Patents by Inventor Tom Payne
Tom Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230183751Abstract: The invention relates to a method for promoting the modification, preferably by homology-dependent repair (HDR), of a target site in a genome of a cell. The method comprises the steps of introducing a template DNA molecule and one or more DNA repair inhibitors into a cell which comprises or is capable of expressing a site-specific DNA endonuclease (e.g. Cas12a). The DNA repair inhibitors comprise BAY598, together with one or more other inhibitors. The invention also relates to kits comprising the aforementioned DNA repair inhibitors.Type: ApplicationFiled: May 20, 2021Publication date: June 15, 2023Inventors: Ryan Cawood, Tom Payne, Suzanne Snellenberg, Abhishek Srivastava
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Publication number: 20230183750Abstract: The invention relates to a method for promoting the modification, preferably by homology-dependent repair (HDR), of a target site in a genome of a cell. The method comprises the steps of introducing a template DNA molecule and one or more DNA repair inhibitors into a cell which comprises or is capable of expressing a site-specific DNA endonuclease (e.g. Cas9). The DNA repair inhibitors comprise one or more aurora kinase inhibitors, wherein the aurora kinase inhibitors are selected from the group consisting of AT9283, PHA-680632, TAK-901 and CCT137690, together with one or more other inhibitors. The invention also relates to kits comprising the aforementioned DNA repair inhibitors.Type: ApplicationFiled: May 20, 2021Publication date: June 15, 2023Inventors: Ryan Cawood, Tom Payne, Suzanne Snellenberg, Abhishek Srivastava
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Patent number: 11667929Abstract: The present invention relates to nucleic acid molecules comprising viral genes or derivatives thereof for use in the production of retroviral packaging vectors, and retroviral packaging and producer cell lines. In one embodiment, the nucleic acid molecules comprise env and gag-pol genes wherein the coding sequences of the env and gag-pol genes are in opposing orientations.Type: GrantFiled: September 18, 2018Date of Patent: June 6, 2023Assignee: Oxford Genetics LimitedInventors: Ryan Cawood, Tom Payne, Lucia Dunajova, Richard Parker-Manuel
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Publication number: 20220162636Abstract: The invention relates to nucleic acid molecules, vectors and plasmids comprising AAV cap genes and rep genes, wherein the cap and rep genes are both operably-associated with an inducible promoter which comprises one or more cumate operator (CuO) sequences. The invention further relates to producer and packaging cell lines which are useful in the production of Adeno-Associated Virus (AAV) particles.Type: ApplicationFiled: February 5, 2020Publication date: May 26, 2022Inventors: Ryan Cawood, Tom Payne, Alissa Bray
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Publication number: 20200277629Abstract: The present invention relates to nucleic acid molecules comprising viral genes or derivatives thereof for use in the production of retroviral packaging vectors, and retroviral packaging and producer cell lines. In one embodiment, the nucleic acid molecules comprise env and gag-pol genes wherein the coding sequences of the env and gag-pol genes are in opposing orientations.Type: ApplicationFiled: September 18, 2018Publication date: September 3, 2020Inventors: Ryan CAWOOD, Tom PAYNE, Lucia DUNAJOVA, Richard PARKER-MANUEL
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Publication number: 20200002721Abstract: The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5? of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus.Type: ApplicationFiled: April 2, 2019Publication date: January 2, 2020Inventors: Tom Payne, Robert Young, Marc Feary
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Patent number: 10294491Abstract: The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5? of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus.Type: GrantFiled: August 28, 2017Date of Patent: May 21, 2019Assignee: LONZA BIOLOGICS PLC.Inventors: Tom Payne, Robert Young, Marc Feary
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Publication number: 20170356007Abstract: The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5? of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus.Type: ApplicationFiled: August 28, 2017Publication date: December 14, 2017Inventors: Tom Payne, Robert Young, Marc Feary
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Patent number: 9777290Abstract: The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5? of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus.Type: GrantFiled: September 23, 2013Date of Patent: October 3, 2017Assignee: Lonza Biologics PlcInventors: Tom Payne, Robert Young, Marc Feary
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Patent number: 9612354Abstract: There are systems and methods for performing a geophysical survey using a hybrid aircraft which includes an apparatus configured to perform the geophysical survey. The system including: three mutually orthogonal transmitters configured to transmit electromagnetic (EM) waveforms towards the ground which creates a secondary magnetic field, wherein the three mutually orthogonal transmitters are attached to the hybrid aircraft; three mutually orthogonal null-coupled receivers configured to obtain measurements associated with the secondary magnetic field, wherein the three mutually orthogonal null-coupled receivers are attached to the hybrid aircraft; and three mutually orthogonal gradient receivers configured to obtain measurements, wherein the three mutually orthogonal gradient receivers are attached to the hybrid aircraft.Type: GrantFiled: February 6, 2015Date of Patent: April 4, 2017Assignee: CGG SERVICES SASInventors: Richard Partner, Adam Smiarowski, Tom Payne, Stuart Stevenson, George Nader, Philip Miles
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Publication number: 20160161625Abstract: There are systems and methods for performing a geophysical survey using a hybrid aircraft which includes an apparatus configured to perform the geophysical survey. The system including: three mutually orthogonal transmitters configured to transmit electromagnetic (EM) waveforms towards the ground which creates a secondary magnetic field, wherein the three mutually orthogonal transmitters are attached to the hybrid aircraft; three mutually orthogonal null-coupled receivers configured to obtain measurements associated with the secondary magnetic field, wherein the three mutually orthogonal null-coupled receivers are attached to the hybrid aircraft; and three mutually orthogonal gradient receivers configured to obtain measurements, wherein the three mutually orthogonal gradient receivers are attached to the hybrid aircraft.Type: ApplicationFiled: February 6, 2015Publication date: June 9, 2016Inventors: Richard PARTNER, Adam SMIAROWSKI, Tom PAYNE, Stuart STEVENSON, George NADER, Philip MILES
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Publication number: 20150218584Abstract: The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5? of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus.Type: ApplicationFiled: September 23, 2013Publication date: August 6, 2015Inventors: Tom Payne, Robert Young, Marc Feary
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Publication number: 20060221595Abstract: A lamp assembly adapted for underwater use including a guard tube adapted for being filled with water and for forming a hollow housing for the lamp assembly and an inner tube positioned within the guard tube to provide a waterproof environment for the lamp assembly.Type: ApplicationFiled: March 31, 2005Publication date: October 5, 2006Inventor: Tom Payne
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Patent number: D711573Type: GrantFiled: January 5, 2012Date of Patent: August 19, 2014Inventor: Tom Payne
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Patent number: D726355Type: GrantFiled: September 30, 2012Date of Patent: April 7, 2015Inventor: Tom Payne
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Patent number: D690452Type: GrantFiled: June 25, 2012Date of Patent: September 24, 2013Inventor: Tom Payne