Abstract: An implantable lead for sensing mechanical activity of a human heart has an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electrical conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at the distal end thereof. The polymeric tube is provided with a conductive surface layer along the inner face between the polymeric tube and the electrical conductor, the conductive surface layer being in electrical contact with this conductor. Accumulation of electrical charges between the electric conductor and the polymeric tube is thereby prevented.

Abstract: A medical implant device or component thereof comprising a metal substrate and a coating layer structure provided on the substrate. The coating layer structure comprises an outermost layer of a ceramic material. A bonding structure is deposited between the metal substrate and the coating layer structure. The bonding structure comprises a chromium rich layer, which is deposited onto the metal substrate surface and has a higher concentration of chromium than the metal substrate, as well as a gradient layer having a composition gradient from the chromium rich layer towards the surface of the device providing increasing proportions of a gradient material which has structural correspondence with the layer of the coating layer structure that is most adjacent to the bonding structure.

Abstract: In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: A medical implant device or component thereof comprising a metal substrate and a coating layer structure provided on the substrate. The coating layer structure comprises an outermost layer of a ceramic material. A bonding structure is deposited between the metal substrate and the coating layer structure. The bonding structure comprises a chromium rich layer, which is deposited onto the metal substrate surface and has a higher concentration of chromium than the metal substrate, as well as a gradient layer having a composition gradient from the chromium rich layer towards the surface of the device providing increasing proportions of a gradient material which has structural correspondence with the layer of the coating layer structure that is most adjacent to the bonding structure.

Abstract: An analyte measuring system includes implantable medical device having a RF signal source arranged for generating a RF signal and a transmitting antenna for transmitting the RF signal into a surrounding tissue in a subject body. The system has a receiving RF antenna for receiving the RF signal from the tissue and a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectral analysis of the received RF signal.

Abstract: In a method and apparatus for determining the replacement time of an electric battery in an implantable medical device, the battery being a hybrid battery with a combination of at least two electrode materials, one of which having better properties for high current pulsing and the other of which being a high energy density material, an electrical pulse of a predetermined duration and predetermined amplitude is drawn from the battery. The pulse amplitude significantly exceeds a base current drawn from the battery. The difference between voltages measured across the battery terminals before the pulse is emitted and at an end of the pulse is determined. The battery replacement time is determined from the voltage difference according to a predetermined criterion.

Abstract: In a device and method for a medical implant for monitoring progression of heart failure in a human heart, an activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.

Abstract: A method for making a metal-vanadium oxide product includes selecting a metal, the group Au, Ag, Cu and Pt, providing nanotubular vanadium oxide composed of vanadium oxide layers separated by templating molecules, and producing a product by ionic change of the nanotubular vanadium oxide with a solution of the salt of the metal. The salt is selected from the group AuCl3, Au(CN)3, AgNO3, AgC2H3O2, HgClO3, AgF, PtCl4, Ptl4, and H2PtCl6. The selected metal can be in the form of nanometer-sized particles.

Abstract: In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.

Abstract: A method for producing a biocompatible material of the formula NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0?x?0.8, 0.2?y?1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

Abstract: An implantable lead for sensing mechanical activity of a human heart has an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electrical conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at the distal end thereof. The polymeric tube is provided with a conductive surface layer along the inner face between the polymeric tube and the electrical conductor, the conductive surface layer being in electrical contact with this conductor. Accumulation of electrical charges between the electric conductor and the polymeric tube is thereby prevented.

Abstract: In a method for fixing tubing of a cardiac lead to a termination element, such as an electrode or a pin connector and in a cardiac lead formed according to such a method, an exterior of the termination element is provided with a thermoplastic fixation element, and thermoplastic tubing is provided with an end portion that coaxially surrounds a portion of the fixation element. A section of the end portion of the thermoplastic tubing is fused to the thermoplastic fixation element, so that the thermoplastic tubing is fixed to the termination element.

Abstract: Metal-vanadium-oxide-product where the metal is Au, Ag or Pt and where the product is obtained by ion exchange of nanotubular vanadium oxide comprising vanadium oxide layers separated by templating molecules with a solution of a salt of the metal. Use of the metal-vanadium-oxide-product according to the invention as active cathode material in a battery. A process of producing of the metal-vanadium-oxide-product according to the invention. An active cathode material comprising a metal-vanadium-oxide-product according to the invention. A lithium battery comprising at least one lithium anode, at least one vanadium oxide cathode, an electrolyte and an adhesive layer bonding each of the anodes and the cathodes to the electrolyte, where the vanadium oxide cathode comprises a metal-vanadium-oxide-product according to the invention.

Abstract: In a method and apparatus for determining the replacement time of an electric battery in an implantable medical device, the battery being a hybrid battery with a combination of at least two electrode materials, one of which having better properties for high current pulsing and the other of which being a high energy density material, an electrical pulse of a predetermined duration and predetermined amplitude is drawn from the battery. The pulse amplitude significantly exceeds a base current drawn from the battery. The difference between voltages measured across the battery terminals before the pulse is emitted and at an end of the pulse is determined. The battery replacement time is determined from the voltage difference according to a predetermined criterion.