Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.

Abstract: The present invention provides a method of treatment and composition for CDC7 inhibitor combinational therapy for treatment of proliferative diseases. In an embodiment, the composition of the present invention comprises a therapeutically effective amount of a combination of a CDC7 inhibitor of the present invention or a pharmaceutically acceptable salt thereof and one or more antineoplastic agents. In an embodiment, the CFC7 inhibitor comprises granaticin B. In an embodiment, the antneoplastic agent comprises azacitidine and venetoclax. The present invention further provides a method of treatment comprising the step of administration to a subject suffering from proliferative disease of any embodiment of the composition of the present invention.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.

Abstract: In one embodiment a hanger has two interlocking regions, each located at the lower corners of the hanger arms. The interlocking regions have a hole that extends at least part way through the body of the hanger and an extruded lip that extends beyond the body of the hanger at the interlocking region. In one embodiment the outer surface of the interlocking region is narrower than the upper hanging arms of the hanger and the outer edge of the extruded lip is substantially co-planar with the outer surface of the upper hanging arms. This allows the upper hanging arms to be in direct contact with each other when the two hangers are locked together, creating a smooth upper surface.

Abstract: In one embodiment a hanger has two interlocking regions, each located at the lower corners of the hanger arms. The interlocking regions have a hole that extends at least part way through the body of the hanger and an extruded lip that extends beyond the body of the hanger at the interlocking region. In one embodiment the outer surface of the interlocking region is narrower than the upper hanging arms of the hanger and the outer edge of the extruded lip is substantially co-planar with the outer surface of the upper hanging arms. This allows the upper hanging arms to be in direct contact with each other when the two hangers are locked together, creating a smooth upper surface.

Abstract: A method for synchronizing scanning speed and data transmission speed of a scanner to eliminate a traditional memory buffer is disclosed. The scanner is connected to a host computer and comprises a charge coupled device (CCD) for converting a line image reflected from a document to be scanned into an array of analog signals. The CCD comprises an analog memory array for storing the analog signals. The method comprises the following steps of:a) outputting an analog signal from the analog memory array;b) converting the analog signal to a digital signal and transmitting the digital signal to the host computer;c) waiting until the host computer acknowledges receiving of the digital signal; andd) repeating steps a) to c) until all the analog signals stored in the analog memory array are processed and transmitted to the host computer.