The control handle may be adapted to actuate a deflection puller wire for deflecting a portion of the elongated body and a contraction wire for contracting the generally helical form. The generally helical form carries irrigated ablation ring electrodes. A nitinol support member with shape memory extends through the distal assembly and into the elongated body to provide the helical form. The support member may have a varying stiffness along its length, for example, a decreasing stiffness toward a distal end of the support member. The support member can also be hollow so that it can receive a mandrel whose stiffness is greater than that of the support member.

Abstract: An apparatus for deployment and retrieval of a self-expanding intravascular stent includes an intravascular delivery wire and one or more rings of compliant material fixedly mounted over at least a portion of the intravascular delivery wire. The distal portion of the intravascular delivery wire can be stepped, having a smaller diameter than the proximal portion, and forming a hard stop. Distal and proximal bands can also be provided on the intravascular delivery wire to form hard stops. A self-expanding intravascular stent can releasably retained on the compliant material.

Abstract: Embodiments of the present invention generally provide an anastomosis device that can be used to couple two or more layers of tissue in apposition. In an exemplary embodiment, the device can be formed from one or more woven wires that can be configured to have a generally tubular shape in a first, expanded position for insertion to an anastomosis site and a generally annular, ring-shape in a second, resting position for securing tissue in apposition at the anastomosis site. The device can be adapted either to cause necrosis of the tissue layers around an outer periphery of the device or to promote growth of tissue about an inner periphery of the device.