Patents by Inventor Tom W. Muir

Tom W. Muir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220275027
    Abstract: The present disclosure relates to atypical split N- and C-inteins and variants thereof. This disclosure also relates to complexes comprising the split N- or C-inteins of this disclosure and a compound of interest and compositions comprising said complexes. In addition, this disclosure relates to methods of using the atypical split N- and C-inteins.
    Type: Application
    Filed: August 28, 2019
    Publication date: September 1, 2022
    Inventors: TOM W. MUIR, ADAM STEVENS, JOSEF GRAMESPACHER, DAVID COWBURN, GIRIDHAR SEKAR
  • Publication number: 20220220134
    Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 14, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Tom W. Muir, Rob C. Oslund, Jung-Min Kee
  • Publication number: 20220098293
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Publication number: 20210371467
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 2, 2021
    Inventors: Tom W. MUIR, Adam J. STEVENS, Neel H. SHAH
  • Patent number: 11161899
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: November 2, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Patent number: 11142550
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 12, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Adam J. Stevens, Neel H. Shah
  • Patent number: 11084849
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: August 10, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Adam J. Stevens, Neel H. Shah
  • Publication number: 20200087388
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Publication number: 20200055900
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 20, 2020
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. MUIR, Adam J. STEVENS, Neel H. SHAH
  • Patent number: 10526401
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 7, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Patent number: 10351581
    Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 16, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Rob C. Oslund, Jung-Min Kee
  • Publication number: 20190092796
    Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.
    Type: Application
    Filed: September 19, 2018
    Publication date: March 28, 2019
    Applicant: The Trustees of Princeton University
    Inventors: Tom W. Muir, Rob C. Oslund, Jung-Min Kee
  • Publication number: 20190093159
    Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.
    Type: Application
    Filed: August 24, 2018
    Publication date: March 28, 2019
    Applicant: The Trustees of Princeton University
    Inventors: Tom W. MUIR, Uyen T. T. NGUYEN, Manuel M. MUELLER
  • Patent number: 10087485
    Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: October 2, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Tom W. Muir, Uyen T. T. Nguyen, Manuel M. Mueller
  • Publication number: 20180057577
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 1, 2018
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Patent number: 9765154
    Abstract: The present invention relates to the phosphohistidine analogs of the present invention which of the formula and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: September 19, 2017
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Tom W. Muir, Jung-Min Kee
  • Publication number: 20160311838
    Abstract: Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.
    Type: Application
    Filed: October 2, 2014
    Publication date: October 27, 2016
    Inventors: Tom W. Muir, Rob C. Oslund, Jung-Min Kee
  • Publication number: 20150344589
    Abstract: The present invention relates to the phosphohistidine analogs of the present invention which of the formula and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.
    Type: Application
    Filed: May 11, 2015
    Publication date: December 3, 2015
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Tom W. MUIR, Jung-Min KEE
  • Publication number: 20150344549
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest. Thus, provided herein are fusion proteins of a polypeptide and a split intein N-fragment, or variant thereof, as described below in greater detail. Also provided are complexes of the fusion protein and a split intein C-fragment or variant thereof as described in detail below. The complex of the fusion protein and C-fragment or variant thereof can be via a covalent interaction between the fusion protein and C-fragment or variant or via a noncovalent interaction (e.g., ionic, H-bonding, and/or van der Waals interaction). Further provided herein are split intein C-fragments or variants thereof.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 3, 2015
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Publication number: 20150197801
    Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.
    Type: Application
    Filed: June 6, 2013
    Publication date: July 16, 2015
    Applicant: The Trustees of Princeton University
    Inventors: Tom W. Muir, Uyen T.T. Nguyen, Manuel M. Mueller