Abstract: One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring B is: a monocyclic aromatic group; or a monocyclic or bicyclic heteroaromatic group, each of which is optionally substituted by halo, CN, OH, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, hydroxycycloalkyl, O-cycloalkyl, alkoxy, haloalkoxy, heterocycloalkyl, O-heterocycloalkyl, aryl, heteroaryl, O-aryl, NHCO-alkenyl, NHCO-aryl, —(CH2)q—O-heteroaryl, CONH-aryl, aryloxy-alkyl, O-aralkyl, and CO2-alkyl, wherein said aryl, heteroaryl, heterocycloalkyl, O-cycloalkyl, NHCO-aryl, —(CH2)q—O-heteroaryl, CONH-aryl, aryloxy-alkyl, O-aralkyl, and O-aryl groups are each optionally further substituted by one or more groups independently selected from halo, alkyl, haloalkyl, alkoxy, NHCO-alkyl, NR13R13?, SO2-alkyl, CN, hydroxyalkyl, CONR14R14?, alkyl-NR15R15?, heterocycloalkyl, alkyl-heterocycloalkyl, alkyl-cycloalkyl, aryl, (CH2)m—NHSO2-alkyl, CO2R16, alkoxy-alkyl, haloalkoxy, O-hete

Abstract: One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) ring A is an is optionally substituted 5 or 6 membered aromatic or heteroaromatic ring; Y is selected from CH2, C?N—OH, and CR10R10?; Ra and Rb are each independently selected from H and alkyl; Z is selected from O, S, NR17 and CR18; X is selected from O and NH; p is 0, 1 or 2; q is 0 or 1; and r is 0 or 1; wherein at least one of p, q and r is other than zero, and with the proviso that: (i) when r is 0, p is 1 and q is 1, when X is NH, Z is other than O; (ii) when r and q are both 0, and p is 1, Z is not O; R1, R4, and R5 are each independently selected from H, alkyl, alkoxy, OH, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, haloalkyl, haloalkoxy and CO2-alkyl; R10 and R10? are each independently selected from H, F, alkyl, and haloalkyl; R15 and R16 are each independently selected from H, alkoxy, alkyl and OH; R17 is selected from H,

Abstract: The present invention relates to compounds of formula (I) as GPR65 modulators for the treatment of a proliferative disorder, such as e.g. cancer, an immune disorder, asthma, chronic obstructive pulmonary disease (CORD) or acute respiratory distress syndrome (ARDS). Preferred compounds are e.g. N-(Pyridin-2-yl)-6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[c]pyridine-10-carboxamide derivatives and similar compounds, such as e.g.

Abstract: One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5 or 6 membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, and aralkyl; Y is selected from C?N—OH and CR10R10?, wherein R10 and R10?, are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R11 and R11? wherein R12 and R13 are both alkyl; for use as a medicament.

Abstract: The present invention relates to a compound of formula (Ia), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5- or 6-membered monocyclic aromatic or heteroaromatic ring, or a 9- or 10-membered bicyclic aromatic or heteroaromatic ring, each of which is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, SO2-alkyl, CO2-alkyl, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, and aralkyl; Y and Z are each independently CR10R10?, wherein R10 and R10? are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, I and haloalkyl; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, and haloalkyl; wherein at least two of R2, R3 and R4 are other

Abstract: Systems and methods for rendering media content are provided. Systems of the invention can comprise a first platform for accessing, storing and distributing media content, wherein the media content comprises an unrenderable state when received by the first platform; a second platform communicatively coupled with the first platform for rendering the stored media content; the first and second platforms cooperatively providing an interface for purchasing a right to render stored or accessible media content at least one time; and at least one of the first platform and the second platform being operable to convert the stored or accessible media content to a renderable state upon the purchase of the right to render, wherein the first and second platforms are communicatively coupled to the Internet. Systems are preferably operably connected to the Internet and can provide access to content sources local to and remote from the system of the invention.

Abstract: A hazardous vehicle alert system comprising a control module, a special graphical user interface, a speed and distance detector, and an alarm module where the user sets alarm triggers based on reaction time until potential impact from the hazardous vehicle. The user can assess the landscape, traffic patterns, and specifics of the task at hand to determine the required reaction time to take evasive maneuvers from the threat of on-coming hazardous vehicles and create alarm triggers to yield this reaction time. A software package is used to drive the graphical user interface, control module, alarm module, and detector module. The system includes modes ranging from one to four pieces and a mode that can be installed in a vehicle.

Abstract: A hazardous vehicle alert system comprising a control module, a special graphical user interface, a speed and distance detector, and an alarm module where the user sets alarm triggers based on reaction time until potential impact from the hazardous vehicle. The user can assess the landscape, traffic patterns, and specifics of the task at hand to determine the required reaction time to take evasive maneuvers from the threat of on-coming hazardous vehicles and create alarm triggers to yield this reaction time. A software package is used to drive the graphical user interface, control module, alarm module, and detector module. The system includes modes ranging from one to four pieces and a mode that can be installed in a vehicle.

Abstract: A system for rendering media content in accordance with the invention includes a first platform for storing media content, wherein the media content comprises an unrenderable state when received by the first platform. The system further includes a second platform that is communicatively coupled with the first platform for rendering the stored media content. The first and second platforms cooperatively provide an interface for purchasing a right to render the stored, protected media content at least one time. In the system, at least one of the first and second platforms is operable to convert the stored media content to a renderable state upon the purchase of the right to render.

Abstract: Systems and methods for rendering media content are provided. Systems of the invention can comprise a first platform for accessing, storing and distributing media content, wherein the media content comprises an unrenderable state when received by the first platform; a second platform communicatively coupled with the first platform for rendering the stored media content; the first and second platforms cooperatively providing an interface for purchasing a right to render stored or accessible media content at least one time; and at least one of the first platform and the second platform being operable to convert the stored or accessible media content to a renderable state upon the purchase of the right to render, wherein the first and second platforms are communicatively coupled to the Internet. Systems are preferably operably connected to the Internet and can provide access to content sources local to and remote from the system of the invention.