Patents by Inventor Tom Wehrman

Tom Wehrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of Molecular Interactions Using a Reduced Affinity Enzyme Complementation Reporter System
    Publication number: 20140178913
    Abstract: Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
    Type: Application
    Filed: September 24, 2013
    Publication date: June 26, 2014
    Inventors: Tom Wehrman, Helen M. Blau
  • Detection of molecular interactions using a reduced affinity enzyme complementation reporter system
    Patent number: 8541175
    Abstract: Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: September 24, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tom Wehrman, Helen M. Blau
  • Detection of sub-cellular compartment localization of a molecule using a reduced affinity enzyme complementation reporter system
    Patent number: 8426138
    Abstract: Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: April 23, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. Blau, Mark Morris Hammer, Tom Wehrman
  • DETECTION OF SUB-CELLULAR COMPARTMENT LOCALIZATION OF A MOLECULE USING A REDUCED AFFINITY ENZYME COMPLEMENTATION REPORTER SYSTEM
    Publication number: 20100285451
    Abstract: Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
    Type: Application
    Filed: December 26, 2007
    Publication date: November 11, 2010
    Inventors: Helen M. Blau, Mark Hammer, Tom Wehrman
  • Sequential reporter enzyme luminescence (SRL) methods and compositions for practicing the same
    Patent number: 7582417
    Abstract: Sequential reporter enzyme luminescence (SRL) methods are provided. In the subject methods, the activity of a reporter enzyme is evaluated using a secondary reporter system that employs a product of a reporter enzyme mediated reaction as a luminescent substrate, e.g., luciferase substrate. Also provided are kits and other compositions that find use in practicing the subject methods.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: September 1, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tom Wehrman, Georges J. Von Degenfeld, Helen M. Blau
  • Attenuated Effector Ligand
    Publication number: 20080166806
    Abstract: Methods and compositions are provided for effecting physiological processes using a conjugate of a binding member binding to a surface membrane marker and a ligand for a cell surface receptor, where the ligand is attenuated as compared to the natural ligand. The composition finds particular application in discriminating between cells that share the receptor and can be distinguished by the surface membrane marker.
    Type: Application
    Filed: January 8, 2007
    Publication date: July 10, 2008
    Inventor: Tom Wehrman
  • Methods and Compositions for Use in Preparing Hairpin Rnas
    Publication number: 20080021205
    Abstract: Methods and compositions for producing hRNA, e.g., shRNA, expression modules for specific target nucleic acids are provided. In the subject methods, an initial nucleic acid, e.g., dsDNA, synthetic DNA, etc., corresponding to the target nucleic acid of interest is converted to an intermediate nucleic acid. The resultant intermediate nucleic acid, following an optional size modification step, is then converted to a linear dsDNA that includes at least one copy of the hRNA expression module of interest, or a precursor (i.e., pro-shRNA expression module) thereof, where in certain embodiments conversion may include amplification. Also provided are reagents, systems and kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.
    Type: Application
    Filed: December 10, 2004
    Publication date: January 24, 2008
    Inventors: Helen Blau, George Sen, Jason Meyers, Tom Wehrman
  • Detection of molecular interactions using a reduced affinity enzyme complementation reporter system
    Publication number: 20070275397
    Abstract: Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
    Type: Application
    Filed: March 12, 2007
    Publication date: November 29, 2007
    Inventors: Tom Wehrman, Helen Blau
  • Sequential reporter enzyme luminescence (SRL) methods and compositions for practicing the same
    Publication number: 20070224621
    Abstract: Sequential reporter enzyme luminescence (SRL) methods are provided. In the subject methods, the activity of a reporter enzyme is evaluated using a secondary reporter system that employs a product of a reporter enzyme mediated reaction as a luminescent substrate, e.g., luciferase substrate. Also provided are kits and other compositions that find use in practicing the subject methods.
    Type: Application
    Filed: February 14, 2007
    Publication date: September 27, 2007
    Inventors: Tom Wehrman, Georges Von Degenfeld, Helen Blau
  • Novel nucleic acids and polypeptides
    Publication number: 20070049743
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: November 13, 2002
    Publication date: March 1, 2007
    Inventors: Y. Tang, Chenghua Liu, Vinod Asundi, Rui-Hung Chen, Feiyan Ren, Jian-Rui Wang, Tom Wehrman, Aidong Xue, Yonghong Yang, Jie Zhang, Qing Zhao, Ping Zhou, Radoje Drmanac, Ryle Goodrich
  • Novel nucleic acids and polypeptides
    Publication number: 20050266423
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: November 29, 2004
    Publication date: December 1, 2005
    Applicant: NUVELO, Inc.
    Inventors: Y. Tang, Chenghua Liu, Vinod Asundi, Rui-hong Chen, Xiaohong Qian, Zhi Wang, Tom Wehrman, Jie Zhang, Ping Zhou, Yicheng Cao, Radoje Drmanac
  • Novel nucleic acids and polypeptides
    Publication number: 20050239060
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: April 12, 2002
    Publication date: October 27, 2005
    Inventors: Y. Tang, Chenghua Liu, Vinod Asundi, Jie Zhang, Feiyan Ren, Rui-hong Chen, Qing Zhao, Tom Wehrman, Aidong Xue, Yonghong Yang, Jian-Rui Wang, Ping Zhou, Yunqing Ma, Dunrui Wang, Zhiwei Wang, Radoje Drmanac
  • Nucleic acids and polypeptides
    Publication number: 20050221342
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: October 22, 2004
    Publication date: October 6, 2005
    Applicant: NUVELO, Inc.
    Inventors: Y. Tang, Vinod Asundi, Ping Zhou, Aidong Xue, Feiyan Ren, Jie Zhang, Jian-Rui Wang, Yonghong Yang, Qing Zhao, Ryle Goodrich, Chenghua Liu, Radoje Drmanac, Yunqing Ma, Zhiwei Wang, Tom Wehrman
  • Novel nucleic acids and polypeptides
    Publication number: 20050175607
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: February 26, 2001
    Publication date: August 11, 2005
    Inventors: Y Tang, Chenghua Liu, Vinod Asundi, Chongjun Xu, Tom Wehrman, Feiyan Ren, Yunqing Ma, Ping Zhou, Qing Zha, Yonghong Yang, Radoje Drmanac, Jie Zhang, Rui-hong Chen, Jian-Rui Wang, Dunrui Wang, Aidong Xue
  • Novel nucleic acids and polypeptides
    Publication number: 20040137434
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: April 3, 2002
    Publication date: July 15, 2004
    Inventors: Y. Tom Tang, Ping Zhou, Ryle Goodrich, Chenghua Liu, Vinod Asundi, Feiyan Ren, Jie Zhang, Qing A. Zhao, Aidong Xue, Yonghong Yang, Tom Wehrman, Radoje T. Drmanac
  • Nucleic acids and polypeptides
    Patent number: 6743619
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: June 1, 2004
    Assignee: Nuvelo
    Inventors: Y. Tom Tang, Ping Zhou, Ryle Goodrich, Chenghua Liu, Vinod Asundi, Feiyan Ren, Jie Zhang, Qing A. Zhao, Yonghong Yang, Aidong J. Xue, Tom Wehrman, Jian-Rui Wang, Dunrui Wang, Radoje T. Drmanac
  • Novel nucleic acids and secreted polypeptides
    Publication number: 20040048249
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: March 28, 2002
    Publication date: March 11, 2004
    Inventors: Y. Tom Tang, Yonghong Yang, Gezhi Weng, Jie Zhang, Feiyan Ren, Aidong Xue, Jian-Rui Wang, Tom Wehrman, Malabika J. Ghosh, Dunrui Wang, Qing A. Zhao, Zhiwei Wang
  • Novel nucleic acids and polypeptides
    Publication number: 20040044181
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: July 15, 2003
    Publication date: March 4, 2004
    Inventors: Y. Tom Tang, Chenghua Liu, Vinod Asundi, Tom Wehrman, Feiyan Ren, Ping Zhou, Qing A. Zhao, Radoje T. Drmanac, Jie Zhang, Aidong Xue, Jian-Rui Wang, Dunrui Wang
  • Novel nucleic acids and polypeptides
    Publication number: 20040034208
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: June 19, 2003
    Publication date: February 19, 2004
    Inventors: Y. Tom Tang, Chenghua Liu, Vinod Asundi, Chongjun Xu, Tom Wehrman, Feiyan Ren, Yunging Ma, Ping Zhou, Qing A. Zhao, Yonghong Yang, Radoje T. Drmanac, Jie Zhang, Rui-hong Chen, Aidong Xue, Jian-Rui Wang
  • Novel nucleic acids and polypeptides
    Publication number: 20040013657
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Application
    Filed: November 12, 2002
    Publication date: January 22, 2004
    Inventors: Y. Tom Tang, Vinod Asundi, Tom Wehrman, Yonghong Yang, Jie Zhang, Ping Zhou, Radoje T. Drmanac, Ryle Goodrich