Patents by Inventor Tom Isaac
Tom Isaac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230042115Abstract: A method of manipulating microdroplets having an average volume in the range 0.5 femtolitres to 10 nanolitres comprised of at least one biological component and a first aqueous medium having a water activity of aw1 of less than 1 is provided. It is characterised by the step of maintaining the microdroplets in a water-immiscible carrier fluid which further includes secondary droplets having an average volume less than 25% of the average volume of the microdroplets up to and including a maximum of 4 femtolitres and wherein the volume ratio of carrier fluid to total volume of microdroplets per unit volume of the total is greater than 2:1. The method may be employed for example with microdroplets containing biological cells or with microdroplets containing single nucleoside phosphate such as are prepared in a droplet-based nucleic acid sequencer.Type: ApplicationFiled: October 25, 2022Publication date: February 9, 2023Applicant: Lightcast Discovery LtdInventors: Tom ISAAC, Barnaby BALMFORTH, Jasmin CONTERIO, Kerr Francis JOHNSON, Maciej SOSNA, Richard INGHAM, Gareth PODD
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Patent number: 11504715Abstract: A method of manipulating microdroplets having an average volume in the range 0.5 femtolitres to 10 nanolitres comprised of at least one biological component and a first aqueous medium having a water activity of aw1 of less than 1 is provided. It is characterised by the step of maintaining the microdroplets in a water-immiscible carrier fluid which further includes secondary droplets having an average volume less than 25% of the average volume of the microdroplets up to and including a maximum of 4 femtolitres and wherein the volume ratio of carrier fluid to total volume of microdroplets per unit volume of the total is greater than 2:1. The method may be employed for example with microdroplets containing biological cells or with microdroplets containing single nucleoside phosphate such as are prepared in a droplet-based nucleic acid sequencer.Type: GrantFiled: February 7, 2020Date of Patent: November 22, 2022Assignee: LIGHTCAST DISCOVERY LTDInventors: Tom Isaac, Barnaby Balmforth, Jasmin Conterio, Kerr Francis Johnson, Maciej Sosna, Richard Ingham, Gareth Podd
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Publication number: 20220088606Abstract: A method of manipulating microdroplets having an average volume in the range 0.5 femtolitres to 10 nanolitres comprised of at least one biological component and a first aqueous medium having a water activity of aw1 of less than 1 is provided. It is characterised by the step of maintaining the microdroplets in a water-immiscible carrier fluid which further includes secondary droplets having an average volume less than 25% of the average volume of the microdroplets up to and including a maximum of 4 femtolitres and wherein the volume ratio of carrier fluid to total volume of microdroplets per unit volume of the total is greater than 2:1. The method may be employed for example with microdroplets containing biological cells or with microdroplets containing single nucleoside phosphate such as are prepared in a droplet-based nucleic acid sequencer.Type: ApplicationFiled: February 7, 2020Publication date: March 24, 2022Applicant: Lightcast Discovery LtdInventors: Tom ISAAC, Barnaby BALMFORTH, Jasmin CONTERIO, Kerr Francis JOHNSON, Maciej SOSNA, Richard INGHAM, Gareth PODD
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Publication number: 20220008927Abstract: Devices, systems, and associated methods are provided for manipulating and/or determining one or more characteristics of cells contained within a biological sample. In particular a device and methods of use thereof are provided, the device comprising a sorting component configured to separate cell-containing microdroplets from empty ones into a population of cell-containing first microdroplets; a microdroplet manipulation component configured to manipulate the first microdroplets using real or virtual electrowetting electrodes, and an optical detection system configured to detect an optical signal from the microdroplets via the one or more detection windows.Type: ApplicationFiled: November 8, 2019Publication date: January 13, 2022Applicant: LIGHTCAST DISCOVERY LTDInventors: Tom ISAAC, Cameron FRAYLING
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Patent number: 8709396Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: GrantFiled: February 18, 2008Date of Patent: April 29, 2014Assignee: Premark FEG L.L.C.Inventors: Joel Tenney, Tom Isaac, William Ernst
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Patent number: 7922992Abstract: The invention is a method and composition for producing carbon dioxide that is based on the reaction or activation of at least one carbon-containing compound with protons. The carbon-containing compound can be in the form of a powder, an impregnated carrier (e.g. zeolite crystals) or an aqueous solution and is preferably selected from the group consisting of carbonates, bicarbonates or sesquicarbonates. The protons are preferably provided by a proton-generating species such as an acid or metal salt. The method and composition can further include a water-retaining substance and/or a chlorine dioxide-producing compound in accordance with the invention.Type: GrantFiled: September 13, 2002Date of Patent: April 12, 2011Assignee: ICA Trinova, LLCInventors: William Ernst, Joel Tenney, Tom Isaac
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Publication number: 20080138372Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: ApplicationFiled: February 18, 2008Publication date: June 12, 2008Inventors: Joel TENNEY, Tom Isaac, William Ernst
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Patent number: 7347994Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: GrantFiled: September 12, 2003Date of Patent: March 25, 2008Assignee: ICA Trinova, LLCInventors: Joel Tenney, Tom Isaac, William Ernst
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Publication number: 20040126402Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: ApplicationFiled: September 12, 2003Publication date: July 1, 2004Applicant: ICA TriNova LLCInventors: Joel Tenney, Tom Isaac, William Ernst
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Publication number: 20040051080Abstract: The invention is a method and composition for producing carbon dioxide that is based on the reaction or activation of at least one carbon-containing compound with protons. The carbon-containing compound can be in the form of a powder, an impregnated carrier (e.g. zeolite crystals) or an aqueous solution and is preferably selected from the group consisting of carbonates, bicarbonates or sesquicarbonates. The protons are preferably provided by a proton-generating species such as an acid or metal salt. The method and composition can further include a water-retaining substance and/or a chlorine dioxide-producing compound in accordance with the invention.Type: ApplicationFiled: September 13, 2002Publication date: March 18, 2004Applicant: ICA TriNova, LLCInventors: William Ernst, Joel Tenney, Tom Isaac