Patents by Inventor Tom Ellenberger

Tom Ellenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20220202821
    Abstract: The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 30, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of The University of Arkansas, Washington University
    Inventors: John A. TAINER, Zamal AHMED, Darin E. JONES, In-Kwon KIM, Tom ELLENBERGER, Chris HO
  • CRYSTAL OF XPA AND ERCC1 COMPLEX AND USES THEREOF
    Publication number: 20100331233
    Abstract: The present invention relates to complexes and crystals of an XPA peptide and an ERCC1 peptide, and structural coordinates of the complex obtained from such crystals. The coordinates are useful for identifying compounds that bind to ERCC1 and inhibit binding of XPA, and thus inhibitors of nucleotide excision repair (NER). The NER inhibitors are used for treating neoplastic diseases, cancer, and hyperproliferative disorders.
    Type: Application
    Filed: October 4, 2008
    Publication date: December 30, 2010
    Inventors: Orlando D. Schärer, Tom Ellenberger, Oleg V. Tsodikov