Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: A refractory unit for lining a high temperature vessel includes a refractory body formed from a refractory material. The refractory body has an upper main surface, a lower main surface, an inner surface configurable to face a high temperature chamber, an outer surface configurable to face away from the high temperature chamber, a first side surface and a second side surface. An elastic member is attached to the outer surface.

Abstract: A system for determining the gaze endpoint of a subject, the system comprising: a eye tracking unit adapted to determine the gaze direction of one or more eyes of the subject; a head tracking unit adapted to determine the position comprising location and orientation of the eye tracker with respect to a reference coordinate system; a 3D Structure representation unit, that uses the 3D structure and position of objects of the scene in the reference coordinate system to provide a 3D structure representation of the scene; based on the gaze direction, the eye tracker position and the 3D structure representation, calculating the gaze endpoint on an object of the 3D structure representation of the scene or determining the object itself.

Abstract: Novel tools and techniques are provided for implementing software-based network probes for monitoring network devices for fault management. In various embodiments, a computing system may receive, from at least one software-based network probe, a first alert associated with a first device among layer 4 devices disposed in a plurality of networks; may parse and store first alert data from the received first alert in a database, in a standardized format; may perform, using an enrichment system, enrichment of the first alert data, by retrieving first enrichment data from one or more second databases and adding the first enrichment data to the parsed and formatted first alert data in the first database to form first consolidated alert data; and may send the first consolidated alert data to a fault management system for display to a user to facilitate addressing of the first alert by the user.

Abstract: A configuration for an autonomous food preparation and meal production machine receives a menu order. A computer system of the machine retrieves from a database an automated recipe for fulfilment of the menu order and determines an availability of a threshold of ingredients to fulfill the menu order. The computer system transmits preparation instructions to fulfill the menu order to stations having controllers in a production line. The production line de-nests a vessel and moves it along a production line. The production line, in response to the controllers receiving the preparation instructions, automatically dispenses ingredients of the menu order into the vessel from dispensers, steams and heats the ingredients and places the vessel with the fulfilled menu order into a locker. The computer system transmits to a device a signal corresponding to the fulfillment of the menu order.

Abstract: A system and method implement biometric sensing with sensor fusion. A first sensor is coupled with a user and is capable of sensing a first characteristic of the user. A second sensor is coupled with the user and is capable of sensing a second characteristic of the user. A memory stores software with machine readable instructions that when executed by a processor implement an algorithm to correct for motion artifacts included within the second characteristic based upon activity of the user determined from the first characteristic.

Abstract: A system and a method determine an activity of a user. Sensor data is collected from a sensor within a pod worn by the user. The sensor data is matched to a signature definition corresponding to a known activity and the sensor. When the sensor data matches the signature definition, the activity of the user is determined. Sensed data, signature data, and/or matched signature data may be communicated to and from external devices. Signatures may be learned for known activities.

Abstract: Embodiments of the present invention provide a method, system and computer program product for maintaining distributed state consistency in a distributed computing application. In an embodiment of the invention, a method for maintaining distributed state consistency in a distributed computing application can include registering a set of components of a distributed computing application, starting a transaction resulting in changes of state in different ones of the components in the registered set and determining in response to a conclusion of the transaction whether or not an inconsistency of state has arisen amongst the different components in the registered set in consequence of the changes of state in the different ones of the components in the registered set. If an inconsistency has arisen, each of the components in the registered set can be directed to rollback to a previously stored state. Otherwise a committal of state can be directed in each of the components in the registered set.

Abstract: Systems, methods, and machine-readable media are disclosed for automating setup of configuration data for an application program. In one embodiment, a method of automating setup of configuration data for an application program can comprise identifying a set of configuration data used by a first instance of the application program. The set of configuration data can contain data for substantially replicating a configuration for the first instance of the application program. The method can further include extracting the set of configuration data from the first instance of the application program. A manifest can be created identifying data in the set of configuration data. The set of configuration data can be saved in a portable format that includes the set of configuration data and the manifest.

Abstract: A system and method implement biometric sensing with sensor fusion. A first sensor is coupled with a user and is capable of sensing a first characteristic of the user. A second sensor is coupled with the user and is capable of sensing a second characteristic of the user. A memory stores software with machine readable instructions that when executed by a processor implement an algorithm to correct for motion artifacts included within the second characteristic based upon activity of the user determined from the first characteristic.

Abstract: In a tampon applicator, an elongated barrel has an interior chamber for housing a tampon therein, a grip region generally adjacent an outer end of the barrel, a tip region generally adjacent an inner end of the barrel, and a central region extending longitudinally between the grip region and the tip region. A plunger extends into the barrel at the outer end thereof and is moveable relative to the barrel to expel the tampon from the barrel at its inner end. The outer surface of the barrel at the grip region has a different coefficient of friction than at the central region of the barrel. In other embodiments the coefficient of friction of the barrel outer surface at the central region is different from the coefficient of friction at the tip region.

Abstract: Embodiments of the subject matter described herein relate generally to generating multiple, multivariant prognostic data reports in aircraft. A plurality of data collection requests, one from each of a plurality of stakeholders, is received at the aircraft. A unique portion of onboard memory is associated with each of the data collection requests. Concurrently, according to the associated data collection requests, parametric data is collected and recorded as a report into each one of the unique portions of memory associated with each data collection request.

Abstract: Embodiments of the subject matter described herein relate generally to generating multiple, multivariant prognostic data reports in aircraft. A plurality of data collection requests, one from each of a plurality of stakeholders, is received at the aircraft. A unique portion of onboard memory is associated with each of the data collection requests. Concurrently, according to the associated data collection requests, parametric data is collected and recorded as a report into each one of the unique portions of memory associated with each data collection request.

Abstract: A compact, portable resistance heating device that takes a source of alternating current electricity and through a series of connections and circuitry splits the alternating current electricity into a plurality of circuits. The compact, portable resistance heating device is capable of heating a plurality of cartridge heaters at one time, individually or a combination thereof. The compact, portable resistance heating device is controlled by at least one controller that controls three (3) power output receptacles. The controller is capable of producing 0-100% output power to each respective cartridge heater. Each cartridge heater may be individually controlled by an on/off switch, and an indicator light may be provided and illuminate when each cartridge heater is energized. The cartridge heaters of the compact, portable resistance heating device do not require close tolerances with an axial bore of a stud or threaded bolt and are further capable of being bent to suit the particular operation.

Abstract: Provided are techniques for invoking with a processor executing on a computer a source code parser to obtain source information that includes a first location of an Application Programming Interface (API) call and parameters of the API call in source code of a client application, where the parameters the API call do not include query text for a query that is to be used to access a database; examining a stack trace to determine a second location of the API call in the stack trace; and deriving the query of the API call and a third location of the query in the source code by identifying the query in the stack trace at the location of the API call in the stack trace.

Abstract: Provided are techniques for collecting client information for client applications running on a client computer, wherein the client information includes a client application identifier for each client application that issues queries to a database along with text of each of the queries that the client application issues; collecting database monitoring information that includes text of each query issued against the database and performance information for each query; combining the client information and the database monitoring information based on the text of the queries to obtain combined information that provides the client application identifier and the performance information for each of the queries; and identifying a problem query and at least one client application that has issued the problem query using the combined information.

Abstract: Apparatus for maintaining at least a holding current in a leading-edge phase-cut dimmer during a period of transient voltage variations, the apparatus connectable to the dimmer and connectable to a load connected to draw current from the dimmer. The apparatus may comprise an edge detector connected to receive a voltage from the dimmer and generate a leading-edge signal in response to a leading-edge of a phase-cut waveform, and a current offset circuit connected to receive the leading-edge signal and draw a supplementary offset current in response to the leading-edge signal, wherein the supplementary offset current is sufficient to maintain at least a holding current in the dimmer during the period of transient voltage variations. The current offset circuit may comprise a holding current circuit which also draws supplementary current in response to an instantaneous value of load current.

Abstract: An illumination apparatus comprises a plurality of LEDs and a control system connected to receive dimmer-modulated AC line voltage and control the LEDs. The control system is configured to operate in a plurality of different modes wherein changes in dimmer-modulated AC line voltage adjust various characteristic of the LEDs.

Abstract: An illumination apparatus comprises a plurality of LEDs and a control system connected to receive dimmer-modulated AC line voltage and control the LEDs. The control system is configured to operate in a plurality of different modes wherein changes in dimmer-modulated AC line voltage adjust various characteristic of the LEDs.