Patents by Inventor Tom G. Holt

Tom G. Holt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of achieving antitumor activity using 16-membered-macrolide-type compounds
    Patent number: 5324720
    Abstract: Inhibition of renal cancer, melanoma, colon cancer, lung cancer and leukemia cells by administration of compounds from the bafilomycin and hygrolidin groups of compounds.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: June 28, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Tom G. Holt, Richard L. Monaghan
  • Methods of achieving antileukemia activity using 16-membered-macrolide-type compounds
    Patent number: 5306716
    Abstract: Inhibition of renal cancer, melanoma, colon cancer, lung cancer and leukemia cells by administration of compounds from the bafilomycin and hygrolidin groups of compounds.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: April 26, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Tom G. Holt, Richard L. Monaghan
  • Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
    Patent number: 5256663
    Abstract: The present invention relates to pharmaceutical compositions comprising matter extracted from the well-known and readily available tropical marine invertebrate, Ecteinascidia turbinata, and designated herein as ecteinascidins, and to the use of such compositions as antibacterial, anti-viral, and/or antitumor agents in mammals.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: October 26, 1993
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth Rinehart, Sakai Ryuichi, Tom G. Holt
  • Ecteinascidins 729, 743, 745, 759A, 759B and 770
    Patent number: 5089273
    Abstract: The present invention relates to novel compositions of matter extracted from the well-known and readily available tropical marine invertebrate, Ecteinascidia turbinata, and designated herein as ecteinascidins 729, 743, 745, 759A, 759B and 770. These compounds are useful as antibacterial and/or antitumor agents in mammals.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: February 18, 1992
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Kenneth L. Rinehart, Tom G. Holt