Publication number: 20070093502
Abstract: The present invention concerns 5- or 6-substituted-benzimidazole derivatives having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein Q is Ar2, R6, pyrrolidinyl substituted with R6, piperidinyl substituted with R6 or homopiperidinyl substituted with R6, G is a direct bond or optionally substituted C1-10-alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle; one of R2a and R2b is cyanoC1-6alkyl, cyanoC2-6alkenyl, Ar3C1-6alkyl, Het-C1-6alkyl, N(R8aR8b)C1-6alkyl, Ar3C2-6alkenyl, Het-C2-6alkenyl, Ar3aminoC1-6alkyl, Het-aminoC1-6alkyl, Ar3thioC1-6alkyl, Het-thioC1-6alkyl, Ar3sulfonylC1-6alkyl, Het-sulfonylC1-6alkyl, Ar3aminocarbonyl, Het-aminocarbonyl, Ar3(CH2)naminocarbonyl, Het-(CH2)naminocarbonyl, Ar3carbonylamino, Het-carbonylamino, Ar3(CH2)ncarbonylamino, Het-(CH2)ncarbonylamino, and the other one of R2a and R2b is hydrogen; in case R
Type:
Application
Filed:
December 20, 2004
Publication date:
April 26, 2007
Inventors:
Jean-Francois Bonfanti, Koenraad Andries, Jerome Fortin, Philippe Muller, Frederic Doublet, Christophe Meyer, Rudy Willebrords, Tom Gevers, Philip Timmerman