Patents by Inventor Tom Merchiers

Tom Merchiers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PRODUCTION AND PURIFICATION OF MULTIVALENT IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20230136595
    Abstract: The present disclosure relates to an improved method for the manufacture of polypeptides comprising at least three or at least four immunoglobulin single variable domains (ISVDs). More specifically, an improved method is provided of producing, purifying and isolating polypeptides comprising at least three or at least four ISVDs in which an undesired product-related conformational variant is reduced or absent.
    Type: Application
    Filed: March 30, 2021
    Publication date: May 4, 2023
    Applicant: Ablynx NV
    Inventors: Florian Madura, Sonia Letestu, Ann Brigé, Tom Merchiers, Ellen Van Horen, Chakib Borsali
  • NUCLEOTIDE SEQUENCES ENCODING PEPTIDE LINKERS
    Publication number: 20200392512
    Abstract: The invention provides improved nucleotide sequences and nucleic acids that encode glycine serine linkers and that use an excess of GGA, GGG, and GGT/GGU codons to encode the glycine residues. The invention further relates to nucleotide sequences and nucleic acids that encode (fusion) proteins and polypeptides comprising glycine serine linkers, which nucleotide sequences and nucleic acids comprise such improved nucleotide sequences and nucleic acids of the invention.
    Type: Application
    Filed: February 26, 2019
    Publication date: December 17, 2020
    Applicant: Ablynx N.V.
    Inventors: Veronique De Brabandere, Ann Brige, Patrick Stanssens, Pieter-Jan De Bock, Tom Merchiers, Antonin De Fougerolles