Patents by Inventor Tom Dziubla

Tom Dziubla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antioxidant polymer nanocarriers for use in preventing oxidative injury
    Patent number: 7597907
    Abstract: The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: October 6, 2009
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Tom Dziubla
  • Antioxidant polymer nanocarriers for use in preventing oxidative injury
    Publication number: 20060127386
    Abstract: The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.
    Type: Application
    Filed: November 4, 2005
    Publication date: June 15, 2006
    Inventors: Vladimir Muzykantov, Tom Dziubla