Abstract: A datacenter power management system and method is disclosed. A plurality of computing units are enabled to operate at a second frequency, higher than a first frequency, in response to determining from respective power coefficients for these computing units, that a power level at this higher frequency remains below a power budget.

Abstract: In a wavelength selective switch, an input port transmits an input beam, and diffraction grating disperses the input beam into optical channels. A liquid-crystal-on-silicon (LCoS) switch assembly has a phase grating profile and has addressable pixels, which are liquid crystal based. The LCoS switch assembly can selectively direct first-order diffracted beams of the optical channels for output to selected output ports. A tunable optical wedge adjacent the LCoS switch assembly can direct higher-order diffraction beams in the space between the output ports to reduce crosstalk. The wedge is a liquid crystal cell having spaced-apart resistive layers and having liquid crystal material disposed between the layers. In the wedge, the liquid crystal material can produce a phase profile in response to bias voltages applied to the resistive layers, and a beam steering angle of the phase profile can direct at least the second-order diffracted beams towards the port spacing between the ports.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to OX40. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are functional agonists of OX40. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by OX40.

Abstract: A datacenter power management system and method is disclosed.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to OX40. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are functional agonists of OX40. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by OX40.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: A multiple wavelength selective switch has an optics assembly to receive a first input optical signal from a first ingress port and a second input optical signal from a second ingress port. A switch assembly has a single switching mechanism to direct the first input optical signal to the optics assembly as a first output optical signal and the second input optical signal to the optics assembly as a second output optical signal. The switch assembly directs the first output optical signal to a first egress port selected from the first set of egress ports and directs the second output optical signal to a second egress port selected from the second set egress ports. The first egress port and the second egress port have the same wavelength channel. The multiple wavelength selective switch supports an arbitrary number of wavelength channels that can be switched at the same time. Each switch assembly directs signals from a set of ingress ports to a set of egress ports sharing the same wavelength channel.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

Abstract: A dual-band input transceiver block is formed to operably receive one of a 2.4 GHz radio frequency signal or a 5.0 GHz radio frequency transceiver signal in a manner that minimizes duplication of circuitry and creates a combined circuit path for RF front end input stages for much of the input stage. More specifically, the embodiments of the present invention include separate amplification and mixing stages whose outputs are combined by a stabilized load with circuitry for removing a common mode feedback signal. As such, downstream components, such as amplifiers, filters, analog-to-digital converters, and other input path circuit elements, are not duplicated and may be used regardless of whether the dual-band transceiver is operating in a first or second frequency band. Operation is, in the described embodiment, only one frequency input at a time though the invention is not limited to such operation.

Abstract: According to an example embodiment, an apparatus is provided in a wireless transceiver. The apparatus may include a circuit configured to generate a first frequency signal (e.g., a VCO signal). A local oscillator (LO) generator may be provided that includes a frequency divider to divide the first frequency signal, and an image rejection mixer configured to mix the first frequency signal with an output of the frequency divider to generate an LO signal. In this manner, the LO generator may generate a desired LO signal while substantially rejecting or suppressing an unwanted sideband or image signal, according to an example embodiment.

Abstract: A multiple stage band pass filter of a Radio Frequency (RF) Integrated Circuit is provided with a low pass mixer output filter coupled to receive a down sampled analog information signal, a buffer coupled to an output of the low pass mixer output filter, a low pass buffer output filter coupled to an output of the buffer and a plurality of band pass filters coupled to an output of the low pass buffer output filter.

Abstract: A multiple stage band pass filter of a Radio Frequency (RF) Integrated Circuit is provided with a low pass mixer output filter coupled to receive a down sampled analog information signal, a buffer coupled to an output of the low pass mixer output filter, a low pass buffer output filter coupled to an output of the buffer and a plurality of band pass filters coupled to an output of the low pass buffer output filter.

Abstract: Configuring a multiple stage band pass filter of a radio frequency receiver commences by setting a corner of a low pass mixer output filter that receives a down sampled analog information signal. Operation continues with setting a buffer output filter corner of a low pass buffer output filter coupled to an output of low pass mixer output filter via a buffer. Then, operation includes setting the poles and zero of a plurality of band pass filters coupled to the output of the low pass buffer output filter is performed. This operation includes first setting a zero of a respected band pass filter and then setting the plurality of poles of the band pass filter. Finally, operation concludes with setting a combined gain of the combination of the low pass mixer output filter, the low pass buffer output filter, and the plurality of band pass filters.

Abstract: Various embodiments are disclosed relating filter calibration with cell re-use. According to an example embodiment, an apparatus includes a first circuit, including a variable circuit element. The first circuit is adapted to output an output frequency signal during a calibration mode and to operate as a filter during a filter mode. A control circuit is coupled to the first circuit and is adapted to receive a reference frequency signal and to calibrate the first circuit by adjusting the variable circuit element based on the reference frequency signal and the output frequency signal during the calibration mode. The calibrated first circuit is configured to then operate as a filter during the filter mode.