Abstract: A method of generating a calibration factor is described. In an example, the method may include establishing a wireless communication connection with a fitness machine. The method may also include obtaining first machine data from the fitness machine. The first machine data may specify a type of the fitness machine. The method may also include initiating a workout session on the wearable computer based on the first machine data. During the workout session, the method may also include obtaining sensor data, obtaining second machine data, and determining the calibration factor based on the second machine data and the sensor data. The method may also include generating a workout session summary based on the calibration factor.

Abstract: Method and device for the extrusion of thermomechanically deformable materials, as well as a compact screw extruder. The configuration of the material infeed in a screw extruder, has a significantly smaller length-diameter ratio than known solutions from the fields of injection moulding and additive manufacturing and a crushing tool, located in the funnel-shaped infeed region of the vertically arranged screw extruder which prevents the rotational movement of the material in the funnel, and also thereby forces movement in the conveying direction of the screw extruder in combination with the gradient of the screw flanks. In addition, a portion of the coarse material is crushed, whereby the bulk material density is increased in the region of the screw and less air must be pressed out of the material in the region of the plasticization and homogenization zone.

Abstract: Embodiments are disclosed for a wearable computer with fitness machine connectivity for improved activity monitoring. In an embodiment, a method comprises: establishing, by a processor of a wireless device, a wireless communication connection with a fitness machine; obtaining, by the processor, machine data from the fitness machine; determining, by the processor, a workout session according to the machine data; initiating the workout session on the wireless device; during the workout session: obtaining, from a sensor of the computing device, physiological data of a user of the fitness machine; determining, by the processor, fitness data for the user based on the physiological data, the machine data and at least one user characteristic; and sending, by the processor, the fitness data to the fitness machine.

Abstract: Embodiments are disclosed for a wearable computer with fitness machine connectivity for improved activity monitoring. In an embodiment, a method comprises: establishing, by a processor of a wireless device, a wireless communication connection with a fitness machine; obtaining, by the processor, machine data from the fitness machine; determining, by the processor, a workout session according to the machine data; initiating the workout session on the wireless device; during the workout session: obtaining, from a sensor of the computing device, physiological data of a user of the fitness machine; determining, by the processor, fitness data for the user based on the physiological data, the machine data and at least one user characteristic; and sending, by the processor, the fitness data to the fitness machine.

Abstract: A method of adjusting a hydraulic drive system includes determining a forward park position value, a reverse park position value, an initial forward position value, and an initial reverse position value of a control device and using these values to calculate a forward buffer value and a reverse buffer value. The forward buffer value and the reverse buffer value are used to determine an adjustment amount for the drive system. The adjustment amount can be used to properly adjust a drive system to avoid system errors.

Abstract: A method of adjusting a hydraulic drive system includes determining a forward park position value, a reverse park position value, an initial forward position value, and an initial reverse position value of a control device and using these values to calculate a forward buffer value and a reverse buffer value. The forward buffer value and the reverse buffer value are used to determine an adjustment amount for the drive system. The adjustment amount can be used to properly adjust a drive system to avoid system errors.

Abstract: The invention features compositions and methods that are useful for the measurement of the quantity of a nucleic acid target in a sample.

Abstract: The invention features compositions and methods that are useful for the measurement of the quantity of a nucleic acid target in a sample.

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract: A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.

Abstract: A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.

Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.

Abstract: An improved assay for identifying and distinguishing one or more a single nucleotide polymorphisms in one or more target sequences of nucleic acid comprises, in a single-tube reaction system, three or more primers, two of which bind to a target nucleic acid sequence, flanking a SNP, so that the 3?-end of one or more first primers is adjacent to the 5?-end of a second primer, the two primers being selectively ligated and then amplified by a third primer to exponentially produce the complementary strand of the one or more target sequences. The other strand of the one or more target sequences are exponentially amplified by one or more hybridizable probes, each labeled with a different fluorophore, the fluorophore-labeled hybridizable probes being quenched until incorporation into and amplification of target nucleic acid products.

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.