Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: A method of forming a wear-resistant coating on a surface of a substrate includes the step of depositing a material comprising a rhenium-based composition onto the substrate surface using a handheld laser deposition device. A soluble interlayer may be formed on the surface of the substrate prior to the laser deposition step, and a heat treatment may be performed after the laser deposition step.

Abstract: A welding guide nozzle for precision weld positioning of a feedstock material in a welding system. The welding guide nozzle includes a nozzle structure defining a substantially cylindrical holding apparatus that tapers at one end to define a nozzle tip. The holding apparatus and the nozzle tip include concentric bores defined therein. An erosion resistant rod is disposed within the bore defined in the nozzle tip. The erosion resistant rod includes a bore defined therein into with the weld feedstock material is disposed. The erosion resistant material is formed of a high heat resistive material thereby permitting positioning in close proximity to a heat source.

Abstract: A covering of a convertible top compartment of a convertible which has a convertible top which can be deposited in a convertible top compartment, the covering having at least one first cover part and one second cover part which are supported to be able to pivot relative to one another.