Abstract: This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

Abstract: This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein j, k, m, Q, X, R1, R2a, R2b, R2c, R2d and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, N-oxide, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Abstract: A machine tool includes a table slidably supported on a carrier and movable relative to the carrier by a driving device, a telescopic covering device having two or more cover members telescopically slide relative to each other in response to a sliding movement between the table and the carrier. A connecting device includes a tubular member attached to the inner cover member, and a rod attached to the carrier and movable into and out of the tubular member when the inner cover member is moved relative to the carrier for guiding the table to smoothly slide relative to the carrier.

Abstract: A telescopic safety shield device includes a carrier movably engaged onto a platform and having one or more guideways tilted relative to the platform, a tool rest movably engaged onto the guideways and moveable inclinedly relative to the carrier and the platform, and a telescopic shielding device having two or more casing members coupled between the platform and the tool rest for shielding the area between the platform and the tool rest, the casing members are pivotally coupled to the platform and the tool rest for allowing the casing members to be pivoted relative to the platform and the tool rest respectively and for preventing dirt or contaminant from entering into the areas between the platform and the tool rest.

Abstract: A machine tool includes a table slidably supported on a carrier and movable relative to the carrier by a driving device, a telescopic covering device having two or more cover members telescopically slide relative to each other in response to a sliding movement between the table and the carrier. A connecting device includes a tubular member attached to the inner cover member, and a rod attached to the carrier and movable into and out of the tubular member when the inner cover member is moved relative to the carrier for guiding the table to smoothly slide relative to the carrier.

Abstract: A stop device for processing machine includes an engaging member mounted to a positioning device and has a tapered male mold which extends above the positioning device. A female mold is connected to an underside of the rotatable board and has a recess which is shaped to receive the male mold. A groove is defined in an underside of the female mold and is wide enough to stop cutting fluid from flowing along the female mold and entering the space between the recess of the female mold and the male mold.

Abstract: This invention is directed to oxindole compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.

Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.