Patents by Inventor Tom Tong Lee

Tom Tong Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOMIC ENGINEERING OF PLURIPOTENT CELLS
    Publication number: 20200095604
    Abstract: Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.
    Type: Application
    Filed: October 17, 2019
    Publication date: March 26, 2020
    Inventors: Bahram VALAMEHR, Ramzey ABUJAROUR, Tom Tong LEE, Weijie LAN, Raedun CLARKE, Ryan BJORDAHL
  • ENHANCED IMMUNE EFFECTOR CELLS AND USE THEREOF
    Publication number: 20200069734
    Abstract: Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
    Type: Application
    Filed: September 19, 2019
    Publication date: March 5, 2020
    Inventors: Bahram VALAMEHR, Ryan BJORDAHL, Jode GOODRIDGE, Tom Tong LEE
  • GENOMIC ENGINEERING OF PLURIPOTENT CELLS
    Publication number: 20190271005
    Abstract: Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.
    Type: Application
    Filed: April 9, 2019
    Publication date: September 5, 2019
    Inventors: Bahram Valamehr, Ramzey Abujarour, Tom Tong Lee, Weijie Lan, Raedun Clarke, Ryan Bjordahl
  • Genomic engineering of pluripotent cells
    Patent number: 10287606
    Abstract: Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: May 14, 2019
    Assignee: Fate Therapeutics, Inc.
    Inventors: Bahram Valamehr, Ramzey Abujarour, Tom Tong Lee, Weijie Lan, Raedun Clarke, Ryan Bjordahl
  • GENOMIC ENGINEERING OF PLURIPOTENT CELLS
    Publication number: 20180155717
    Abstract: Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.
    Type: Application
    Filed: November 20, 2017
    Publication date: June 7, 2018
    Inventors: Bahram Valamehr, Ramzey Abujarour, Tom Tong Lee, Weijie Lan, Raedun Clarke, Ryan Bjordahl
  • Wnt compositions and therapeutic uses of such compositions
    Patent number: 9873722
    Abstract: The invention provides novel Wnt polypeptides that have improved production characteristics, solubility, systemic delivery, and tissue uptake, and polynucleotides encoding the Wnt polypeptides of the invention. The Wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 23, 2018
    Assignee: Fate Therapeutics, Inc.
    Inventors: Tom Tong Lee, Michael J. Fitch, Kevin Lai, Peter Flynn, Monica Bennett
  • Wnt compositions and therapeutic uses of such compositions
    Patent number: 9403885
    Abstract: The invention provides novel Wnt polypeptides that have enhanced solubility and improved biologic drug-like properties, and polynucleotides encoding the Wnt polypeptides of the invention. The Wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: August 2, 2016
    Assignee: Fate Therapeutics, Inc.
    Inventors: Tom Tong Lee, Monica Hayhurst Bennett, Michael J. Fitch, Peter Flynn
  • WNT COMPOSITIONS AND THERAPEUTIC USES OF SUCH COMPOSITIONS
    Publication number: 20150099708
    Abstract: The invention provides novel Wnt polypeptides that have improved production characteristics, solubility, systemic delivery, and tissue uptake, and polynucleotides encoding the Wnt polypeptides of the invention. The Wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 9, 2015
    Inventors: Tom Tong Lee, Michael J. Fitch, Kevin Lai, Peter Flynn, Monica Bennett
  • CARDIOTROPHIN RELATED MOLECULES FOR ENHANCED THERAPEUTICS
    Publication number: 20140171625
    Abstract: The invention provides novel polypeptides having at least one biological activity of cardiotrophin and improved biologic drug-like properties, and polynucleotides encoding the polypeptides of the invention. The polypeptides of the invention can be used therapeutically, such as, for example, in methods of tissue regeneration.
    Type: Application
    Filed: February 1, 2012
    Publication date: June 19, 2014
    Applicant: Fate Therapeutics, Inc.
    Inventors: Tom Tong Lee, Kevin Lai, John Mendlein, Peter Flynn
  • NOVEL WNT COMPOSITIONS AND THERAPEUTIC USES OF SUCH COMPOSITIONS
    Publication number: 20140142046
    Abstract: The invention provides novel Wnt polypeptides that have enhanced solubility and improved biologic drug-like properties, and polynucleotides encoding the Wnt polypeptides of the invention. The Wnt polypeptides of the invention can be used therapeutically, such as, for example, in methods of preventing or treating muscle loss and/or promoting muscle hypertrophy and growth.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 22, 2014
    Applicant: FATE THERAPEUTICS, INC.
    Inventors: Tom Tong Lee, Monica Hayhurst Bennett, Michael J. Fitch, Peter Flynn