Abstract: A body support cushion, e.g., mattress, has multiple foam layers, including a viscoelastic foam layer and a reticulated foam layer, and an outer cover. At least one of the foam layers and the outer cover each includes phase change material having latent heat properties that provide two intervals of dermal cooling.

Abstract: Provided are methods of targeting patient-specific oncogenes in extrachromosomal DNA (ecDNA) to treat glioma in a human. The present methods include identifying a drug that targets against an oncogene present in ecDNA of a human suffering from glioma, such as glioblastoma. The identified oncogenes present in ecDNA include MET, MET/CAPZA2, MDM2, CDK4, SOX2, PIK3CA, MECOM, PDGFRA, EGFR, MYCN, MYC, TERT, SMARCA4, RP56, FBXW7, CDK6, CCND2, ERBB2, BRCA1, and BAP1. The present methods include identifying a drug targeted against the ecDNA oncogene, which drug inhibits the function of the identified oncogene, so as to inhibit tumor growth or progression of the glioma in the human. Also provided are PDX mouse models to further identify and/or confirm patient-specific drugs that target the identified oncogene(s) present in ecDNA. Also provided are methods of diagnosing gliomas or recurrent gliomas and methods of screening or monitoring for recurrence of gliomas.

Abstract: A body support cushion, e.g., mattress, has multiple foam layers, including a viscoelastic foam layer and a reticulated foam layer, and an outer cover. At least one of the foam layers and the outer cover each includes phase change material having latent heat properties that provide two intervals of dermal cooling.

Abstract: A body support cushion, e.g., mattress, has multiple foam layers, including a viscoelastic foam layer and a reticulated foam layer, and an outer cover. At least one of the foam layers and the outer cover each includes phase change material having latent heat properties that provide two intervals of dermal cooling.

Abstract: A support cushion for providing individualized heating and cooling to a user resting on the support cushion is provided. The support cushion includes a body supporting portion, a plurality of thermoelectric elements positioned and configured to selectively provide heating or cooling of the body supporting portion, and a heat dissipating portion that is comprised of a thermally-absorbent material and is operably connected to the thermoelectric elements. Methods of controlling a surface temperature of a support cushion are also provided.

Abstract: A support cushion for is provided that includes a core comprised of a first flexible foam and a sleeve comprised of a second flexible foam. The sleeve has a first side and a second side opposite the first side that together encapsulate the core. The support cushion further includes an amount of phase change material that is incorporated into at least one of the first side or the second side of the sleeve.

Abstract: A support cushion for providing individualized heating and cooling to a user resting on the support cushion is provided. The support cushion includes a body supporting layer, a plurality of thermoelectric elements positioned and configured to selectively provide heating or cooling of the body supporting layer, a heat transfer layer positioned adjacent to the body supporting portion and operably connected to the thermoelectric elements, a base layer positioned adjacent to the heat transfer layer opposite the body supporting layer and defining one or more inlet and outlet conduits, and one or more fans operably connected to each of the outlet conduits. Methods of controlling the surface temperature of a support cushion are also provided.

Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.

Abstract: A mattress assembly includes a foundation that defines first and second axes oriented along the length and the width of the foundation, respectively. The mattress assembly further includes a mattress supported atop the foundation and means for securing the mattress to the foundation to inhibit sliding movement of the mattress relative to the foundation along at least one of the first and second axes.

Abstract: A mattress assembly is provided that includes a body supporting portion, one or more air bladders positioned beneath the body supporting portion, and a frame portion. The frame portion includes a bottom surface and a sidewall that collectively define a well for receiving the one or more air bladders. The sidewall of the frame portion is secured to the second surface of the body supporting portion at a foot portion of the mattress assembly, while the sidewall of the frame portion and the body supporting portion are configured to move relative to one another at a head portion and a middle portion of the mattress assembly to thereby allow the mattress assembly to conform to the shape of an adjustable foundation.

Abstract: A body support cushion, e.g., mattress, has multiple foam layers, including a viscoelastic foam layer and a reticulated beat properties that provide two intervals of dermal cooling.

Abstract: A support cushion for providing individualized heating and cooling to a user resting on the support cushion is provided. The support cushion includes a body supporting portion, a plurality of thermoelectric elements positioned and configured to selectively provide heating or cooling of the body supporting portion, and a heat dissipating portion that is comprised of a flexible foam having a plurality of cells with a reticulated cellular structure and that is operably connected to the thermoelectric elements. Methods of controlling a surface temperature of a support cushion are also provided.

Abstract: A body support cushion, such as a mattress, mattress topper or overlay, or pillow, is comprised of a layer of flexible foam and further has a volume of gelatinous material, e.g., elastomer gel, applied to a surface thereof. The gelatinous material alters a physical property, such as firmness or feel, of the layer of flexible foam. The gelatinous material can be applied in a number of ways including, but not limited to a spray application whereupon the spray force can be used to control how much gelatinous material penetrates into the layer of foam. The foam layer may be comprised of reticulated or non-reticulated foam. The foam layer may also be comprised of viscoelastic or non-viscoelastic foam.

Abstract: A support cushion for providing individualized heating and cooling to a user resting on the support cushion is provided. The support cushion includes a body supporting portion, a plurality of thermoelectric elements positioned and configured to selectively provide heating or cooling of the body supporting portion, and a heat dissipating portion that is comprised of a thermally-absorbent material and is operably connected to the thermoelectric elements. Methods of controlling a surface temperature of a support cushion are also provided.

Abstract: A mattress assembly includes a foundation that defines first and second axes oriented along the length and the width of the foundation, respectively. The mattress assembly further includes a mattress supported atop the foundation and means for securing the mattress to the foundation to inhibit sliding movement of the mattress relative to the foundation along at least one of the first and second axes.

Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.

Abstract: A body support comprising at least one layer of flexible material having a reticulated cellular structure is disclosed. In some embodiments, one or more of these layers comprises reticulated visco-elastic foam, and has at least one material property responsive to temperatures in the range of a user's body heat. In these and other embodiments, one or more of the layers of flexible material comprises non-visco-elastic foam, and can be combined in a body support with one or more layers of visco-elastic foam. The body support can include one or more additional layers of other material types, including one or more layers of high-resilience polyurethane foam. Also, in those embodiments having two or more layers of material, one or more of the layers can have a profiled surface at least partially defining air flow paths through the body support.

Abstract: A body support comprising a top layer of flexible visco-elastic material having an exposed convoluted top surface is disclosed. The flexible visco-elastic material can have a reticulated or non-reticulated cellular structure. In some embodiments, one or more other layers of the body support comprises reticulated visco-elastic foam, and can have at least one material property responsive to temperatures in the range of a user's body heat. In these and other embodiments, one or more of the other layers of flexible material comprises non-visco-elastic foam, and can be combined in a body support with one or more layers of visco-elastic foam. The body support can include one or more layers of other material types, including one or more layers of high-resilience polyurethane foam.