Patents by Inventor Tom G. DRIVER

Tom G. DRIVER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nicotinamide phosphoribosyltransferase inhibitors and methods for use of the same
    Patent number: 12030901
    Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: July 9, 2024
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, The Board of Trustees of the University of Illinois
    Inventors: Tom G. Driver, Roberto F. Machado, Naijing Su, Xinyu Guan, Wrickban Mazumdar, Kira Ratia, Jason Ralph Hickok, Angelia Denise Lockett
  • COMPOUNDS FOR INCREASING THE NICOTINAMIDE ADENINE DINUCLEOTIDE IN A SUBJECT AND METHODS OF USE THEREOF
    Publication number: 20230365521
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that increase the amount of nicotinamide adenine dinucleotide (NAD+) in a subject. By raising the amount of nicotinamide adenine dinucleotide in a subject, diseases associated with reduced levels of nicotinamide adenine dinucleotide can be treated or prevented. In one aspect, raising the amount of NAD+ in a subject can reduce or ameliorate one or more symptoms of Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, amylotrophic lateral sclerosis, AIDS-induced dementia, or epilepsy.
    Type: Application
    Filed: April 21, 2023
    Publication date: November 16, 2023
    Inventors: Jesse GORDON-BLAKE, Tom G. DRIVER, Kiira RATIA, Gregory R. THATCHER, Victoria WEIDIG, Leon TAI
  • NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME
    Publication number: 20230124268
    Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Application
    Filed: November 16, 2022
    Publication date: April 20, 2023
    Inventors: Tom G. DRIVER, Roberto F. MACHADO, Najing SU, Xinyu GUAN, Wrickban MAZUMDAR, Kira RATIA, Jason Ralph HICKOK, Angelia Denise LOCKETT
  • Nicotinamide phosphoribosyltransferase inhibitors and methods for use of the same
    Patent number: 11584766
    Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: February 21, 2023
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Tom G. Driver, Roberto F. Machado, Najing Su, Xinyu Guan, Wrickban Mazumdar, Kira Ratia, Jason Ralph Hickok, Angelia Denise Lockett
  • NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME
    Publication number: 20210070784
    Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Application
    Filed: February 5, 2019
    Publication date: March 11, 2021
    Inventors: Tom G. DRIVER, Roberto F. MACHADO, Najing SU, Xinyu GUAN, Wrickban MAZUMDAR, Kira RATIA, Jason Ralph HICKOK, Angelia Denise LOCKETT